2-BROMO-5-PHENYL-1,3,4-OXADIAZOLE
- Product Name
- 2-BROMO-5-PHENYL-1,3,4-OXADIAZOLE
- CAS No.
- 51039-53-3
- Chemical Name
- 2-BROMO-5-PHENYL-1,3,4-OXADIAZOLE
- Synonyms
- 1,3,4-Oxadiazole,2-bromo-5-phenyl-
- CBNumber
- CB81490574
- Molecular Formula
- C8H5BrN2O
- Formula Weight
- 225.04
- MOL File
- 51039-53-3.mol
2-BROMO-5-PHENYL-1,3,4-OXADIAZOLE Property
- Melting point:
- 107-109 °C
- Boiling point:
- 318.8±25.0 °C(Predicted)
- Density
- 1.605±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- pka
- -7.32±0.32(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B292635
- Product name
- 2-bromo-5-phenyl-1,3,4-oxadiazole
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FB154232
- Product name
- 2-Bromo-5-phenyl-1,3,4-oxadiazole
- Packaging
- 250mg
- Price
- $112.5
- Updated
- 2021/12/16
- Product number
- FB154232
- Product name
- 2-Bromo-5-phenyl-1,3,4-oxadiazole
- Packaging
- 100mg
- Price
- $57
- Updated
- 2021/12/16
- Product number
- HCH0018793
- Product name
- 2-BROMO-5-PHENYL-1,3,4-OXADIAZOLE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $983.52
- Updated
- 2021/12/16
- Product number
- W6614
- Product name
- 2-Bromo-5-phenyl-1,3,4-oxadiazole
- Packaging
- 10g
- Price
- $1277
- Updated
- 2021/12/16
2-BROMO-5-PHENYL-1,3,4-OXADIAZOLE Chemical Properties,Usage,Production
Synthesis
825-56-9
51039-53-3
General procedure for the synthesis of 2-bromo-5-phenyl-1,3,4-oxadiazole from 2-phenyl-1,3,4-oxadiazole: To a 500 mL four-necked flask was added tetrahydrofuran (170 mL) and 2-phenyl-1,3,4-oxadiazole (17.0 g, 0.1163 mol). The reaction mixture was cooled to -65 to -70 °C under nitrogen protection and n-butyllithium (60.66 mL, 2.3 M in hexane, 0.1395 mol) was added dropwise over a period of 1 h. The reaction was stirred for 1.0 h at the same temperature. Subsequently, bromine (11.15 g, 0.1395 mol) was added slowly at -65 to -70 °C. The reaction was continued to be stirred at the same temperature for 1.0 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the mixture was slowly warmed to -10 °C and the reaction was quenched with 1.0 N HCl solution (100 mL). The mixture was further warmed to room temperature and extracted with ethyl acetate (2 x 100 mL). The organic layers were combined, washed sequentially with water (100 mL) and brine (100 mL), dried over anhydrous sodium sulfate, and concentrated to a volume under reduced pressure. Crystallization by petroleum ether gave 2-bromo-5-phenyl-1,3,4-oxadiazole as a white solid (yield: 24.3 g, 93%). 1H-NMR (400 MHz, DMSO-d6): δ 7.57-7.68 (m, 3H), 7.95-7.98 (m, 2H). MS (ESI) m/z: 226.0.
References
[1] Letters in Drug Design and Discovery, 2013, vol. 10, # 8, p. 783 - 791
2-BROMO-5-PHENYL-1,3,4-OXADIAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-BROMO-5-PHENYL-1,3,4-OXADIAZOLE manufacturers
- Product
- 2-BROMO-5-PHENYL-1,3,4-OXADIAZOLE 51039-53-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-17