ChemicalBook > CAS DataBase List > 3,5-Di-tert-butyl-4-methoxybenzaldehyde

3,5-Di-tert-butyl-4-methoxybenzaldehyde

Product Name
3,5-Di-tert-butyl-4-methoxybenzaldehyde
CAS No.
74684-38-1
Chemical Name
3,5-Di-tert-butyl-4-methoxybenzaldehyde
Synonyms
3,5-Di-tert-butyl-4-methoxybenzaldehyde;2-(3-(tert-butyl)-5-formylphenyl)-2-methylpropanenitrile
CBNumber
CB8144878
Molecular Formula
C16H24O2
Formula Weight
248.36
MOL File
74684-38-1.mol
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3,5-Di-tert-butyl-4-methoxybenzaldehyde Property

storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
HCH0044527
Product name
4-(2,4-DICHLOROPHENYL)BUTANOIC ACID
Purity
95.00%
Packaging
5MG
Price
$496.08
Updated
2021/12/16
Crysdot
Product number
CD12037047
Product name
3,5-Di-tert-butyl-4-methoxybenzaldehyde
Purity
97%
Packaging
5g
Price
$594
Updated
2021/12/16
Alichem
Product number
74684381
Product name
3,5-Di-tert-butyl-4-methoxybenzaldehyde
Packaging
5g
Price
$624
Updated
2021/12/16
Ambeed
Product number
A276336
Product name
3,5-Di-tert-butyl-4-methoxybenzaldehyde
Purity
97%
Packaging
25g
Price
$914
Updated
2021/12/16
Alichem
Product number
74684381
Product name
3,5-Di-tert-butyl-4-methoxybenzaldehyde
Packaging
10g
Price
$940.8
Updated
2021/12/16
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3,5-Di-tert-butyl-4-methoxybenzaldehyde Chemical Properties,Usage,Production

Synthesis

74-88-4

1620-98-0

74684-38-1

General procedure for the synthesis of 3,5-di-tert-butyl-4-hydroxybenzaldehyde from 3,5-di-tert-butyl-4-methoxybenzaldehyde and iodomethane: (1) Sodium hydride (NaH, 1.27 g, 53 mmol) was slowly added to a solution of 3,5-di-tert-butyl-4-hydroxybenzaldehyde (5 g, 21 mmol) dissolved in anhydrous tetrahydrofuran (THF, 22.5 ml) under the protection of nitrogen gas, keeping the reaction temperature at 0 °C. After the reaction mixture was removed from the cooling bath, stirring was continued for 30 minutes. (2) Subsequently, methyl iodide (CH3I, 5.2 ml, 84 mmol) dissolved in anhydrous THF (9 ml) was added to the reaction mixture and the mixture was refluxed for 12 hours. (3) After completion of the reaction, the reaction was quenched with methanol (MeOH) and then extracted with dichloromethane (CH2Cl2). (4) The organic layers were combined, concentrated and purified by column chromatography using ethyl acetate: hexane = 1:7 as eluent. (5) The final yellow liquid product 3,5-di-tert-butyl-4-methoxybenzaldehyde (4.5 g, 87% yield) was obtained. 1H NMR (CDCl3,400MHz) δ 9.91 (s, 1H), 7.79 (s, 2H), 3.73 (s, 3H), 1.46 (s, 18H).

References

[1] Patent: US9691555, 2017, B2. Location in patent: Page/Page column 29
[2] Bioorganic and Medicinal Chemistry, 2002, vol. 10, # 10, p. 3257 - 3265
[3] New Journal of Chemistry, 2006, vol. 30, # 4, p. 583 - 591

3,5-Di-tert-butyl-4-methoxybenzaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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3,5-Di-tert-butyl-4-methoxybenzaldehyde Suppliers

China 13 Europe 2 Germany 1 India 2 South Korea 1 United Kingdom 1 United States 1 Global 21
Bide Pharmatech Ltd.
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400-164-7117 13681763483
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product02@bidepharm.com
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China
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Aikon International Limited
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025-58859352 18068836627
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sales01@aikonchem.com
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China
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Blocksynth Pharmaceutical Technology Co.,Ltd
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Shanghai Subo Pharmaceutical Technology Co., Ltd.
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Qingfeng Chem
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Energy Chemical
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Bide Pharmatech Ltd.
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Henan Alpha Chemical Co., Ltd.
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Beijing Solarbio Science & Tecnology Co., Ltd.
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Zhuhai Aobokai Biomedical Technology Co., Ltd.
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74684-38-1, 3,5-Di-tert-butyl-4-methoxybenzaldehydeRelated Search:

FMOC-(R)-3-AMINO-4-(2,4-DICHLORO-PHENYL)-BUTYRIC ACID BOC-(S)-3-AMINO-4-(2,4-DICHLORO-PHENYL)-BUTYRIC ACID FMOC-(S)-3-AMINO-4-(2,4-DICHLORO-PHENYL)-BUTYRIC ACID BOC-(R)-3-AMINO-4-(2,4-DICHLORO-PHENYL)-BUTYRIC ACID (S)-3-AMINO-4-(2,4-DICHLOROPHENYL)BUTANOIC ACID HYDROCHLORIDE L-689,560 4-(2,4-DICHLORO-PHENYL)-2,4-DIOXO-BUTYRIC ACID METHYL ESTER 4-(2,4-DICHLORO-PHENYL)-2,4-DIOXO-BUTYRIC ACID (R)-3-AMINO-4-(2,4-DICHLOROPHENYL)BUTANOIC ACID HYDROCHLORIDE 3,5-Di-tert-butyl-4-methoxybenzaldehyde 4-(2,4-DICHLORO-PHENYL)-3-OXO-BUTYRIC ACID ETHYL ESTER 5-(2,4-DICHLORO-PHENYL)-4H-PYRAZOLE-3-CARBOXYLIC ACID 4-(2,4-DICHLOROPHENYL)-4-OXOBUTYRIC ACID ethyl 4-(2,4-dichlorophenyl)-2,4-dioxobutanoate (3AR,4S,9BS)-7,9-DICHLORO-3A,4,5,9B-TETRAHYDRO-3H-CYCLOPENTA[C]QUINOLINE-4-CARBOXYLIC ACID Benzenebutanoic acid, 2,4-dichloro-alpha-hydroxy-gamma-oxo- ETHYL 4-(2,4-DICHLOROPHENYL)-4-OXOBUTYRATE 2-AMINO-4-(2,4-DICHLORO-PHENYL)-BUTYRIC ACID

  • 3,5-Di-tert-butyl-4-methoxybenzaldehyde
  • 2-(3-(tert-butyl)-5-formylphenyl)-2-methylpropanenitrile
  • 74684-38-1