ChemicalBook > CAS DataBase List > L-A-HYDROXYGLUTARIC ACID DISODIUM)

L-A-HYDROXYGLUTARIC ACID DISODIUM)

Product Name: L-A-HYDROXYGLUTARIC ACID DISODIUM)
CAS No.: 63512-50-5
Chemical Name: L-A-HYDROXYGLUTARIC ACID DISODIUM)
Synonyms: L-2-HG;SKL187;disodium L-2-hydroxyglutarate;Disodium (S)-2-hydroxyglutarate;(S)-2-Hydroxypentanedioic acid;Sodium (S)-2-hydroxypentanedioate;L-2-Hydroxyglutarate DisodiuM Salt;L-α-Hydroxyglutaricaciddisodiumsal;L-2-Hydroxyglutaric acid (disodium);(S)-2-Hydroxyglutaric acid disodium
CBNumber: CB81473690
Molecular Formula: C5H9NaO5
Formula Weight: 172.11
MOL File: 63512-50-5.mol

Less

L-A-HYDROXYGLUTARIC ACID DISODIUM) Property

Melting point:: >300°C
storage temp.: 2-8°C
solubility: Methanol (Very Slightly), Water (Slightly)
form: Solid
color: White to Off-White
optical activity: [α]/D -8.5±1.5°, c = 1 in 0.1 M NaOH
BRN: 5318042

Less

Safety

WGK Germany: 3

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 90790
Product name: L-α-Hydroxyglutaric acid disodium salt
Purity: ≥98.0% (GC)
Packaging: 10mg
Price: $96.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: 90790
Product name: L-α-Hydroxyglutaric acid disodium salt
Purity: ≥98.0% (GC)
Packaging: 50mg
Price: $337
Updated: 2025/07/31

Cayman Chemical

Product number: 11876
Product name: L-α-Hydroxyglutaric Acid (sodium salt)
Purity: ≥95%
Packaging: 5mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 11876
Product name: L-α-Hydroxyglutaric Acid (sodium salt)
Purity: ≥95%
Packaging: 10mg
Price: $61
Updated: 2024/03/01

Cayman Chemical

Product number: 11876
Product name: L-α-Hydroxyglutaric Acid (sodium salt)
Purity: ≥95%
Packaging: 25mg
Price: $131
Updated: 2024/03/01

Less

L-A-HYDROXYGLUTARIC ACID DISODIUM) Chemical Properties,Usage,Production

Description

L-α-Hydroxyglutaric acid (L-2-HG) is an α-hydroxy acid. It is metabolized to 2-oxoglutarate (α-ketoglutarate) by L-2-hydroxyglutarate dehydrogenase, and mutations in this enzyme lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased L-2-HG levels. L-2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including several involved in histone lysine and DNA demethylation.

Chemical Properties

White Solid

Uses

L-α-Hydroxyglutaric acid disodium salt is suitable for use in collection buffer for increased recovery of hypoxia-inducible factor-1 α (HIF-1α), a marker of hypoxia in human tumors. It is also suitable for the radiolabeled 5mC-5hmC conversion assay to study the effect of 2-HG on the TET family of methyl hydroxylases.

Uses

A potential inhibitor of glutamate carboxypeptidase.

General Description

Glutamic acid is metabolized to α-Hydroxyglutaric acid in an NAD-dependent manner by cell-free extracts of Peptococcus aerogenes. It is formed as an intermediate during glyoxylic acid metabolism in bacteria.

Biochem/physiol Actions

L-alpha-Hydroxyglutaric acid accumulates as a result of a rare defect in L-2-HG dehydogenase, leading to the metabolic disorder L-2-hydroxyglutaric aciduria (L-2HGA). L-2HGA is associated with neuronal defects, leukodystrophy and linked to an increased risk of brain tumors.

in vitro

it has been reported that l-α-hydroxyglutaric acid disodium salt could be used as the collection buffer for increasing the recovery of hypoxia-inducible factor-1 α, which was a marker of hypoxia in human tumors [1]. in another previous study, l-α-hydroxyglutaric acid disodium salt was also used in the radiolabeled conversion assay to evaluate its effect on the tet family of methyl hydroxylases [2].

in vivo

in the 30-day-old rats, l-α-hydroxyglutaric acid was found to be able to significantly increase chemiluminescence, pcf and tba-rs measurements and decrease the tar values in cerebellum markedly. in addition, the l-α-hydroxyglutaric acid-induced increase of tba-rs was significantly attenuated by melatonin and also by the combinations of ascorbic acid and soluble alpha-tocopherol (trolox) and of superoxide dismutase plus catalase but not by the inhibitor of nitric oxide synthase nomega-nitro-l-arginine methyl ester (l-name), , superoxide dismutase or creatine or catalase alone in either cerebral structure [3].

