4-chloro-2-(trifluoromethyl)thieno[3,2-d]pyrimidine

Product Name: 4-chloro-2-(trifluoromethyl)thieno[3,2-d]pyrimidine
CAS No.: 147972-27-8
Chemical Name: 4-chloro-2-(trifluoromethyl)thieno[3,2-d]pyrimidine
Synonyms: 4-chloro-2-(trifluoromethyl)thieno[3,2-d]pyrimidine;Thieno[3,2-d]pyrimidine, 4-chloro-2-(trifluoromethyl)-;4-chloro-2-(trifluoromethyl)thieno[3,2-d]pyrimidine ISO 9001：2015 REACH
CBNumber: CB81856121
Molecular Formula: C7H2ClF3N2S
Formula Weight: 238.62
MOL File: 147972-27-8.mol

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4-chloro-2-(trifluoromethyl)thieno[3,2-d]pyrimidine Property

Boiling point:: 165.5±40.0 °C(Predicted)
Density: 1.646±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -1.33±0.40(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B421143
Product name: 4-chloro-2-(trifluoromethyl)thieno[3,2-d]pyrimidine
Packaging: 100mg
Price: $110
Updated: 2021/12/16

AK Scientific

Product number: W3230
Product name: 4-Chloro-2-(trifluoromethyl)thieno[3,2-d]pyrimidine
Packaging: 100mg
Price: $151
Updated: 2021/12/16

Matrix Scientific

Product number: 073177
Product name: 4-Chloro-2-(trifluoromethyl)-thieno[3,2-d]pyrimidine
Purity: 95+%
Packaging: 250mg
Price: $537
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0062607
Product name: 4-CHLORO-2-(TRIFLUOROMETHYL)THIENO[3,2-D]PYRIMIDINE
Purity: 95.00%
Packaging: 1G
Price: $1143.61
Updated: 2021/12/16

Matrix Scientific

Product number: 073177
Product name: 4-Chloro-2-(trifluoromethyl)-thieno[3,2-d]pyrimidine
Purity: 95+%
Packaging: 1g
Price: $1158
Updated: 2021/12/16

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4-chloro-2-(trifluoromethyl)thieno[3,2-d]pyrimidine Chemical Properties,Usage,Production

Synthesis

147972-26-7

147972-27-8

1. To a stirred solution of methyl 3-aminothiophene-2-carboxylate (45a, 1.57 g, 10.0 mmol) in ethanol (EtOH, 10 mL) was sequentially added trifluoroacetamidine (2.24 g, 20.0 mmol) and trifluoroacetic acid (1.54 mL, 20.0 mmol) at 45 °C. 2. The reaction mixture was transferred to a microwave reactor, heated to 150 °C and kept for 1 hour. 3. After completion of the reaction, it was cooled to room temperature and the solid was collected by filtration to afford 2-(trifluoromethyl)thieno[3,2-d]pyrimidin-4(3H)-one (45b, 0.61 g). 4. 2-(Trifluoromethyl)thieno[3,2-d]pyrimidin-4(3H)-one (45b, 0.61 g, 2.77 mmol) was suspended in phosphorus oxychloride (POCl3) and refluxed for 3 h under nitrogen protection. 5. At the end of the reaction, POCl3 was removed by concentration under reduced pressure. 6. The residue was partitioned between ethyl acetate and saturated sodium bicarbonate (NaHCO3) solution and the organic phase was dried and concentrated to afford 4-chloro-2-trifluoromethylthieno[3,2-d]pyrimidine (45c, 0.58 g, 88% yield).

References

[1] Patent: WO2006/72831, 2006, A1. Location in patent: Page/Page column 66-67

4-chloro-2-(trifluoromethyl)thieno[3,2-d]pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-chloro-2-(trifluoromethyl)thieno[3,2-d]pyrimidine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4-chloro-2-(trifluoromethyl)thieno[3,2-d]pyrimidine 147972-27-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-26

147972-27-8, 4-chloro-2-(trifluoromethyl)thieno[3,2-d]pyrimidineRelated Search:

Oxalyl chloride TRANS-3-(TRIFLUOROMETHYL)CINNAMOYL CHLORIDE CHLOROMETHYL TRIFLUOROMETHYL SULFIDE 2,5-di(chloromethyl)thiophene Thieno[3,2-d]pyrimidine, 4-chloro-2-methyl- 4-chloro-2-(trifluoromethyl)thieno[3,2-d]pyrimidine

4-chloro-2-(trifluoromethyl)thieno[3,2-d]pyrimidine

Thieno[3,2-d]pyrimidine, 4-chloro-2-(trifluoromethyl)-

4-chloro-2-(trifluoromethyl)thieno[3,2-d]pyrimidine ISO 9001：2015 REACH

147972-27-8

C7H2ClF3N2S

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Fluorine series