talmapimod

ChemicalBook > CAS DataBase List > talmapimod

Product Name: talmapimod
CAS No.: 309913-83-5
Chemical Name: talmapimod
Synonyms: SCIO 469;Scios 469;talmapimod;Unii-B1E00kq6nt;TalMapiMod (SCIO-469);SCIO 469 - Talmapimod;SCIO 469 hydrochloride;Talmapimod hydrochloride;TALMAPIMOD;SCIO469;SCIO 469;cytotoxicity,multiple,inhibit,tumor,SCIO 469,SCIO469,cells,Hsp27,Inhibitor,phosphorylation,Talmapimod,p38 MAPK,myeloma
CBNumber: CB81518535
Molecular Formula: C27H30ClFN4O3
Formula Weight: 513
MOL File: 309913-83-5.mol

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talmapimod Property

Boiling point:: 658.0±65.0 °C(Predicted)
Density: 1.29
storage temp.: Desiccate at +4°C
solubility: DMSO: soluble
form: A crystalline solid
pka: 6.52±0.70(Predicted)

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Safety

HS Code: 2924297099

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29484
Product name: SCIO 469
Packaging: 1mg
Price: $33
Updated: 2024/03/01

Cayman Chemical

Product number: 29484
Product name: SCIO 469
Packaging: 5mg
Price: $120
Updated: 2024/03/01

Cayman Chemical

Product number: 29484
Product name: SCIO 469
Packaging: 10mg
Price: $223
Updated: 2024/03/01

Tocris

Product number: 3528
Product name: SCIO469hydrochloride
Purity: ≥98%(HPLC)
Packaging: 10
Price: $257
Updated: 2021/12/16

Tocris

Product number: 3528
Product name: SCIO469hydrochloride
Purity: ≥98%(HPLC)
Packaging: 50
Price: $1078
Updated: 2021/12/16

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talmapimod Chemical Properties,Usage,Production

Uses

Talmapimod is a p38 mitogen-activated protein (MAP) kinase inhibitor. Talmapimod reduced human myeloma cell growth in vivo both at early and advanced phases of the disease in mouse xenograft models. Talmapimod that blocks tumor necrosis factor-α, interleukin-1β, and cyclooxygenase-2 synthesis in patients with active rheumatoid arthritis (RA)

Definition

ChEBI: An indolecarboxamide obtained by formal condensation of the carboxy group of 6-chloro-3-[(dimethylamino)(oxo)acetyl]-1-methylindole-5-carboxylic acid with the secondary amino group of (2S,5R)-1-[(4-fluorophenyl)methyl]-2, -dimethylpiperazine. It is a potent inhibitor of MAPK and exhibits anti-cancer properties.

talmapimod Preparation Products And Raw materials

Raw materials

Preparation Products

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309913-83-5, talmapimodRelated Search:

TALMAPIMOD;SCIO469;SCIO 469

SCIO 469 - Talmapimod

talmapimod

6-Chloro-5-[[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethyl-1-piperazinyl]carbonyl]-N,N,1-trimethyl-alpha-oxo-1H-indole-3-acetamide

Unii-B1E00kq6nt

6-Chloro-5-[[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethyl-1-piperazinyl]carbonyl]-N,N,1-trimethyl-α-oxo-1H-Indole-3-acetamidehydrochloride

SCIO 469 hydrochloride

6-Chloro-5-[[(2R,5S)-4-[(4-fluorophenyl)Methyl]-2,5-diMethyl-1-piperazinyl]carbonyl]-N,N,1-triMethyl-α-oxo-1H-indole-3-acetaMide

SCIO 469

Scios 469

TalMapiMod (SCIO-469)

Talmapimod hydrochloride

1H-Indole-3-acetamide, 6-chloro-5-[[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethyl-1-piperazinyl]carbonyl]-N,N,1-trimethyl-α-oxo-

cytotoxicity,multiple,inhibit,tumor,SCIO 469,SCIO469,cells,Hsp27,Inhibitor,phosphorylation,Talmapimod,p38 MAPK,myeloma

309913-83-5

C27H30ClFN4O3

C27H30ClFN4O3HCl