ChemicalBook > CAS DataBase List > (2-Trifluoromethyl-pyridin-3-yl)-methanol

(2-Trifluoromethyl-pyridin-3-yl)-methanol

Product Name
(2-Trifluoromethyl-pyridin-3-yl)-methanol
CAS No.
131747-57-4
Chemical Name
(2-Trifluoromethyl-pyridin-3-yl)-methanol
Synonyms
2-(Trifluoromethyl)pyridine-3-methanol;2-(Trifluoromethyl)-3-pyridinemethanol;2-(trifluoromethyl)-3-pyridyl]methanol;3-pyridineMethanol, 2-(trifluoroMethyl)-;(2-Trifluoromethyl-pyridin-3-yl)-methanol;(2-trifluoromethyl pyridine-3-yl) -methanol
CBNumber
CB81553840
Molecular Formula
C7H6F3NO
Formula Weight
177.12
MOL File
131747-57-4.mol
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(2-Trifluoromethyl-pyridin-3-yl)-methanol Property

Boiling point:
209℃
Density 
1.362
Flash point:
80℃
storage temp. 
Sealed in dry,Room Temperature
pka
13.08±0.10(Predicted)
Appearance
Light yellow to yellow Solid
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
T791160
Product name
(2-(Trifluoromethyl)pyridin-3-yl)methanol
Packaging
500mg
Price
$130
Updated
2021/12/16
Apolloscientific
Product number
PC905183
Product name
(2-(Trifluoromethyl)pyridin-3-yl)methanol
Purity
95%
Packaging
1g
Price
$135
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
T11120
Product name
2-(Trifluoromethyl)-3-pyridinemethanol
Packaging
5g
Price
$160
Updated
2021/12/16
Activate Scientific
Product number
AS147669
Product name
(2-(Trifluoromethyl)pyridin-3-yl)methanol
Purity
95%
Packaging
1g
Price
$189
Updated
2021/12/16
AK Scientific
Product number
Y7404
Product name
2-(Trifluoromethyl)-3-pyridinemethanol
Packaging
5g
Price
$424
Updated
2021/12/16
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(2-Trifluoromethyl-pyridin-3-yl)-methanol Chemical Properties,Usage,Production

Synthesis

208517-35-5

131747-57-4

General procedure for the synthesis of (2-trifluoromethyl-pyridin-3-yl)-methanol from ethyl 2-trifluoromethylnicotinate: sodium borohydride (0.35 g, 9.1 mmol) was suspended in anhydrous tetrahydrofuran (20 mL). Anhydrous tetrahydrofuran solution (20 mL) of ethyl 2-trifluoromethylnicotinate (1.00 g, 0.46 mmol) was added dropwise to the stirred suspension under ice bath cooling. The reaction mixture was stirred at 4°C for 16 hours. Upon completion of the reaction, methanol (5 mL) was added to quench the residual sodium borohydride, followed by the addition of 15% aqueous sodium hydroxide solution (25 mL). The resulting mixture was continued to be stirred at 25 °C for 30 min, followed by removal of tetrahydrofuran and methanol by rotary evaporation. The remaining aqueous phase was extracted with ethyl acetate (3 x 25 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated by rotary evaporation to afford the target product (2-trifluoromethyl-pyridin-3-yl)-methanol as a yellow oil (0.61 g, 75% yield), which could be used in subsequent reactions without further purification. The product was characterized by 1H-NMR (CDCl3): δ 8.64 (d, J = 4.5 Hz, 1H), 8.17 (d, J = 8.0 Hz, 1H), 7.57 (dd, J = 8.0, 4.5 Hz, 1H), 4.98 (s, 2H), 1.99 (s, 1H). Mass spectrum (ESI+): m/z (M + H)+ = 178.

References

[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 17, p. 5352 - 5359
[2] Journal of Medicinal Chemistry, 1998, vol. 41, # 12, p. 2146 - 2163
[3] Synthesis, 2005, # 16, p. 2751 - 2757
[4] Patent: WO2015/187934, 2015, A1. Location in patent: Paragraph 0228

(2-Trifluoromethyl-pyridin-3-yl)-methanol Preparation Products And Raw materials

Raw materials

Preparation Products

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131747-57-4, (2-Trifluoromethyl-pyridin-3-yl)-methanolRelated Search:

2-(Trifluoromethyl)nicotinic acid ETHYL 5-CYANO-6-METHYL-2-(TRIFLUOROMETHYL)NICOTINATE ETHYL 2-CHLORO-3-CYANO-6-(TRIFLUOROMETHYL)-PYRIDINE-5-CARBOXYLATE DIETHYL 3-AMINO-6-(TRIFLUOROMETHYL)THIENO[2,3-B]PYRIDINE-2,5-DICARBOXYLATE 6-METHYL-5-(4-PHENYL-1,3-THIAZOL-2-YL)-2-(TRIFLUOROMETHYL)NICOTINIC ACID 2-(TRIFLUOROMETHYL)-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID 2-(TRIFLUOROMETHYL)-1,6-NAPHTHYRIDINE-3-CARBOXYLIC ACID 1,8-Naphthyridine-3-carboxylicacid,2-(trifluoromethyl)-,ethylester(9CI) 5-(TRIFLUOROMETHYL)THIENO[3,2-B]PYRIDINE-6-CARBOXYLICACID 2-(TRIFLUOROMETHYL)-1,6-NAPHTHYRIDINE-3-CARBOXYLIC ETHYL ESTER 6-HYDROXY-5-(2-HYDROXYBENZOYL)-2-(TRIFLUOROMETHYL)NICOTINIC ACID DIETHYL 2-METHYL-6-(TRIFLUOROMETHYL)PYRIDINE-3,5-DICARBOXYLATE 2-(DIFLUOROMETHYL)-4-(2-METHYLPROPYL)-6-(TRIFLUOROMETHYL)-3,5-PYRIDINEDICARBOXYLIC ACID, 5-METHYL ESTER ETHYL 5-CYANO-6-([2-(([(2,6-DICHLORO-4-PYRIDYL)AMINO]CARBONYL)AMINO)PHENYL]THIO)-2-(TRIFLUOROMETHYL)NICOTINATE 5-(TRIFLUOROMETHYL)THIENO[3,2-B]PYRIDINE-6-CARBOXYLIC ACID, ETHYL ESTER BUTTPARK 82\12-87 5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID ETHYL 5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXYLATE

  • (2-Trifluoromethyl-pyridin-3-yl)-methanol
  • 2-(Trifluoromethyl)-3-pyridinemethanol
  • 2-(Trifluoromethyl)pyridine-3-methanol
  • 3-pyridineMethanol, 2-(trifluoroMethyl)-
  • 2-(trifluoromethyl)-3-pyridyl]methanol
  • (2-trifluoromethyl pyridine-3-yl) -methanol
  • 131747-57-4
  • Building Blocks
  • Pyridine