ChemicalBook > CAS DataBase List > (1-BOC-piperidin-4-yl)acetonitrile

(1-BOC-piperidin-4-yl)acetonitrile

Product Name: (1-BOC-piperidin-4-yl)acetonitrile
CAS No.: 256411-39-9
Chemical Name: (1-BOC-piperidin-4-yl)acetonitrile
Synonyms: 1-Boc-3-CyanoMethylpiperidine;1-BOC-4-cyanomethylpiperidine;N-Boc-piperidine-4-acetonitrile;(1-BOC-piperidin-4-yl)acetonitrile;tert-Butyl 4-(cyanomethyl)piperidin-1-carboxylate;Tert-Butyl 4-(cyanomethyl)piperidine-1-carboxylate;4-CyanoMethyl-piperidine-1-carboxylicacidtert-butylester;1-Piperidinecarboxylic acid, 4-(cyanomethyl)-, 1,1-dimethylethyl ester
CBNumber: CB81457218
Molecular Formula: C12H20N2O2
Formula Weight: 224.3
MOL File: 256411-39-9.mol

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(1-BOC-piperidin-4-yl)acetonitrile Property

Boiling point:: 344.3±15.0 °C(Predicted)
Density: 1.040±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: -1.91±0.40(Predicted)
Appearance: White to light yellow Solid

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Safety

HazardClass: IRRITANT
HS Code: 2916399090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: T135600
Product name: tert-Butyl4-(Cyanomethyl)piperidine-1-carboxylate
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB139761
Product name: tert-Butyl 4-(cyanomethyl)piperidine-1-carboxylate
Packaging: 1g
Price: $77
Updated: 2021/12/16

AK Scientific

Product number: J94775
Product name: 1-Boc-4-(Cyanomethyl)piperidine
Packaging: 5g
Price: $85
Updated: 2021/12/16

AK Scientific

Product number: W4894
Product name: 1-Boc-4-(Cyanomethyl)piperidine
Packaging: 1g
Price: $41
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB139761
Product name: tert-Butyl 4-(cyanomethyl)piperidine-1-carboxylate
Packaging: 2g
Price: $134
Updated: 2021/12/16

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(1-BOC-piperidin-4-yl)acetonitrile Chemical Properties,Usage,Production

Synthesis

773837-37-9

123855-51-6

256411-39-9

The reaction was carried out with tert-butyl 4-((methylsulfonyl)oxymethyl)piperidine-1-carboxylate (15.3 g) and NaCN (4.00 g, 80.0 mmol) in a mixed solvent of EtOH (80 ml) and H2O (20 ml) with stirring for 24 hours at 80°C. After completion of the reaction, the solvent was removed by vacuum concentration. The residue was dissolved in AcOEt (300 ml) and H2O (100 ml) and the aqueous layer was extracted with AcOEt (300 ml). The organic layers were combined, washed with brine (100 ml), dried over Na2SO4, filtered and concentrated in vacuum. The residue was purified by silica gel column chromatography (eluent: hexane-AcOEt) to afford the target product 1-Boc-4-(cyanomethyl)piperidine (6.87 g, 76.6% yield) as a white solid.1H NMR (400 MHz, CDCl3) δ 1.21-1.31 (2H, m), 1.46 (9H, s), 1.78-1.86 (3H m), 2.31 (2H, d, J=6.4Hz), 2.64-2.78 (2H, m), 4.07-4.21 (2H, m).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 15, p. 3249 - 3253

(1-BOC-piperidin-4-yl)acetonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (1-BOC-piperidin-4-yl)acetonitrile manufacturers

Career Henan Chemical Co

Product: (1-BOC-piperidin-4-yl)acetonitrile 256411-39-9
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-08

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