racFTY720 Phosphate
- Product Name
- racFTY720 Phosphate
- CAS No.
- 402615-91-2
- Chemical Name
- racFTY720 Phosphate
- Synonyms
- FTY720 Phosphate;FingoliMod phosphate;FTY-P;FTY720-P;FTY-P-d4;FTY720-P-d4;acFTY720 Phosphate;racFTY720 Phosphate;Fingolimod Impurity 12;FingoliMod phosphate D4
- CBNumber
- CB81565180
- Molecular Formula
- C19H34NO5P
- Formula Weight
- 387.45
- MOL File
- 402615-91-2.mol
racFTY720 Phosphate Property
- Melting point:
- 122-124°C
- Boiling point:
- 584.2±60.0 °C(Predicted)
- Density
- 1.172±0.06 g/cm3(Predicted)
- storage temp.
- Hygroscopic, -20°C Freezer, Under Inert Atmosphere
- solubility
- Chloroform : Methanol (Slightly, Heated), Methanol (Slightly, Heated)
- pka
- 1.73±0.10(Predicted)
- form
- Solid
- color
- White to Off-White
- Stability:
- Hygroscopic
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H311Toxic in contact with skin
H331Toxic if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P310Immediately call a POISON CENTER or doctor/physician.
P330Rinse mouth.
P361Remove/Take off immediately all contaminated clothing.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 10008639
- Product name
- FTY720 Phosphate
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $106
- Updated
- 2024/03/01
- Product number
- 10008639
- Product name
- FTY720 Phosphate
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $467
- Updated
- 2024/03/01
- Product number
- 10008639
- Product name
- FTY720 Phosphate
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $826
- Updated
- 2024/03/01
- Product number
- 10008639
- Product name
- FTY720 Phosphate
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $1805
- Updated
- 2024/03/01
- Product number
- 474100
- Product name
- FTY720 Phosphate
- Packaging
- 100mg
- Price
- $1253
- Updated
- 2021/12/16
racFTY720 Phosphate Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
Labelled rac FTY720 (F805010). rac FTY720 is a sphingosine 1-phosphate receptor modular, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration.
Definition
ChEBI: Fingolimod phosphate is a primary amino compound that is fingolimod in which one on the hydroxy groups has been converted into its dihydrogen phosphate derivative. It is the active metabolite of fingolimod. It has a role as an antineoplastic agent, an immunosuppressive agent and a sphingosine-1-phosphate receptor agonist. It is a monoalkyl phosphate, a primary amino compound and a primary alcohol. It is functionally related to a fingolimod.
Biological Activity
fty720 is sphingosine-1-phosphate (s1p) receptors agonist [1]. fty720 is a novel immunomodulatory agent derived from isp-1 (myriocin), a fungal metabolite that exists in traditional chinese herbal medicine. in higher eukaryotes, s1p is the ligand for five g-protein-coupled receptors. these s1p receptors are differentially expressed and regulate vascular maturation, angiogenesis, cardiac development and immunity. s1p receptors are important for directed cell movement [2].
in vitro
the phosphorylated fty720 acted as agonist for a family of g protein-coupled receptors in vitro. fty720 inhibited sphingosine-1-phosphate lyase activity [3]. fty720 phosphate acted as a potent agonist at sphingosine-1-phosphate (s1p) receptors s1p1, s1p3, s1p4, and s1p5 with ic50 values of 0.2-6 nm [3].
in vivo
in a variety of transplant and autoimmune models, fty720 was efficacious without inducing a generalized immunosuppressed state. fty720 was effective in human kidney transplantation. fty720 elicited lymphopenia resulting from a reversible redistribution of lymphocytes from circulation to secondary lymphoid tissues by unknown mechanisms. in a rodent model of multiple sclerosis, the phosphorylated fty720 compound was a potent agonist at four s s1p receptors. phosphorylation of fty720 acted through sphingosine 1-phosphate signaling pathways to modulate chemotactic responses and lymphocyte trafficking [1]. fty720 was phosphorylated in vivo. in mice, treatment with fty720 inhibited tissue sphingosine-1-phosphate lyase activity, whereas lyase gene and protein expression were not significantly affected [3].
References
[1] brinkmann v, davis m d, heise c e, et al. the immune modulator fty720 targets sphingosine 1-phosphate receptors[j]. journal of biological chemistry, 2002, 277(24): 21453-21457.
[2] spiegel s, milstien s. sphingosine-1-phosphate: an enigmatic signalling lipid[j]. nature reviews molecular cell biology, 2003, 4(5): 397-407.
