4-methoxy-2,6-dimethyl-aniline
- Product Name
- 4-methoxy-2,6-dimethyl-aniline
- CAS No.
- 34743-49-2
- Chemical Name
- 4-methoxy-2,6-dimethyl-aniline
- Synonyms
- 4-methoxy-2,6-dimethyl-aniline;4-METHOXY-2,6-DIMETHYLBENZENAMINE;Benzenamine, 4-methoxy-2,6-dimethyl-
- CBNumber
- CB81514810
- Molecular Formula
- C9H13NO
- Formula Weight
- 151.21
- MOL File
- 34743-49-2.mol
4-methoxy-2,6-dimethyl-aniline Property
- Melting point:
- 36-37 °C
- Boiling point:
- 135 °C(Press: 12 Torr)
- Density
- 1.019±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 4.91±0.10(Predicted)
- Appearance
- Pale purple to brown Solid
Safety
- HS Code
- 2922290090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M337193
- Product name
- 4-Methoxy-2,6-dimethylaniline
- Packaging
- 1g
- Price
- $350
- Updated
- 2021/12/16
- Product number
- 4221AB
- Product name
- 4-Methoxy-2,6-dimethylaniline
- Packaging
- 250mg
- Price
- $101
- Updated
- 2021/12/16
- Product number
- J57248
- Product name
- 4-Methoxy-2,6-dimethylaniline
- Packaging
- 1g
- Price
- $185
- Updated
- 2021/12/16
- Product number
- 120050
- Product name
- 4-Methoxy-2,6-dimethylaniline
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $418
- Updated
- 2021/12/16
- Product number
- CHM0302172
- Product name
- 4-METHOXY-2,6-DIMETHYLANILINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.78
- Updated
- 2021/12/16
4-methoxy-2,6-dimethyl-aniline Chemical Properties,Usage,Production
Synthesis
3096-70-6
74-88-4
34743-49-2
Under argon protection, 4-amino-3,5-dimethylphenol (50 mg, 0.36 mmol) and sodium 2-methylpropan-2-ol (52 mg, 0.55 mmol) were dissolved in anhydrous DMF (1 mL). Iodomethane (0.021 mL, 0.33 mmol) was then added and the reaction mixture was stirred overnight at room temperature. After the reaction was completed, dichloromethane (20 mL) was added to dilute the reaction and washed sequentially with aqueous sodium hydroxide (2 × 15 mL) and saturated saline (2 × 15 mL). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=2/1) to afford 4-methoxy-2,6-dimethylaniline (24 mg, 43% yield). Mass spectrum (ESI+) m/z: 152.1 [M+H]+. Methyl 7-[3-(N-(4-methoxy-2,6-dimethylphenyl)aminosulfonyl)phenyl]heptanoate (12 mg, 17% yield) was synthesized by following the procedure described in Method A using 4-methoxy-2,6-dimethylaniline (24 mg, 0.16 mmol) as starting material. Mass spectrum (ESI+) m/z: 456.2 [M+Na]+. The above ester derivative (12 mg, 0.028 mmol) was hydrolyzed according to the hydrolysis conditions described in Method A to give compound 8 as an orange oil (11 mg, 95% yield).1H NMR (300 MHz, chloroform-d) δ ppm: 1.22-1.36 (m, 4H), 1.49-1.66 (m, 4H), 1.97 (s, 6H) , 2.30 (t, J=6.76 Hz, 2H), 2.61 (t, J=7.58 Hz, 2H), 3.75 (s, 3H), 6.53 (s, 1H), 7.31-7.39 (m, 3H), 7.46-7.57 (m, 3H). Mass spectrum (ESI+) m/z: 442.2 [M+Na]+.
References
[1] European Journal of Organic Chemistry, 2013, # 27, p. 6137 - 6145
[2] Patent: WO2018/208132, 2018, A1. Location in patent: Paragraph 628-632
[3] Patent: WO2018/29150, 2018, A1. Location in patent: Page/Page column 22
[4] MedChemComm, 2018, vol. 9, # 7, p. 1188 - 1193
4-methoxy-2,6-dimethyl-aniline Preparation Products And Raw materials
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View Lastest Price from 4-methoxy-2,6-dimethyl-aniline manufacturers
- Product
- 4-Methoxy-2,6-dimethylaniline 34743-49-2
- Price
- US $1.60-6.60/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-19
- Product
- 4-methoxy-2,6-dimethyl-aniline 34743-49-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-07-29