References

[1] park sr,kinders rj,khin s,et al. validation of a hypoxia-inducible factor-1 alpha specimen collection procedure and quantitative enzyme-linked immunosorbent assay in solid tumor tissues. anal biochem.2014 aug 15;459:1-11.
[2] evans b,griner e. registered report: oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. elife.2015 jul 31;4:e07420.
[3] latini a,scussiato k,rosa rb,leipnitz g,llesuy s,belló-klein a,dutra-filho cs,wajner m. induction of oxidative stress by l-2-hydroxyglutaric acid in rat brain. j neurosci res.2003 oct 1;74(1):103-10.

L-A-HYDROXYGLUTARIC ACID DISODIUM) Preparation Products And Raw materials

Raw materials

Preparation Products

Less

L-A-HYDROXYGLUTARIC ACID DISODIUM) Suppliers

Canada 1 CHINA 105 India 1 Switzerland 1 United States 7 Global 115

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18729
Advantage: 57

Dtchem Laboratories,（Gan Su）Co.,Ltd.

Tel: 18993966060
Fax: 0943-8288977
Email: sales@techbiochem.com
Country: China
ProdList: 806
Advantage: 61

Shanghai Topbiochem Technology Co., Ltd

Tel: +86-21-60341587
Fax: +86-21-61294319
Email: sales@topbiochem.com
Country: China
ProdList: 6175
Advantage: 58

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10263
Advantage: 55

Shanghai Xingui Biotechnology Co., Ltd.

Tel: 15121041756
Email: xingui2022@126.com
Country: China
ProdList: 9979
Advantage: 58

Chizhou Kailong Import and Export Trade Co., Ltd.

Tel
Fax: -
Email: xg01_gj@163.com
Country: China
ProdList: 9484
Advantage: 50

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Chengdu Chuangkecheng Biological Technology Co., Ltd.

Tel: 028-028-0000000 13008177686
Fax: 15928581901
Email: sales@ckcbiotech.com
Country: China
ProdList: 904
Advantage: 55

Struchem Co., Ltd.

Tel: 0512-63009836 18994340901
Fax: 0512-63006936
Email: helen@struchem.com
Country: China
ProdList: 3981
Advantage: 60

Zhengzhou Alfachem Co., Ltd.

Tel: 0371-53765687 18937137882
Fax: QQ:2885373884
Email: 2853979813@qq.com
Country: China
ProdList: 7992
Advantage: 55

Shanghai Haozhixiang Biotechnology Co., Ltd

Tel: 526763801 13301653310
Fax: +86-21-51619052
Email: 526763801@qq.com
Country: China
ProdList: 9274
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Chengdu Huachun Technology Co., Ltd

Tel: 400-1166-196 15982826727
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14603
Advantage: 60

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Beyond Pharmaceutical Co., Ltd

Tel: 0571-81953185 +86-15381198709
Fax: 0571-89086206
Email: jasonyao@bydpharma.com
Country: China
ProdList: 842
Advantage: 60

Shanghai Zhen Li Biological Technology Co., Ltd

Tel: 021-16621358918; 18516310516
Fax: 13045646768
Email: zhenlipharma888@163.com
Country: China
ProdList: 19035
Advantage: 58

Aikon International Limited

Tel: 025-66061636 18013972705
Fax: (3)02557626880
Email: qqyang@aikonchem.com
Country: China
ProdList: 15814
Advantage: 58

SHANGHAI FDC-CHEMICAL CO.,LTD

Tel: 021-61469567 13482353728
Fax: 021-61161605
Email: sales@fdc-chemical.com
Country: China
ProdList: 9713
Advantage: 58

Beijing OKA biological technology co., LTD

Tel: 010-62971590 18548936886
Fax: 010-62340519
Email: 3462612863@qq.com
Country: China
ProdList: 10063
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418671 +8618949823763
Fax: 0551-65418697
Email: sales@tnjchem.com
Country: China
ProdList: 34563
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52846
Advantage: 58

Taizhou Changyuan Chemical Technology Co., Ltd.

Tel: 15005869072
Email: tzcyhxkj@163.com
Country: China
ProdList: 507
Advantage: 58

Shanghai Kaiwei Chemical Technology Co., Ltd.

Tel: 021-58461859 15821823057
Email: service@aiviche.com
Country: China
ProdList: 49312
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29798
Advantage: 58

Guangzhou Younan Technology Co., Ltd

Tel: 020-82000279 18988941452
Fax: QQ：3283937693
Email: YN_research@163.com
Country: China
ProdList: 3011
Advantage: 58

ShangHai Anpel Co, Ltd.

