racFTY720 Phosphate
- Product Name
- racFTY720 Phosphate
- CAS No.
- 402615-91-2
- Chemical Name
- racFTY720 Phosphate
- Synonyms
- FTY720 Phosphate;FingoliMod phosphate;FTY-P;FTY720-P;FTY-P-d4;FTY720-P-d4;racFTY720 Phosphate;Fingolimod Impurity 12;FingoliMod phosphate D4;rac FTY720-d4 Phosphate
- CBNumber
- CB81565180
- Molecular Formula
- C19H34NO5P
- Formula Weight
- 387.45
- MOL File
- 402615-91-2.mol
racFTY720 Phosphate Property
- Melting point:
- 122-124°C
- Boiling point:
- 584.2±60.0 °C(Predicted)
- Density
- 1.172±0.06 g/cm3(Predicted)
- storage temp.
- Hygroscopic, -20°C Freezer, Under Inert Atmosphere
- solubility
- Chloroform : Methanol (Slightly, Heated), Methanol (Slightly, Heated)
- pka
- 1.73±0.10(Predicted)
- form
- Solid
- color
- White to Off-White
- Stability:
- Hygroscopic
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H311Toxic in contact with skin
H331Toxic if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P310Immediately call a POISON CENTER or doctor/physician.
P330Rinse mouth.
P361Remove/Take off immediately all contaminated clothing.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 10008639
- Product name
- FTY720 Phosphate
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $106
- Updated
- 2024/03/01
- Product number
- 10008639
- Product name
- FTY720 Phosphate
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $467
- Updated
- 2024/03/01
- Product number
- 10008639
- Product name
- FTY720 Phosphate
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $826
- Updated
- 2024/03/01
- Product number
- 10008639
- Product name
- FTY720 Phosphate
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $1805
- Updated
- 2024/03/01
- Product number
- 474100
- Product name
- FTY720 Phosphate
- Packaging
- 100mg
- Price
- $1253
- Updated
- 2021/12/16
racFTY720 Phosphate Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
Labelled rac FTY720 (F805010). rac FTY720 is a sphingosine 1-phosphate receptor modular, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration.
Definition
ChEBI: Fingolimod phosphate is a primary amino compound that is fingolimod in which one on the hydroxy groups has been converted into its dihydrogen phosphate derivative. It is the active metabolite of fingolimod. It has a role as an antineoplastic agent, an immunosuppressive agent and a sphingosine-1-phosphate receptor agonist. It is a monoalkyl phosphate, a primary amino compound and a primary alcohol. It is functionally related to a fingolimod.
Biological Activity
fty720 is sphingosine-1-phosphate (s1p) receptors agonist [1]. fty720 is a novel immunomodulatory agent derived from isp-1 (myriocin), a fungal metabolite that exists in traditional chinese herbal medicine. in higher eukaryotes, s1p is the ligand for five g-protein-coupled receptors. these s1p receptors are differentially expressed and regulate vascular maturation, angiogenesis, cardiac development and immunity. s1p receptors are important for directed cell movement [2].
in vitro
the phosphorylated fty720 acted as agonist for a family of g protein-coupled receptors in vitro. fty720 inhibited sphingosine-1-phosphate lyase activity [3]. fty720 phosphate acted as a potent agonist at sphingosine-1-phosphate (s1p) receptors s1p1, s1p3, s1p4, and s1p5 with ic50 values of 0.2-6 nm [3].
in vivo
in a variety of transplant and autoimmune models, fty720 was efficacious without inducing a generalized immunosuppressed state. fty720 was effective in human kidney transplantation. fty720 elicited lymphopenia resulting from a reversible redistribution of lymphocytes from circulation to secondary lymphoid tissues by unknown mechanisms. in a rodent model of multiple sclerosis, the phosphorylated fty720 compound was a potent agonist at four s s1p receptors. phosphorylation of fty720 acted through sphingosine 1-phosphate signaling pathways to modulate chemotactic responses and lymphocyte trafficking [1]. fty720 was phosphorylated in vivo. in mice, treatment with fty720 inhibited tissue sphingosine-1-phosphate lyase activity, whereas lyase gene and protein expression were not significantly affected [3].
References
[1] brinkmann v, davis m d, heise c e, et al. the immune modulator fty720 targets sphingosine 1-phosphate receptors[j]. journal of biological chemistry, 2002, 277(24): 21453-21457.
[2] spiegel s, milstien s. sphingosine-1-phosphate: an enigmatic signalling lipid[j]. nature reviews molecular cell biology, 2003, 4(5): 397-407.
[3] bandhuvula p, tam y y, oskouian b, et al. the immune modulator fty720 inhibits sphingosine-1-phosphate lyase activity[j]. journal of biological chemistry, 2005, 280(40): 33697-33700.
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