3-Methyl-1,2,3,4-tetrahydroquinoline
- Product Name
- 3-Methyl-1,2,3,4-tetrahydroquinoline
- CAS No.
- 20668-20-6
- Chemical Name
- 3-Methyl-1,2,3,4-tetrahydroquinoline
- Synonyms
- Argatroban impurity C;Argatroban Impurity 67;Quinoline, 1,2,3,4-tetrahydro-3-me;3-Methyl-1,2,3,4-tetrahydroquinoline;1,2,3,4-Tetrahydro-3-methylquinoline;Quinoline, 1,2,3,4-tetrahydro-3-methyl-
- CBNumber
- CB81449769
- Molecular Formula
- C10H13N
- Formula Weight
- 147.22
- MOL File
- 20668-20-6.mol
3-Methyl-1,2,3,4-tetrahydroquinoline Property
- Boiling point:
- 117 °C(Press: 15 Torr)
- Density
- 0.9931 g/cm3
- storage temp.
- 2-8°C(protect from light)
- pka
- 5.13±0.40(Predicted)
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M341155
- Product name
- 3-Methyl-1,2,3,4-tetrahydroquinoline
- Packaging
- 250mg
- Price
- $330
- Updated
- 2021/12/16
- Product number
- 6803CC
- Product name
- 3-Methyl-1,2,3,4-tetrahydroquinoline
- Packaging
- 250mg
- Price
- $301
- Updated
- 2021/12/16
- Product number
- CD11167927
- Product name
- 3-Methyl-1,2,3,4-tetrahydroquinoline
- Purity
- 98%
- Packaging
- 1g
- Price
- $292
- Updated
- 2021/12/16
- Product number
- CM128017
- Product name
- 3-methyl-1,2,3,4-tetrahydroquinoline
- Purity
- 98%
- Packaging
- 1g
- Price
- $337
- Updated
- 2021/12/16
- Product number
- 20668206
- Product name
- 3-Methyl-1,2,3,4-tetrahydroquinoline
- Packaging
- 1g
- Price
- $370.8
- Updated
- 2021/12/16
3-Methyl-1,2,3,4-tetrahydroquinoline Chemical Properties,Usage,Production
Synthesis Reference(s)
Chemical and Pharmaceutical Bulletin, 32, p. 2421, 1984 DOI: 10.1248/cpb.32.2421
Synthesis
612-58-8
20668-20-6
GENERAL STEPS: PdNPore catalyst (1.1 mg, 2 mol%) was dissolved in acetonitrile (5 mL), followed by the addition of 3-methylquinoline (7.6 mg, 0.5 mmol). The reaction system was placed on a magnetic stirrer at 50 °C for 24 h under hydrogen (5 bar) atmosphere. Upon completion of the reaction, it was purified by column chromatography (silica gel, 200-300 mesh, ethyl acetate as eluent) to afford the target product 3-methyl-1,2,3,4-tetrahydroquinoline (61.1 mg) in 83% yield.
References
[1] Journal of the American Chemical Society, 2011, vol. 133, # 25, p. 9878 - 9891
[2] Advanced Synthesis and Catalysis, 2017, vol. 359, # 6, p. 933 - 940
[3] Chemical Communications, 2013, vol. 49, # 63, p. 7052 - 7054
[4] Advanced Synthesis and Catalysis, 2015, vol. 357, # 16-17, p. 3529 - 3537
[5] Organic Letters, 2013, vol. 15, # 7, p. 1484 - 1487
3-Methyl-1,2,3,4-tetrahydroquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
3-Methyl-1,2,3,4-tetrahydroquinoline Suppliers
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