2-bromo-1-(4-bromo-2-fluorophenyl)ethanone

2-bromo-1-(4-bromo-2-fluorophenyl)ethanone Property

Boiling point:

306.7±32.0 °C(Predicted)

Density 

1.914±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

crystalline powder

color 

White

Safety

HS Code 

2914790090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

2-bromo-1-(4-bromo-2-fluorophenyl)ethanone Chemical Properties,Usage,Production

Synthesis

Step 3: A solution of 2-bromo-1-(4-bromo-2-fluorophenyl)ethanone bromide (1.2 mL, 23.0 mmol) in 10 mL of glacial acetic acid was slowly added dropwise to a solution of 1-(4-bromo-2-fluorophenyl)ethanone (5.0 g, 23.0 mmol) in 150 mL of anhydrous methylene chloride, and the reaction was carried out at 0°C. After dropwise addition, the reaction mixture was slowly warmed up to room temperature. The progress of the reaction was monitored by TLC (unfolding agent: 5% ethyl acetate/hexane) to confirm complete consumption of the feedstock. The reaction mixture was diluted with dichloromethane and washed sequentially with 5% sodium thiosulfate solution and saturated saline. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford 2-bromo-1-(4-bromo-2-fluorophenyl)ethanone (6.6 g, 97% yield) as a light green oil.

References

[1] Patent: US2008/45556, 2008, A1. Location in patent: Page/Page column 32-33
[2] Patent: WO2012/125926, 2012, A2. Location in patent: Page/Page column 79
[3] Patent: WO2012/122716, 2012, A1. Location in patent: Page/Page column 98
[4] Patent: CN107629023, 2018, A. Location in patent: Paragraph 0199; 0202; 0203; 0204
[5] Patent: CN107629022, 2018, A. Location in patent: Paragraph 0311; 0312; 0313; 0314