ChemicalBook > CAS DataBase List > 2-chloro-5H-pyrrolo[2,3-b]pyrazine
2-chloro-5H-pyrrolo[2,3-b]pyrazine
Uses- Product Name
- 2-chloro-5H-pyrrolo[2,3-b]pyrazine
- CAS No.
- 889447-19-2
- Chemical Name
- 2-chloro-5H-pyrrolo[2,3-b]pyrazine
- Synonyms
- 2-chloro-5H-pyrrolo[2;2-Chloro-5H-pyrrolo[2,3-b...;2-chloro-5H-pyrrolo[2,3-b]pyrazine;2-chloro-5H-pyrrolo[3,2-b]pyrazine;5H-Pyrrolo[2,3-b]pyrazine, 2-chloro-
- CBNumber
- CB81856095
- Molecular Formula
- C6H4ClN3
- Formula Weight
- 153.57
- MOL File
- 889447-19-2.mol
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2-chloro-5H-pyrrolo[2,3-b]pyrazine Property
- Density
- 1.531±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 10.63±0.50(Predicted)
- Appearance
- yellow solid
- InChI
- InChI=1S/C6H4ClN3/c7-5-3-9-6-4(10-5)1-2-8-6/h1-3H,(H,8,9)
- InChIKey
- RORAIVYFQFAIAF-UHFFFAOYSA-N
- SMILES
- C12NC=CC1=NC(Cl)=CN=2
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Safety
- HS Code
- 2933998090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- C384408
- Product name
- 2-Chloro-5H-pyrrolo[2,3-B]pyrazine
- Packaging
- 100mg
- Price
- $130
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FC144247
- Product name
- 2-Chloro-5H-pyrrolo[2,3-b]pyrazine
- Packaging
- 10mg
- Price
- $50
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FC144247
- Product name
- 2-Chloro-5H-pyrrolo[2,3-b]pyrazine
- Packaging
- 25mg
- Price
- $100
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FC144247
- Product name
- 2-Chloro-5H-pyrrolo[2,3-b]pyrazine
- Packaging
- 50mg
- Price
- $150
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 3H32-5-C5
- Product name
- 2-Chloro-5H-pyrrolo[2,3-b]pyrazine
- Packaging
- 250mg
- Price
- $225
- Updated
- 2021/12/16
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2-chloro-5H-pyrrolo[2,3-b]pyrazine Chemical Properties,Usage,Production
Uses
2-Chloro-5H-pyrrolo[2,3-B]pyrazine is a common pyrrolo[2,3-B]pyrazine bicyclic compound, widely used in the preparation of pharmaceutical and chemical intermediates.
Synthesis
875781-43-4
889447-19-2
General procedure for the synthesis of 2-chloro-5H-pyrrolo[2,3-b]pyrazine from 5-bromo-4,7-diazaindole: 2-bromo-5H-pyrrolo[2,3-b]pyrazine (3.1 g, 16 mmol) was dissolved in 1,4-dioxane (20 mL), and phosphorochloridic acid (2.27 mL, 24.1 mmol) was added. Subsequently, triethylamine (220 μL, 1.58 mmol) was added and the reaction was carried out at 110 °C for 6 hours. After completion of the reaction, the reaction mixture was dried with anhydrous sodium sulfate and concentrated. Purification by column chromatography (petroleum ether/ethyl acetate, v/v=2/1) gave 1.3 g of gray solid product in 54% yield.
References
[1] Patent: CN106336413, 2017, A. Location in patent: Paragraph 0379; 0380; 0381
2-chloro-5H-pyrrolo[2,3-b]pyrazine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-chloro-5H-pyrrolo[2,3-b]pyrazine manufacturers
Career Henan Chemical Co
- Product
- 2-chloro-5H-pyrrolo[2,3-b]pyrazine 889447-19-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-03