(S)-4-BENZYL-3-CHLOROMETHYL-MORPHOLINE

Product Name: (S)-4-BENZYL-3-CHLOROMETHYL-MORPHOLINE
CAS No.: 917572-28-2
Chemical Name: (S)-4-BENZYL-3-CHLOROMETHYL-MORPHOLINE
Synonyms: (S)-4-BENZYL-3-CHLOROMETHYL-MORPHOLINE;(3S)-4-benzyl-3-(chloromethyl)morpholine;Morpholine, 3-(chloroMethyl)-4-(phenylMethyl)-, (3S)-
CBNumber: CB81519572
Molecular Formula: C12H16ClNO
Formula Weight: 225.71
MOL File: 917572-28-2.mol

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(S)-4-BENZYL-3-CHLOROMETHYL-MORPHOLINE Property

Boiling point:: 316.1±27.0 °C(Predicted)
Density: 1.132±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 5.53±0.40(Predicted)
Appearance: Colorless to light yellow Liquid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Activate Scientific

Product number: AS116984
Product name: (S)-4-Benzyl-3-(chloromethyl)morpholine
Purity: 97+% ee
Packaging: 100mg
Price: $212
Updated: 2021/12/16

Activate Scientific

Product number: AS116984
Product name: (S)-4-Benzyl-3-(chloromethyl)morpholine
Purity: 97+% ee
Packaging: 250mg
Price: $350
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0001513
Product name: (S)-4-BENZYL-3-CHLOROMETHYL-MORPHOLINE
Purity: 95.00%
Packaging: 250MG
Price: $525
Updated: 2021/12/16

Activate Scientific

Product number: AS116984
Product name: (S)-4-Benzyl-3-(chloromethyl)morpholine
Purity: 97+% ee
Packaging: 1g
Price: $635
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0001513
Product name: (S)-4-BENZYL-3-CHLOROMETHYL-MORPHOLINE
Purity: 95.00%
Packaging: 1G
Price: $1178.79
Updated: 2021/12/16

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(S)-4-BENZYL-3-CHLOROMETHYL-MORPHOLINE Chemical Properties,Usage,Production

Synthesis

101376-26-5

917572-28-2

(a) Synthesis of (3S)-4-benzyl-3-(chloromethyl)morpholine: [(3R)-4-benzylmorpholin-3-yl]methanol (1.83 g, 8.8 mmol) was dissolved in anhydrous dichloromethane (15 mL) under argon protection. To this solution thionyl chloride (3.15 g, 26.5 mmol) and N,N-dimethylformamide (DMF, 2 drops) were added sequentially. The reaction mixture was heated to reflux with continuous stirring for 2 h 30 min. After completion of the reaction, the solvent was removed by rotary evaporator. The residue was neutralized with saturated aqueous sodium bicarbonate and subsequently extracted with ethyl acetate (3 × 15 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated to afford the oily product (3S)-4-benzyl-3-(chloromethyl)morpholine (1.88 g, 94% yield). The product was characterized by 1H NMR (500 MHz, CDCl3) and LCMS: 1H NMR (500 MHz, CDCl3) δ 2.3-2.4 (m, 1H), 2.7 (m, 1H), 2.8 (m, 1H), 3.5 (d, 1H), 3.6-3.9 (m, 5H), 4.0 (d, 1H), 7.3 (m, 1H) , 7.4 (m, 4H); LCMS: m/z 226 [M + H]+.

References

[1] Patent: WO2006/137790, 2006, A1. Location in patent: Page/Page column 32
[2] Patent: WO2006/137791, 2006, A1. Location in patent: Page/Page column 43
[3] Patent: WO2011/111875, 2011, A1. Location in patent: Page/Page column 90
[4] Journal of Medicinal Chemistry, 2017, vol. 60, # 6, p. 2227 - 2244

(S)-4-BENZYL-3-CHLOROMETHYL-MORPHOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-4-BENZYL-3-CHLOROMETHYL-MORPHOLINE Suppliers

China 28 India 1 United States 4 Global 33

J & K SCIENTIFIC LTD.

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View Lastest Price from (S)-4-BENZYL-3-CHLOROMETHYL-MORPHOLINE manufacturers

Wuhan Monad Medicine Tech Co.,LTD

Product: (3S)-4-benzyl-3-(chloromethyl)morpholine 917572-28-2
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%min
Supply Ability: 20000
Release date: 2020-12-17

Hebei shuoxi biotechnology co. LTD

Product: (3S)-4-benzyl-3-(chloromethyl)morpholine 917572-28-2
Price: US $60.00/KG
Min. Order: 1g
Purity: 99.8%
Supply Ability: 10tons
Release date: 2019-10-28

917572-28-2, (S)-4-BENZYL-3-CHLOROMETHYL-MORPHOLINERelated Search:

4-BENZYL-3-CHLOROMETHYL-MORPHOLINE (S)-4-BENZYL-3-CHLOROMETHYL-MORPHOLINE

Morpholine, 3-(chloroMethyl)-4-(phenylMethyl)-, (3S)-

(S)-4-BENZYL-3-CHLOROMETHYL-MORPHOLINE

(3S)-4-benzyl-3-(chloromethyl)morpholine

917572-28-2