1-Chloro-5-isoquinolinesulfonyl Chloride
- Product Name
- 1-Chloro-5-isoquinolinesulfonyl Chloride
- CAS No.
- 141519-77-9
- Chemical Name
- 1-Chloro-5-isoquinolinesulfonyl Chloride
- Synonyms
- 1-chloro-isoquinolin-5-sulfonyl chloride;1-Chloroisoquinoline-5-sulfonyl Chloride;1-Chloro-5-isoquinolinesulfonyl Chloride;5-Isoquinolinesulfonyl chloride, 1-chloro-
- CBNumber
- CB81564941
- Molecular Formula
- C9H5Cl2NO2S
- Formula Weight
- 262.11
- MOL File
- 141519-77-9.mol
1-Chloro-5-isoquinolinesulfonyl Chloride Property
- Boiling point:
- 405.1±30.0 °C(Predicted)
- Density
- 1.584±0.06 g/cm3(Predicted)
- storage temp.
- Storage temp. 2-8°C
- solubility
- Chloroform, Dichloromethane
- form
- Solid
- pka
- -0.24±0.43(Predicted)
- color
- Off-White
Safety
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C367600
- Product name
- 1-Chloro-5-isoquinolinesulfonylChloride
- Packaging
- 250mg
- Price
- $235
- Updated
- 2021/12/16
- Product number
- C367600
- Product name
- 1-Chloro-5-isoquinolinesulfonylChloride
- Packaging
- 2.5g
- Price
- $1890
- Updated
- 2021/12/16
- Product number
- FC20125
- Product name
- 1-Chloro-5-isoquinolinesulfonyl chloride
- Packaging
- 5G
- Price
- $2060
- Updated
- 2021/12/16
- Product number
- 8350
- Product name
- 1-Chloro-5-isoquinolinesulfonylChloride
- Packaging
- 1.25g
- Price
- $2120
- Updated
- 2021/12/16
- Product number
- HCH0010077
- Product name
- 1-CHLORO-5-ISOQUINOLINESULFONYL CHLORIDE
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $2695
- Updated
- 2021/12/16
1-Chloro-5-isoquinolinesulfonyl Chloride Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Uses
1-Chloro-5-isoquinolinesulfonyl Chloride (cas# 141519-77-9) is a compound useful in organic synthesis.
Synthesis
7790-94-5
19493-44-8
141519-77-9
Chlorosulfonic acid (40 mL) was added slowly and dropwise to 1-chloroisoquinoline (9.92 g, 60.6 mmol) under nitrogen protection and at 0 °C under stirring. The reaction mixture was then heated at 155 °C for 24 hours. After completion of the reaction, the mixture was cooled to room temperature and slowly poured into ice (200 g). After cooling, the mixture was extracted with dichloromethane (300 mL). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 13.6 g of 1-chloroisoquinoline-5-sulfonyl chloride as a white powder (51.9 mmol, 86% yield).1H NMR (CDCl3): δ 7.87 (t, J = 7.5 Hz, 1H), 8.52 (d, J = 6.2 Hz, 1H), 8.59 (d, J = 6.2 Hz, 1H ), 8.62 (d, J = 7.5 Hz, 1H), 8.82 (d, J = 7.5 Hz, 1H). Powdered 1-chloroisoquinoline-5-sulfonyl chloride (10.0 g, 38.2 mmol) was added batchwise to a stirred solution of tert-butyl (2-aminoethyl)-carbamate (7.33 g, 45.8 mmol) and triethylamine (10.7 mL, 76.4 mmol) in anhydrous dichloromethane (200 mL) at 0 °C. After the reaction mixture was stirred at room temperature for 4 h, it was concentrated and purified by silica gel column chromatography (elution gradient: dichloromethane solution in 0-5% methanol) to give 13.8 g of the product in foam form (35.8 mmol, 94% yield).ESIMS: m/z 386 [(M + H)+, 35Cl], 388 [(M + H)+, 37Cl]. Elemental analysis C16H20ClN3O4S: Calculated: C, 49.80; H, 5.22; N, 10.89; Measured: C, 49.70; H, 5.22; N, 10.72.
References
[1] Patent: WO2004/94386, 2004, A1. Location in patent: Page 27
1-Chloro-5-isoquinolinesulfonyl Chloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Chloro-5-isoquinolinesulfonyl Chloride manufacturers
- Product
- 1-chloroisoquinoline-5-sulfonyl chloride 141519-77-9
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2020-02-11