C-(5-Trifluoromethyl-pyridin-3-yl)-methylamine
- Product Name
- C-(5-Trifluoromethyl-pyridin-3-yl)-methylamine
- CAS No.
- 766513-53-5
- Chemical Name
- C-(5-Trifluoromethyl-pyridin-3-yl)-methylamine
- Synonyms
- 5-(Trifluoromethyl)-3-pyridinemethanamine;5-(Trifluoromethyl)pyridine-3-methanamine;3-Pyridinemethanamine, 5-(trifluoromethyl)-;1-[5-(trifluoromethyl)pyridin-3-yl]methanamine;C-(5-Trifluoromethyl-pyridin-3-yl)-methylamine;(5-(trifluoromethyl) pyridine-3-yl) methylamine
- CBNumber
- CB81560473
- Molecular Formula
- C7H7F3N2
- Formula Weight
- 176.14
- MOL File
- 766513-53-5.mol
C-(5-Trifluoromethyl-pyridin-3-yl)-methylamine Property
- Boiling point:
- 208.0±35.0 °C(Predicted)
- Density
- 1.293±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 7.85±0.29(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H227Combustible liquid
H314Causes severe skin burns and eye damage
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- HCH0064010
- Product name
- (5-(TRIFLUOROMETHYL)PYRIDIN-3-YL)METHANAMINE
- Purity
- 95.00%
- Packaging
- 2G
- Price
- $2021.25
- Updated
- 2021/12/16
- Product number
- CD11060214
- Product name
- (5-(Trifluoromethyl)pyridin-3-yl)methanamine
- Purity
- 97%
- Packaging
- 25g
- Price
- $3329
- Updated
- 2021/12/16
- Product number
- CD11060214
- Product name
- (5-(Trifluoromethyl)pyridin-3-yl)methanamine
- Purity
- 97%
- Packaging
- 100mg
- Price
- $99
- Updated
- 2021/12/16
- Product number
- CD11060214
- Product name
- (5-(Trifluoromethyl)pyridin-3-yl)methanamine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $158
- Updated
- 2021/12/16
- Product number
- CM172168
- Product name
- (5-(trifluoromethyl)pyridin-3-yl)methanamine
- Purity
- 97%
- Packaging
- 1g
- Price
- $375
- Updated
- 2021/12/16
C-(5-Trifluoromethyl-pyridin-3-yl)-methylamine Chemical Properties,Usage,Production
Synthesis
624734-22-1
766513-53-5
General procedure for the synthesis of 5-trifluoromethylpyridine-3-methanamine from 2-chloro-5-(trifluoromethyl)nicotinonitrile: Nickel Nguyenay (300 mg) was added to a mixture of ethanol (40 ml) and ammonium hydroxide (5 ml) of the product of step D (1 g, 4.9 mmol). The reaction mixture was subjected to hydrogenation at 40°C with hydrogen pressure kept constant and the reaction lasted for 7 hours. After completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under vacuum. The residue was purified by medium pressure liquid chromatography (MPLC, Biotage Flash 40 system) using a CH2Cl2 solution of 2% CH3OH containing 0.5% NH4OH as eluent, resulting in the target product 5-trifluoromethylpyridine-3-methylamine (250 mg, 30% yield). The structure of the product was confirmed by 1H NMR (500 MHz, CDCl3): δ = 4.00 (2H, s), 7.95 (1H, s), 8.75 (2H, d, J = 5.26 Hz).
References
[1] Patent: WO2005/14537, 2005, A2. Location in patent: Page 54
[2] Patent: WO2008/48540, 2008, A2. Location in patent: Page/Page column 39
C-(5-Trifluoromethyl-pyridin-3-yl)-methylamine Preparation Products And Raw materials
Raw materials
Preparation Products
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