Menadiol diacetate

Product Name: Menadiol diacetate
CAS No.: 573-20-6
Chemical Name: Menadiol diacetate
Synonyms: VITAMIN K4;Kapilin;ACETOMENAPHTHONE;Pafavit;Kayvite;Adaprin;Kapilon;menadio;VitavelK;Davitamon-K
CBNumber: CB8154972
Molecular Formula: C15H14O4
Formula Weight: 258.27
MOL File: 573-20-6.mol

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Menadiol diacetate Property

Melting point:: 113 °C
Boiling point:: 361.52°C (rough estimate)
Density: 1.2105 (rough estimate)
refractive index: 1.4872 (estimate)
storage temp.: Sealed in dry,Room Temperature
Water Solubility: Insoluble in water
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 1 mg/ml
form: powder to crystal
color: White to Almost white
InChI: InChI=1S/C15H14O4/c1-9-8-14(18-10(2)16)12-6-4-5-7-13(12)15(9)19-11(3)17/h4-8H,1-3H3
InChIKey: RYWSYCQQUDFMAU-UHFFFAOYSA-N
SMILES: C1(OC(=O)C)=C2C(C=CC=C2)=C(OC(=O)C)C=C1C
CAS DataBase Reference: 573-20-6(CAS DataBase Reference)

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Safety

RTECS: QJ5250000
HS Code: 2936.29.5050

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: V0103
Product name: Vitamin K4
Purity: >98.0%(GC)
Packaging: 25g
Price: $67
Updated: 2025/07/31

TRC

Product number: V680010
Product name: Vitamin K4
Packaging: 1g
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: J95696
Product name: Menadioldiacetate
Packaging: 10g
Price: $25
Updated: 2021/12/16

ApexBio Technology

Product number: C6952
Product name: MenadiolDiacetate
Packaging: 200mg
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-8181
Product name: Vitamin K4
Purity: 99.80%
Packaging: 200mg
Price: $60
Updated: 2021/12/16

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Menadiol diacetate Chemical Properties,Usage,Production

Uses

Vitamin K4, is a chemically synthesized Vitamin K which plays an important role in the normal blood coagulation system.

Definition

ChEBI: Acetomenaphthone is a member of naphthalenes.

Biological Activity

Vitamin K4 elicits anti-cancer functionality and induces apoptosis in prostate carcinoma.

Synthesis

58-27-5

108-24-7

573-20-6

General procedure for the synthesis of vitamin K4 from 2-methyl-1,4-naphthoquinone (20.0 g) and acetic anhydride (29.65 g): 2-methyl-1,4-naphthoquinone was first dissolved in ethyl acetate (200 g). Subsequently, acetic anhydride, 4-dimethylaminopyridine (DMAP, 1.42 g), and palladium/carbon catalyst (Pd/C, 0.6 g) were added to the solution. The reaction mixture was stirred at room temperature in a hydrogen atmosphere overnight. Upon completion of the reaction, the Pd/C catalyst was removed by filtration. The filtrate was washed with brine and the organic layer was separated. The organic layer was concentrated and recrystallized in a solvent mixture of water (60 g) and isopropanol (IPA, 80 g) to yield 28.0 g of vitamin K4 as white crystals (yield: 84.2%, HPLC purity: 99.8%). The structure of the compound was characterized by 1H-NMR with the following chemical shifts: δ 2.27 (s, 3H), 2.46 (s, 3H), 2.50 (s, 3H), 7.27 (s, 1H), 7.55-7.62 (m, 2H), 7.85-7.89 (d, 2H).

References

[1] Patent: WO2016/60670, 2016, A1. Location in patent: Paragraph 0036-0041
[2] Patent: TW2016/15603, 2016, A. Location in patent: Paragraph 0049-0051
[3] Journal of Crystallographic and Spectroscopic Research, 1989, vol. 19, # 2, p. 307 - 316
[4] Archiv der Pharmazie, 1973, vol. 306, # 4, p. 257 - 267

Menadiol diacetate Preparation Products And Raw materials

Raw materials

Methylnaphthalene Sodium acetate 2-Methylnaphthalene

Preparation Products

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Menadiol diacetate Suppliers

Belgium 1 Canada 1 China 245 Europe 3 France 1 Germany 2 India 4 Japan 3 South Korea 1 Switzerland 1 United Kingdom 4 United States 27 Global 293

Anhui Vanward Pharmaceutical Co., Ltd.

