L-A-HYDROXYGLUTARIC ACID DISODIUM)
- Product Name
- L-A-HYDROXYGLUTARIC ACID DISODIUM)
- CAS No.
- 63512-50-5
- Chemical Name
- L-A-HYDROXYGLUTARIC ACID DISODIUM)
- Synonyms
- L-2-HG;SKL187;disodium L-2-hydroxyglutarate;Disodium (S)-2-hydroxyglutarate;(S)-2-Hydroxypentanedioic acid;Sodium (S)-2-hydroxypentanedioate;L-2-Hydroxyglutarate DisodiuM Salt;L-α-Hydroxyglutaricaciddisodiumsal;L-2-Hydroxyglutaric acid (disodium);(S)-2-Hydroxyglutaric acid disodium
- CBNumber
- CB81473690
- Molecular Formula
- C5H9NaO5
- Formula Weight
- 172.11
- MOL File
- 63512-50-5.mol
L-A-HYDROXYGLUTARIC ACID DISODIUM) Property
- Melting point:
- >300°C
- storage temp.
- 2-8°C
- solubility
- Methanol (Very Slightly), Water (Slightly)
- form
- Solid
- color
- White to Off-White
- optical activity
- [α]/D -8.5±1.5°, c = 1 in 0.1 M NaOH
- BRN
- 5318042
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- 90790
- Product name
- L-α-Hydroxyglutaric acid disodium salt
- Purity
- ≥98.0% (GC)
- Packaging
- 10mg
- Price
- $94.1
- Updated
- 2024/03/01
- Product number
- 90790
- Product name
- L-α-Hydroxyglutaric acid disodium salt
- Purity
- ≥98.0% (GC)
- Packaging
- 50mg
- Price
- $328
- Updated
- 2024/03/01
- Product number
- 11876
- Product name
- L-α-Hydroxyglutaric Acid (sodium salt)
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 11876
- Product name
- L-α-Hydroxyglutaric Acid (sodium salt)
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $61
- Updated
- 2024/03/01
- Product number
- 11876
- Product name
- L-α-Hydroxyglutaric Acid (sodium salt)
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $131
- Updated
- 2024/03/01
L-A-HYDROXYGLUTARIC ACID DISODIUM) Chemical Properties,Usage,Production
Description
L-α-Hydroxyglutaric acid (L-2-HG) is an α-hydroxy acid. It is metabolized to 2-oxoglutarate (α-ketoglutarate) by L-2-hydroxyglutarate dehydrogenase, and mutations in this enzyme lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased L-2-HG levels. L-2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including several involved in histone lysine and DNA demethylation.
Chemical Properties
White Solid
Uses
L-α-Hydroxyglutaric acid disodium salt is suitable for use in collection buffer for increased recovery of hypoxia-inducible factor-1 α (HIF-1α), a marker of hypoxia in human tumors. It is also suitable for the radiolabeled 5mC-5hmC conversion assay to study the effect of 2-HG on the TET family of methyl hydroxylases.
Uses
A potential inhibitor of glutamate carboxypeptidase.
General Description
Glutamic acid is metabolized to α-Hydroxyglutaric acid in an NAD-dependent manner by cell-free extracts of Peptococcus aerogenes. It is formed as an intermediate during glyoxylic acid metabolism in bacteria.
Biochem/physiol Actions
L-alpha-Hydroxyglutaric acid accumulates as a result of a rare defect in L-2-HG dehydogenase, leading to the metabolic disorder L-2-hydroxyglutaric aciduria (L-2HGA). L-2HGA is associated with neuronal defects, leukodystrophy and linked to an increased risk of brain tumors.
in vitro
it has been reported that l-α-hydroxyglutaric acid disodium salt could be used as the collection buffer for increasing the recovery of hypoxia-inducible factor-1 α, which was a marker of hypoxia in human tumors [1]. in another previous study, l-α-hydroxyglutaric acid disodium salt was also used in the radiolabeled conversion assay to evaluate its effect on the tet family of methyl hydroxylases [2].
in vivo
in the 30-day-old rats, l-α-hydroxyglutaric acid was found to be able to significantly increase chemiluminescence, pcf and tba-rs measurements and decrease the tar values in cerebellum markedly. in addition, the l-α-hydroxyglutaric acid-induced increase of tba-rs was significantly attenuated by melatonin and also by the combinations of ascorbic acid and soluble alpha-tocopherol (trolox) and of superoxide dismutase plus catalase but not by the inhibitor of nitric oxide synthase nomega-nitro-l-arginine methyl ester (l-name), , superoxide dismutase or creatine or catalase alone in either cerebral structure [3].
References
[1] park sr,kinders rj,khin s,et al. validation of a hypoxia-inducible factor-1 alpha specimen collection procedure and quantitative enzyme-linked immunosorbent assay in solid tumor tissues. anal biochem.2014 aug 15;459:1-11.
[2] evans b,griner e. registered report: oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. elife.2015 jul 31;4:e07420.
[3] latini a,scussiato k,rosa rb,leipnitz g,llesuy s,belló-klein a,dutra-filho cs,wajner m. induction of oxidative stress by l-2-hydroxyglutaric acid in rat brain. j neurosci res.2003 oct 1;74(1):103-10.
L-A-HYDROXYGLUTARIC ACID DISODIUM) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from L-A-HYDROXYGLUTARIC ACID DISODIUM) manufacturers
- Product
- L-A-HYDROXYGLUTARIC ACID DISODIUM) 63512-50-5
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-13