(4-propan-2-yloxyphenyl)methanol
- Product Name
- (4-propan-2-yloxyphenyl)methanol
- CAS No.
- 82657-71-4
- Chemical Name
- (4-propan-2-yloxyphenyl)methanol
- Synonyms
- (4-isopropoxyphenyl)methanol;(4-propan-2-yloxyphenyl)methanol;4-(1-Methylethoxy)-benzenemethanol;Benzenemethanol, 4-(1-methylethoxy)-
- CBNumber
- CB81458457
- Molecular Formula
- C10H14O2
- Formula Weight
- 166.22
- MOL File
- 82657-71-4.mol
(4-propan-2-yloxyphenyl)methanol Property
- Melting point:
- 27-28 °C
- Boiling point:
- 144-146 °C(Press: 12 Torr)
- Density
- 1.034±0.06 g/cm3(Predicted)
- storage temp.
- Store at room temperature
- pka
- 14.68±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
Safety
- HS Code
- 2909498090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- I918325
- Product name
- 4-IsopropoxybenzylAlcohol
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 303185
- Product name
- 4-Isopropoxybenzylalcohol
- Purity
- 97%
- Packaging
- 1g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- 1352AL
- Product name
- [4-(Propan-2-yloxy)phenyl]methanol
- Packaging
- 1g
- Price
- $157
- Updated
- 2021/12/16
- Product number
- CHM0103781
- Product name
- [4-(PROPAN-2-YLOXY)PHENYL]METHANOL
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $765.23
- Updated
- 2021/12/16
- Product number
- CHM0103781
- Product name
- [4-(PROPAN-2-YLOXY)PHENYL]METHANOL
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $1065.66
- Updated
- 2021/12/16
(4-propan-2-yloxyphenyl)methanol Chemical Properties,Usage,Production
Synthesis Reference(s)
Journal of Medicinal Chemistry, 32, p. 1757, 1989 DOI: 10.1021/jm00128a016
Synthesis
18962-05-5
82657-71-4
To a methanolic solution of 4-isopropoxybenzaldehyde (0.93 g, 5.6 mmol) in methanol (20 mL) was slowly added a methanolic solution of sodium tetrahydroborate (0.32 g, 11 mmol) under cooling conditions in an ice bath. The reaction mixture was stirred at room temperature for 4 hours. Upon completion of the reaction, the reaction solution was acidified by adding 2N hydrochloric acid to the reaction solution and subsequently extracted with ether. The organic phases were combined, washed with water and concentrated under reduced pressure to remove the solvent. The residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate = 7:3) to afford the target product (4-isopropoxyphenyl) methanol (0.76 g, 81% yield) as a colorless oil.1H NMR (CDCl3) δ: 1.33 (6H, d, J = 6.1 Hz), 4.55 (1H, quintet, J = 6.1 Hz), 4.61 (2H, s), 6.85-6.91 (2H, m), 7.25-7.30 (2H, m).
References
[1] Tetrahedron Letters, 2015, vol. 56, # 46, p. 6460 - 6462
[2] ChemMedChem, 2016, vol. 11, # 13, p. 1415 - 1427
[3] Patent: EP1688138, 2006, A1. Location in patent: Page/Page column 106
[4] Tetrahedron, 2013, vol. 69, # 2, p. 933 - 941
(4-propan-2-yloxyphenyl)methanol Preparation Products And Raw materials
Raw materials
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View Lastest Price from (4-propan-2-yloxyphenyl)methanol manufacturers
- Product
- (4-(propan-2-yloxy)phenyl)methanol 82657-71-4
- Price
- US $0.00/kg
- Min. Order
- 20kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2025-04-21