ChemicalBook > CAS DataBase List > racFTY720 Phosphate

racFTY720 Phosphate

Product Name: racFTY720 Phosphate
CAS No.: 402615-91-2
Chemical Name: racFTY720 Phosphate
Synonyms: FTY720 Phosphate;FingoliMod phosphate;FTY-P;FTY720-P;FTY-P-d4;FTY720-P-d4;acFTY720 Phosphate;racFTY720 Phosphate;Fingolimod Impurity 12;FingoliMod phosphate D4
CBNumber: CB81565180
Molecular Formula: C19H34NO5P
Formula Weight: 387.45
MOL File: 402615-91-2.mol

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racFTY720 Phosphate Property

Melting point:: 122-124°C
Boiling point:: 584.2±60.0 °C(Predicted)
Density: 1.172±0.06 g/cm3(Predicted)
storage temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility: Chloroform : Methanol (Slightly, Heated), Methanol (Slightly, Heated)
pka: 1.73±0.10(Predicted)
form: Solid
color: White to Off-White
Stability:: Hygroscopic
InChI: InChI=1S/C19H34NO5P/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-25-26(22,23)24/h9-12,21H,2-8,13-16,20H2,1H3,(H2,22,23,24)
InChIKey: LRFKWQGGENFBFO-UHFFFAOYSA-N
SMILES: C(OP(O)(O)=O)C(N)(CCC1=CC=C(CCCCCCCC)C=C1)CO

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H331Toxic if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P310Immediately call a POISON CENTER or doctor/physician.

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10008639
Product name: FTY720 Phosphate
Purity: ≥98%
Packaging: 1mg
Price: $106
Updated: 2024/03/01

Cayman Chemical

Product number: 10008639
Product name: FTY720 Phosphate
Purity: ≥98%
Packaging: 5mg
Price: $467
Updated: 2024/03/01

Cayman Chemical

Product number: 10008639
Product name: FTY720 Phosphate
Purity: ≥98%
Packaging: 10mg
Price: $826
Updated: 2024/03/01

Cayman Chemical

Product number: 10008639
Product name: FTY720 Phosphate
Purity: ≥98%
Packaging: 25mg
Price: $1805
Updated: 2024/03/01

Usbiological

Product number: 474100
Product name: FTY720 Phosphate
Packaging: 100mg
Price: $1253
Updated: 2021/12/16

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racFTY720 Phosphate Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Labelled rac FTY720 (F805010). rac FTY720 is a sphingosine 1-phosphate receptor modular, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration.

Definition

ChEBI: Fingolimod phosphate is a primary amino compound that is fingolimod in which one on the hydroxy groups has been converted into its dihydrogen phosphate derivative. It is the active metabolite of fingolimod. It has a role as an antineoplastic agent, an immunosuppressive agent and a sphingosine-1-phosphate receptor agonist. It is a monoalkyl phosphate, a primary amino compound and a primary alcohol. It is functionally related to a fingolimod.

Biological Activity

fty720 is sphingosine-1-phosphate (s1p) receptors agonist [1]. fty720 is a novel immunomodulatory agent derived from isp-1 (myriocin), a fungal metabolite that exists in traditional chinese herbal medicine. in higher eukaryotes, s1p is the ligand for five g-protein-coupled receptors. these s1p receptors are differentially expressed and regulate vascular maturation, angiogenesis, cardiac development and immunity. s1p receptors are important for directed cell movement [2].

in vitro

the phosphorylated fty720 acted as agonist for a family of g protein-coupled receptors in vitro. fty720 inhibited sphingosine-1-phosphate lyase activity [3]. fty720 phosphate acted as a potent agonist at sphingosine-1-phosphate (s1p) receptors s1p1, s1p3, s1p4, and s1p5 with ic50 values of 0.2-6 nm [3].

in vivo

in a variety of transplant and autoimmune models, fty720 was efficacious without inducing a generalized immunosuppressed state. fty720 was effective in human kidney transplantation. fty720 elicited lymphopenia resulting from a reversible redistribution of lymphocytes from circulation to secondary lymphoid tissues by unknown mechanisms. in a rodent model of multiple sclerosis, the phosphorylated fty720 compound was a potent agonist at four s s1p receptors. phosphorylation of fty720 acted through sphingosine 1-phosphate signaling pathways to modulate chemotactic responses and lymphocyte trafficking [1]. fty720 was phosphorylated in vivo. in mice, treatment with fty720 inhibited tissue sphingosine-1-phosphate lyase activity, whereas lyase gene and protein expression were not significantly affected [3].

References

[1] brinkmann v, davis m d, heise c e, et al. the immune modulator fty720 targets sphingosine 1-phosphate receptors[j]. journal of biological chemistry, 2002, 277(24): 21453-21457.
[2] spiegel s, milstien s. sphingosine-1-phosphate: an enigmatic signalling lipid[j]. nature reviews molecular cell biology, 2003, 4(5): 397-407.
[3] bandhuvula p, tam y y, oskouian b, et al. the immune modulator fty720 inhibits sphingosine-1-phosphate lyase activity[j]. journal of biological chemistry, 2005, 280(40): 33697-33700.

racFTY720 Phosphate Preparation Products And Raw materials

Raw materials

Preparation Products

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402615-91-2, racFTY720 PhosphateRelated Search:

(S) FTY720 PHOSPHATE 1,3-Propanediol, 2-amino-2-[2-(4-decylphenyl)ethyl]- 2-NitrodeaMino FingoliMod Heptyl Deoctyl Fingolimod Hydrochloride N-[1,1-Bis[(acetyloxy)methyl]-3-(4-octylphenyl)propyl]acetamide Fingolimod Fingolimod Fingolimod Impurity 7 N-(1-hydroxy-2-(hydroxymethyl)-4-(4-octylphenyl)butan-2-yl)acetamide 2-DiMethylaMino FingoliMod Fingolimod Fingolimod Impurity 11 3-AMino-3-(hydroxyMethyl)-1-(4-octylphenyl)-1,4-butanediol Fingolimod Fingolimod Hexyl Impurity Fingolimod Fingolimod Fingolimod Stearate Amide

2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol 1-(Dihydrogen Phosphate)

2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol Mono(dihydrogen phosphate) Ester

FTY720 Phosphate

2-AMino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol-d4 1-(Dihydrogen Phosphate)

2-AMino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol-d4 Mono(dihydrogen phosphate) Ester

FTY720-P-d4

FTY-P-d4

rac FTY720-d4 Phosphate

FingoliMod phosphate

FingoliMod phosphate D4

FTY720-P

FTY-P

racFTY720 Phosphate

2-AMino-2-(HydroxyMethyl)-4-(4-Octylphenyl)Butyl Dihydrogen Phosphate

Fingolimod Impurity 12(Fingolimod Phosphate)

Fingolimod Impurity 12

Fingolimod phosphateQ: What is Fingolimod phosphate Q: What is the CAS Number of Fingolimod phosphate Q: What is the storage condition of Fingolimod phosphate Q: What are the applications of Fingolimod phosphate

2-AMino-2-[2-(4-Chemicalbookoctylphenyl)ethyl]-1,3-propanediol-d41-(DihydrogenPhosphate)

1,3-Propanediol, 2-amino-2-[2-(4-octylphenyl)ethyl]-, 1-(dihydrogen phosphate)

acFTY720 Phosphate

2-Amino-2- (hydroxymethyl) -4- (4-octylphenyl) butyl dihydrogen phosphate ester

402615-91-2

C19H34NO5P

Aromatics Compounds

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals

Phosphorylating and Phosphitylating Agents

Isotope Labelled Compounds