METHYL 2-AMINO-5-BROMO-3-METHYLBENZENECARBOXYLATE
- Product Name
- METHYL 2-AMINO-5-BROMO-3-METHYLBENZENECARBOXYLATE
- CAS No.
- 206548-14-3
- Chemical Name
- METHYL 2-AMINO-5-BROMO-3-METHYLBENZENECARBOXYLATE
- Synonyms
- Methyl 2-amino-5-bromo-3-methylbenzoate;METHYL 2-AMINO-5-BROMO-3-METHYLBENZENECARBOXYLATE;2-Amino-5-bromo-3-methylbenzoic acid methyl ester;Benzoic acid, 2-aMino-5-broMo-3-Methyl-, Methyl ester;Methyl 2-amino-5-bromo-m-toluate, Methyl 5-bromo-3-methylanthranilate
- CBNumber
- CB8174024
- Molecular Formula
- C9H10BrNO2
- Formula Weight
- 244.09
- MOL File
- Mol file
METHYL 2-AMINO-5-BROMO-3-METHYLBENZENECARBOXYLATE Property
- Melting point:
- 56-58
- Boiling point:
- 307.3±37.0 °C(Predicted)
- Density
- 1.506
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 1.61±0.10(Predicted)
- Appearance
- Light yellow to brown Solid
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2933399990
N-Bromosuccinimide Price
- Product number
- OR9818
- Product name
- Methyl2-amino-5-bromo-3-methylbenzoate
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- OR9818
- Product name
- Methyl2-amino-5-bromo-3-methylbenzoate
- Packaging
- 5g
- Price
- $211
- Updated
- 2021/12/16
- Product number
- 4758-9-03
- Product name
- Methyl 2-amino-5-bromo-3-methylbenzenecarboxylate
- Packaging
- 1g
- Price
- $256
- Updated
- 2021/12/16
- Product number
- CS-0035707
- Product name
- Methyl2-amino-5-bromo-3-methylbenzoate
- Packaging
- 5g
- Price
- $306
- Updated
- 2021/12/16
- Product number
- 6996AD
- Product name
- Methyl2-amino-5-bromo-3-methylbenzenecarboxylate
- Packaging
- 5g
- Price
- $321
- Updated
- 2021/12/16
METHYL 2-AMINO-5-BROMO-3-METHYLBENZENECARBOXYLATE Chemical Properties,Usage,Production
Synthesis
22223-49-0
206548-14-3
General procedure for the synthesis of methyl 2-amino-5-bromo-3-methylbenzoate from methyl 2-amino-3-methylbenzoate: Methyl 2-amino-3-methylbenzoate (142.1 g, 0.843 mol, purity: 98%, quantitative NMR) was dissolved in 240 mL of water, and hydrogen bromide (48% aqueous solution, 149.2 g, 0.885 mol). Subsequently, the resulting suspension was mixed with hydrogen peroxide (30% aqueous solution, 105.1 g, 0.927 mol), and the acceleration of the drop was controlled so that the reaction was completed within 2 h and the reaction temperature was kept lower than 70°C. The reaction mixture was continued to be stirred for 1 h. After the reaction mixture had continued to be stirred for 1 h, sodium bisulphite (39% aqueous solution, 33.7 g, 0.126 mol) was added in batches until the test for peroxide was negative . The pH of the reaction mixture was adjusted to 7-8 with sodium carbonate (0.1 equiv, 9.0 g, 0.084 mol) in batches. after filtration and vacuum drying, methyl 2-amino-5-bromo-3-methylbenzoate was obtained as a light brown solid. Yield: 204.2 g, yield: 97.7%, purity: 98.5% (quantitative NMR).1H NMR (600 MHz, d6-DMSO): δ= 7.70 (d, 1H), 7.36 (pt, 1H), 6.63 (br s, 2H), 3.80 (s, 3H), 2.12 (s, 3H).
References
[1] Patent: US2014/148611, 2014, A1. Location in patent: Paragraph 0066; 0067; 0068
[2] Helvetica Chimica Acta, 2004, vol. 87, # 6, p. 1333 - 1356
[3] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 3, p. 1156 - 1162
[4] Patent: US2015/111870, 2015, A1. Location in patent: Paragraph 0687; 0688
[5] Patent: WO2018/49328, 2018, A1. Location in patent: Page/Page column 26; 27; 28
METHYL 2-AMINO-5-BROMO-3-METHYLBENZENECARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
METHYL 2-AMINO-5-BROMO-3-METHYLBENZENECARBOXYLATE Suppliers
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View Lastest Price from METHYL 2-AMINO-5-BROMO-3-METHYLBENZENECARBOXYLATE manufacturers
- Product
- methyl 5-bromo-1H-indazole-7-carboxylate 206548-14-3
- Price
- US $0.00/kg
- Min. Order
- 20kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2025-04-30
- Product
- METHYL 2-AMINO-5-BROMO-3-METHYLBENZENECARBOXYLATE 206548-14-3
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-14