Tel: 18501792038 18502138905
Email: shanpel@anpel.com.cn
Country: China
ProdList: 9611
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-025-85560043 17301488900
Fax: 025-85563444
Email: info@synzest.com
Country: China
ProdList: 9286
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Hubei yongkuo Technology Co., Ltd

Tel: 027-027-59223108 15972152991
Fax: 027-59223108
Email: 1248580099@qq.com
Country: China
ProdList: 10005
Advantage: 58

Hubei Xinkang Pharmaceutical Chemical Co., Ltd

Tel: 027-027-59308705 18871579363
Fax: 027-59308705
Email: 1248680011@qq.com
Country: China
ProdList: 9850
Advantage: 58

Hubei Shishun Biotechnology Co. Ltd

Tel: 027-027-59223025 15107168801
Fax: 027-59223025
Email: 1718480011@qq.com
Country: China
ProdList: 9758
Advantage: 58

Hubei Baidu Chemical Co., Ltd

Tel: 027-027-59106051 13627137652
Fax: 027-59223020
Email: 1438180055@qq.com
Country: China
ProdList: 8779
Advantage: 58

Hubei Guangao Biotechnology Co., Ltd

Tel: 027-02702759223056 18162699093
Fax: 027-59223056
Email: 1208480011@qq.com
Country: China
ProdList: 9875
Advantage: 58

Hubei Wande Chemical Co., Ltd

Tel: 027-027-59210159 15377098680
Fax: 027-59210159
Email: 1148280011@qq.com
Country: China
ProdList: 9835
Advantage: 58

Tianmen Hengchang Chemical Co., Ltd

Tel: 027-027-59322316 15172518801
Fax: 027-59322316
Email: 1208480077@qq.com
Country: China
ProdList: 9850
Advantage: 58

Hubei Qifei Pharmaceutical Chemical Co., Ltd

Tel: 027-59322506 18071128681
Fax: 027-59322506
Email: 1438082200@qq.com
Country: China
ProdList: 9921
Advantage: 58

Hubei xingongli Chemical Co., Ltd

Tel: 027-027-59106151 15172325309
Fax: 027-59503710
Email: 1400858877@qq.com
Country: China
ProdList: 9928
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 18351873721
Email: helen.zhang@synzest.com
Country: China
ProdList: 8295
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Shanghai Maclean Biochemical Technology Co., LTD

Tel: 021-021-50706066 15221275939
Email: shenlinxing@macklin.cn
Country: China
ProdList: 29784
Advantage: 58

Less

View Lastest Price from L-A-HYDROXYGLUTARIC ACID DISODIUM) manufacturers

Career Henan Chemical Co

Product: L-A-HYDROXYGLUTARIC ACID DISODIUM) 63512-50-5
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-13

63512-50-5, L-A-HYDROXYGLUTARIC ACID DISODIUM)Related Search:

Angeli’s Salt Lignosulfonic acid 2-hydroxyglutaric acid

(S)-2-Hydroxypentanedioic acid

L-α-Hydroxyglutaric acid disodium salt

(2S)-2-Hydroxyglutaric Acid Disodium Salt

Pentanedioic acid,2-hydroxy-, disodium salt, (2S)-

s-2-Hydroxypentanedioic acid disodium salt

L-2-Hydroxyglutaric acid (disodium)

L-α-Hydroxyglutaric Acid (sodium salt)

Pentanedioic acid, 2-hydroxy-, sodiuM salt (1:2)

Disodium (S)-2-hydroxyglutarate

L-ALPHA-HYDROXYGLUTARIC ACID DISODIU

(S)-α-Hydroxyglutaric Acid DisodiuM Salt

L-2-Hydroxyglutarate DisodiuM Salt

L-alpha-hydroxyglutaric acid, disodium salt

Sodium (S)-2-hydroxypentanedioate

L-a-Hydroxyglutaric acid disodium salt

L-2-HG

(S)-2-Hydroxyglutaric acid disodium

Pentanedioic acid, 2-?hydroxy-?, sodium salt (1:2)?, (2S)?-

L-α-Hydroxyglutaric acid disodium salt

SKL187

L-α-Hydroxyglutaricaciddisodiumsal

L 2 Hydroxyglutaric acid disodium,modifier,demethylases,methylation,Mitochondrial Metabolism,Histone Demethylase,Inhibitor,renal,cancer,epigenetic,inhibit,histone,L2Hydroxyglutaric acid disodium

disodium L-2-hydroxyglutarate

<sc>L-</sc>α-Hydroxyglutaric acid disodium salt

L-alpha-Hydroxyglutaric acid disodium salt[90790]

63512-50-5

C5H6O5Na2

C5H8Na2O5

Inhibitors

Aliphatics

Chiral Reagents