3-[(4-bromophenyl)amino]propanoic acid
- Product Name
- 3-[(4-bromophenyl)amino]propanoic acid
- CAS No.
- 90561-83-4
- Chemical Name
- 3-[(4-bromophenyl)amino]propanoic acid
- Synonyms
- OTAVA-BB 1142586;UKRORGSYN-BB BBV-215965;N-(4-BROMOPHENYL)-B-ALANINE;β-Alanine, N-(4-bromophenyl)-;B-ALANINE, N-(4-BROMOPHENYL)-;3-[(4-bromophenyl)amino]propanoic acid
- CBNumber
- CB81710698
- Molecular Formula
- C9H10BrNO2
- Formula Weight
- 244.09
- MOL File
- 90561-83-4.mol
3-[(4-bromophenyl)amino]propanoic acid Property
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 127050
- Product name
- 3-((4-Bromophenyl)amino)propanoicacid
- Purity
- >95%
- Packaging
- 1g
- Price
- $684
- Updated
- 2021/12/16
- Product number
- 4076CX
- Product name
- 3-((4-Bromophenyl)amino)propanoicacid
- Packaging
- 5g
- Price
- $793
- Updated
- 2021/12/16
- Product number
- HCH0358068
- Product name
- 3-(4-BROMOPHENYLAMINO)PROPANOIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.42
- Updated
- 2021/12/16
- Product number
- A162062
- Product name
- 3-((4-Bromophenyl)amino)propanoicacid
- Purity
- 95+%
- Packaging
- 5g
- Price
- $543
- Updated
- 2021/12/16
- Product number
- A-3606
- Product name
- N-(4-Bromophenyl)-b-alanine
- Purity
- 97%
- Packaging
- 5g
- Price
- $825
- Updated
- 2021/12/16
3-[(4-bromophenyl)amino]propanoic acid Chemical Properties,Usage,Production
Synthesis
79-10-7
106-40-1
90561-83-4
a) 4-Bromoaniline (2.0 g, 11.6 mmol) and acrylic acid (0.95 mL, 13.9 mmol) were reacted in toluene (15 mL) with stirring at 100 °C for 3 days. After completion of the reaction, it was cooled to room temperature and extracted with 1N NaOH solution (150 mL). The aqueous phase was adjusted to pH ~3 with 2N HCl and subsequently extracted with ethyl acetate (2 x 100 mL). The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give N-(4-bromophenyl)-3-aminopropionic acid (1.65 g, 58%). b) The above carboxylic acid product (1.64 g, 6.72 mmol) was dissolved in polyphosphoric acid (30 g) and the reaction was stirred at 90 °C overnight. After completion of the reaction, it was cooled to room temperature and the reaction was quenched by the addition of ice water. The mixture was extracted with ethyl acetate (2 x 200 mL). The organic phases were combined and washed sequentially with 1N NaOH, water and saturated saline. After drying with anhydrous sodium sulfate, it was concentrated under reduced pressure to give the cyclized product (0.88 g, 58%). 1H NMR (CDCl3) δ (ppm): 2.67 (t, 2H), 3.54 (t, 2H), 6.57 (d, 1H), 7.33 (dd, 1H), 7.92 (s, 1H).
References
[1] Patent: WO2009/39553, 2009, A1. Location in patent: Page/Page column 93
[2] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 9, p. 2801 - 2807
3-[(4-bromophenyl)amino]propanoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
3-[(4-bromophenyl)amino]propanoic acid Suppliers
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- Country
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