4-CHLORO-7-BROMOINDOLE

Product Name: 4-CHLORO-7-BROMOINDOLE
CAS No.: 126811-29-8
Chemical Name: 4-CHLORO-7-BROMOINDOLE
Synonyms: 4-CHLORO-7-BROMOINDOLE;7-Bromo-4-chloroindole;1H-Indole, 7-broMo-4-chloro-
CBNumber: CB81508097
Molecular Formula: C8H5BrClN
Formula Weight: 230.49
MOL File: 126811-29-8.mol

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4-CHLORO-7-BROMOINDOLE Property

Boiling point:: 345.8±22.0 °C(Predicted)
Density: 1.772±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 14.43±0.30(Predicted)
Appearance: Off-white to pink Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B702808
Product name: 7-Bromo-4-chloro-1H-indole
Packaging: 10mg
Price: $75
Updated: 2021/12/16

Matrix Scientific

Product number: 098834
Product name: 7-Bromo-4-chloro-1H-indole
Purity: 95+%
Packaging: 250mg
Price: $288
Updated: 2021/12/16

AK Scientific

Product number: 5275AA
Product name: 7-Bromo-4-chloro-1H-indole
Packaging: 1g
Price: $371
Updated: 2021/12/16

Matrix Scientific

Product number: 098834
Product name: 7-Bromo-4-chloro-1H-indole
Purity: 95+%
Packaging: 1g
Price: $639
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0043877
Product name: 7-BROMO-4-CHLORO-1H-INDOLE
Purity: 95.00%
Packaging: 1G
Price: $981.75
Updated: 2021/12/16

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4-CHLORO-7-BROMOINDOLE Chemical Properties,Usage,Production

Uses

4-Chloro-7-bromoindole is an indole derivative and can be used in pharmaceutical synthesis and experimental research.

Synthesis

41513-04-6

1826-67-1

126811-29-8

General procedure for the synthesis of 4-chloro-7-bromoindole from 2-bromo-5-chloronitrobenzene and vinylmagnesium bromide: 1.19 g (5 mmol) of 2-bromo-5-chloronitrobenzene was dissolved in 50 mL of anhydrous THF. Under the protection of nitrogen, 15 mL of 1 M vinylmagnesium bromide in THF solution was added slowly dropwise at -45 °C, and the reaction temperature was controlled not to exceed -40 °C. The reaction was carried out at -40 °C. After the dropwise addition was completed, the resulting dark-colored reaction solution was continued to be stirred at -40 °C for 30 min. Upon completion of the reaction, the reaction was quenched with 10 mL of saturated aqueous ammonium chloride solution at -40 °C, followed by two extractions with ether. The organic phases were combined, washed once with saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by column chromatography (100 g silica gel, eluent heptane/ethyl acetate 19:1) to give 562 mg (49% yield) of 7-bromo-4-chloro-1H-indole as an orange oil. Mass spectral (EI) data: m/z 229.0 (80%), 231.0 (100%), 233.0 (30%) (M+).

References

[1] Patent: US2006/30613, 2006, A1. Location in patent: Page/Page column 35
[2] Patent: WO2016/16370, 2016, A1. Location in patent: Page/Page column 39; 40
[3] Patent: US2014/274695, 2014, A1. Location in patent: Paragraph 0292; 0293
[4] Patent: KR101601357, 2016, B1. Location in patent: Paragraph 0328-0330
[5] Bioorganic and Medicinal Chemistry Letters, 2000, vol. 10, # 11, p. 1223 - 1226

4-CHLORO-7-BROMOINDOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-CHLORO-7-BROMOINDOLE Suppliers

China 67 India 1 United Kingdom 1 United States 6 Global 75

Wuhan ariel chemical Co., LTD.

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View Lastest Price from 4-CHLORO-7-BROMOINDOLE manufacturers

Career Henan Chemical Co

Product: 4-CHLORO-7-BROMOINDOLE 126811-29-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KGS
Release date: 2019-12-18

126811-29-8, 4-CHLORO-7-BROMOINDOLERelated Search:

4-Bromotoluene 4-Bromoindole 6-Bromo-1H-indole 4-CHLORO-7-BROMOINDOLE

4-CHLORO-7-BROMOINDOLE

1H-Indole, 7-broMo-4-chloro-

7-Bromo-4-chloroindole

126811-29-8