[3] bandhuvula p, tam y y, oskouian b, et al. the immune modulator fty720 inhibits sphingosine-1-phosphate lyase activity[j]. journal of biological chemistry, 2005, 280(40): 33697-33700.
racFTY720 Phosphate Preparation Products And Raw materials
Raw materials
Preparation Products
racFTY720 Phosphate Suppliers
- Tel
- +86-0371-55074660
- Lingzhiyue@aliyun.com
- Country
- China
- ProdList
- 4739
- Advantage
- 58
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 0512-68716880 19984816880
- Fax
- 18075373931
- sales@growingchem.com
- Country
- China
- ProdList
- 192
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 021-64609169 18901607656
- Fax
- 021-64609160
- greensnown@163.com
- Country
- China
- ProdList
- 9906
- Advantage
- 50
- Tel
- +86-400-002-6226 +86-13028896684;
- sales@rrkchem.com
- Country
- China
- ProdList
- 57423
- Advantage
- 58
- Tel
- +86-0571-85134551
- Fax
- 008657185134895
- sales@afinechem.com
- Country
- China
- ProdList
- 15352
- Advantage
- 58
- Tel
- 020-36607679 17825480238
- Fax
- QQ 3008233717
- 3008233746@qq.com
- Country
- China
- ProdList
- 9919
- Advantage
- 12
- Tel
- 0512-68716880 19984816880
- Fax
- 0556-5282330
- sales@growingchem.com
- Country
- China
- ProdList
- 306
- Advantage
- 58
- Tel
- 86-21-50800795
- info@shochem.com
- Country
- CHINA
- ProdList
- 288
- Advantage
- 58
- Tel
- 2710913286@.com
- 1513643261@qq.com
- Country
- China
- ProdList
- 14246
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11218
- Advantage
- 58
- Tel
- 027-59207796 13429867250
- Fax
- 027-59207796
- w13429867250@163.com
- Country
- China
- ProdList
- 1987
- Advantage
- 58
- Tel
- 025-85560043 15850508050
- Fax
- 025-85563444
- info@synzest.com
- Country
- China
- ProdList
- 9286
- Advantage
- 58
- Tel
- 027-52344656 15871722230
- Fax
- 2796190295
- 15871722230@163.com
- Country
- China
- ProdList
- 4899
- Advantage
- 58
- Tel
- +86-02787215551 +86-19945035818
- Fax
- 027-87215551
- 2936752263@qq.com
- Country
- China
- ProdList
- 7977
- Advantage
- 58
- Tel
- 0755-66853366; 13670046396
- ORDERS@QCSRM.COM
- Country
- China
- ProdList
- 24342
- Advantage
- 58
- Tel
- 027-59626688 18771149750
- sales@amyjet.com
- Country
- China
- ProdList
- 3003
- Advantage
- 58
- Tel
- 15071299552
- Fax
- QQ:262933239
- 262933239@qq.com
- Country
- China
- ProdList
- 6887
- Advantage
- 58
- Tel
- 18351873721
- helen.zhang@synzest.com
- Country
- China
- ProdList
- 8295
- Advantage
- 58
- Tel
- +86-027-59232304 15387063101
- 2881924050@qq.com
- Country
- China
- ProdList
- 9956
- Advantage
- 58
- Tel
- 13339985473
- C13339985473@163.com
- Country
- China
- ProdList
- 4920
- Advantage
- 58
- Tel
- 0371-0371-53399770 18037166334
- 2853031800@qq.com
- Country
- China
- ProdList
- 3229
- Advantage
- 58
- Tel
- 021-50706066 15221275939
- shenlinxing@macklin.cn
- Country
- China
- ProdList
- 29885
- Advantage
- 58
- Tel
- 17762444226
- d17762444226@163.com
- Country
- China
- ProdList
- 2402
- Advantage
- 58
- Tel
- 18171815831
- 1341138380@qq.com
- Country
- China
- ProdList
- 3401
- Advantage
- 58
- Tel
- 021-58000709 15900491054
- info@scrbio.com
- Country
- China
- ProdList
- 10329
- Advantage
- 58
- Tel
- 13720134139 13720134139
- orders@jknbiochem.com
- Country
- China
- ProdList
- 5820
- Advantage
- 58
- Tel
- 14760821013 13564957716
- 1816280386@qq.com
- Country
- China
- ProdList
- 7910
- Advantage
- 58
- Tel
- 021-67187366 19901745723
- info@bwtlab.com
- Country
- China
- ProdList
- 9284
- Advantage
- 58
- Tel
- 18162595016; 18162595016
- 3287908757@qq.com
- Country
- China
- ProdList
- 9122
- Advantage
- 58
- Tel
- 0551-18956023141 18956023141
- 402974597@qq.com
- Country
- China
- ProdList
- 144
- Advantage
- 58
- Tel
- 025-85560043 15850508050
- Fax
- 025-85563444
- rose.shi@synzest.com
- Country
- China
- ProdList
- 6210
- Advantage
- 58
- Tel
- +86-18521732826
- market@aladdin-e.com
- Country
- China
- ProdList
- 48461
- Advantage
- 58
- Tel
- 18616537568
- hanfangpharma@126.com
- Country
- China
- ProdList
- 29971
- Advantage
- 58
- Tel
- 17316404525
- 209533805@qq.com
- Country
- China
- ProdList
- 9765
- Advantage
- 58
- Tel
- 18915538011
- liwei@boyanpharma.com
- Country
- China
- ProdList
- 102
- Advantage
- 58
- Tel
- +8613720134139
- orders@jknbiochem.com
- Country
- China
- ProdList
- 5221
- Advantage
- 58
- Tel
- +86-852-30606658
- market18@leapchem.com
- Country
- China
- ProdList
- 43340
- Advantage
- 58
- Tel
- +8618327326525
- masar@topule.com
- Country
- China
- ProdList
- 8467
- Advantage
- 58
- Tel
- +8615391658522
- overseasales@yongstandards.com
- Country
- China
- ProdList
- 11922
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@zzsrm.com
- Country
- CHINA
- ProdList
- 6650
- Advantage
- 58