Tel: 021-53083188
Fax: +86 21 53081260
Country: China
ProdList: 7
Advantage: 60

Suzhou Laing Biological Technology Co., LTD

Tel: 0512-62968256 18550502935
Fax: 0512-62968256
Email: export@laingbiotec.com
Country: China
ProdList: 976
Advantage: 58

ZhengZhou HuaWen Chemical Co.Ltd

Tel: 0370-2785118 17550508557
Fax: QQ：3470079902
Email: 675141927@qq.com
Country: China
ProdList: 3199
Advantage: 55

Shandong Binchen Chemical Co.，Ltd

Tel: 13837799094
Email: 3846935277@qq.com
Country: China
ProdList: 997
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

future industrial shanghai co., ltd

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: sales@jonln.com
Country: China
ProdList: 1995
Advantage: 65

New Energy Chemicals

Tel: 0515-82159099 13770142076
Fax: 86-0515-8215909
Email: info@njuchem.com
Country: China
ProdList: 242
Advantage: 65

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

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View Lastest Price from Menadiol diacetate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Menadiol diacetate/Vitamin K4 573-20-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%min
Supply Ability: 500KGS
Release date: 2021-06-15

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: Vitamin K Diacetate 573-20-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2024-04-01

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: Vitamin K4 Menadiol Diacetate 573-20-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2024-04-01

573-20-6, Menadiol diacetateRelated Search:

Kresoxim-methyl Pyridoxine hydrochloride 3-Hydroxy-2-methyl-4H-pyran-4-one Vitamin E Bensulfuron methyl Menadione 2,6-DIMETHYLNAPHTHALENE Methyl acrylate B12 VITAMIN B12 2-Methylnaphthalene Methyl eugenol Pancuronium bromide Methylparaben METHYL THIOPHENE-2-CARBOXYLATE Methyl acetate Thiophanate-methyl Vitamin A Cresol

1,4-Naphthalenediol,2-methyl-,diacetate

Kayvite

Pafavit

Prokayvitoral

VitaminKdiacetate

VitavelK

ACETOMENAPHTHONE

MENADIOL DIACETATE

VITAMIN K4

VITAMIN K4 DIACETATE

1,4-DIACETOXY-2-METHYLNAPHTHALENE

2-METHYL-1,4-NAPHTHOHYDROQUINONE DIACETATE

2-methyl-1,4-naphthalenediol diacetate

acetic acid (4-acetyloxy-3-methyl-1-naphthalenyl) ester

2-Methylnaphthalene-1,4-diyl diacetate, ≥98%,HPLC

4-naphthalenediol,2-methyl-diacetate

Adaprin

Davitamon-K

Davitamon-K-oral

Kapilin

Kapilon

Kativpowder

MENADIOL ACETATE CP2000 99.0+%

MenadiolDiacetateVitaminK4

VitaminK4,Menadiol

Vitamin K<sub>4</sub>

Menadiol Acetate

1,4 diacetoxy 2-methyl naphthalene,Menadiol Diacetate

2-Methylnaphthalene-1,4-diyl diacetate

1,4-Naphthalenediol,2-Methyl-, 1,4-diacetate

(4-acetyloxy-2-methylnaphthalen-1-yl) acetate

(4-acetyloxy-2-methyl-naphthalen-1-yl) ethanoate

acetic acid (4-acetoxy-2-methyl-1-naphthyl) ester

menadio

Acetomenaphthone (Menadiol Diacetat

Menadiol diacetate USP/EP/BP

Vitamin K4 (Acetomenaphthone)

Acetomenaphthone (Menadiol Diacetate)

Vitamin K1 Impurity 14 (Vitamin K4)

Vitamin K4, ≥ 98.0%

Vitamin K4 Menadiol Diacetate

Vitamin K1 Impurity 97

Vitamin K4, 10 mM in DMSO

2-Methylphthalene-1,4-diyl diacetate

573-20-6

4573-20-6

CH3C10H5COOCH32

C10H5OCOCH32CH3

Vitamins and derivatives

Inhibitors

Biochemistry

Vitamins