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Tecovirimat

Product Name
Tecovirimat
CAS No.
816458-31-8
Chemical Name
Tecovirimat
Synonyms
rel-N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-Octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl]-4-(trifluoromethyl)benzamide;tecovirimat;Special Kao Wei Rui;Tecovirimat USP/EP/BP
CBNumber
CB81518540
Molecular Formula
C19H15F3N2O3
Formula Weight
376.332
MOL File
816458-31-8.mol
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Tecovirimat Property

Melting point:
194-195 ºC
Density 
1.53
storage temp. 
-20°C Freezer
solubility 
Dichloromethane (Slightly), DMSO Slightly()
form 
Solid
color 
White to Off-White
InChI
InChI=1/C19H15F3N2O3/c20-19(21,22)9-3-1-8(2-4-9)16(25)23-24-17(26)14-10-5-6-11(13-7-12(10)13)15(14)18(24)27/h1-6,10-15H,7H2,(H,23,25)/t10-,11+,12+,13-,14-,15+
InChIKey
CSKDFZIMJXRJGH-VWLPUNTINA-N
SMILES
C(F)(C1C=CC(=CC=1)C(=O)NN1C(=O)[C@@]2([H])[C@@]([H])(C1=O)[C@@]1([H])C=C[C@]2([H])[C@]2([H])C[C@]12[H])(F)F |&1:14,16,20,24,26,29,r|
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Hazard and Precautionary Statements (GHS)

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Tecovirimat Chemical Properties,Usage,Production

Uses

Tecovirimat is an orally bioavailable antipoxvirus compound inhibits extracellular virus formation and protects mice from lethal orthopoxvirus, including vaccinia, monkeypox, camelpox, cowpox, ectromelia (mousepox), and variola viruses.

Pharmacokinetics

At the recommended oral dosage of 600 mg every 12 hours administered in healthy adults weighing less than 120 kg, the mean steady-state values of tecovirimat AUC0-24hr, Cmax, and Ctau/trough are 29816 hr?¤ng/mL (n, CV: 43, 34%), 2159 ng/mL (n, CV: 46, 32%), and 845 ng/mL (n, CV: 45, 47%), respectively. At the recommended intravenous dosage of 200 mg every 12 hours administered by IV infusion over 6 hours in healthy adults, the mean steady-state values of tecovirimat AUC0-24hr, Cmax, and Cmin are 39405 hr.ng/mL (n, CV: 22, 23%), 2630 ng/mL (n, CV: 22, 22%), and 747 ng/mL (n, CV: 22, 29%). Refer to Table 7 for pharmacokinetic parameters of tecovirimat. Tecovirimat steady-state is achieved by Day 4-6.

Side effects

Common side effects of TPOXX (Tecovirimat) include: headache, nausea, abdominal pain, and vomiting.
TPOXX (Tecovirimat) may cause serious side effects, including: hives, difficulty breathing, and swelling of your face, lips, tongue, or throat.

Tecovirimat Preparation Products And Raw materials

Raw materials

Preparation Products

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Tecovirimat Suppliers

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View Lastest Price from Tecovirimat manufacturers

S&Y Biochem Co.,Ltd
Product
Tecovirimat 816458-31-8
Price
US $1.00/g
Min. Order
1g
Purity
99
Supply Ability
1000
Release date
2024-08-22
shandong perfect biotechnology co.ltd
Product
Tecovirimat 816458-31-8
Price
US $0.00/g
Min. Order
1g
Purity
98% HPLC
Supply Ability
1kg
Release date
2023-08-02
Dideu Industries Group Limited
Product
Tecovirimat 816458-31-8
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-15

816458-31-8, TecovirimatRelated Search:

1,4-Dioxane DIOXOPROMETHAZINE HCL Selenium dioxide DIOXOPROMETHAZINE Tecovirimat

  • tecovirimat
  • rel-N-[(3aR,4R,4aR,5aS,6S,6aS)-3,3a,4,4a,5,5a,6,6a-Octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl]-4-(trifluoromethyl)benzamide
  • Tecovirimat USP/EP/BP
  • Special Kao Wei Rui
  • 816458-31-8
  • API