Benzonitrile, 2-amino-3-hydroxy-
- Product Name
- Benzonitrile, 2-amino-3-hydroxy-
- CAS No.
- 211172-52-0
- Chemical Name
- Benzonitrile, 2-amino-3-hydroxy-
- Synonyms
- 2-AMino-3-hydroxy-benzonitrile;Benzonitrile, 2-amino-3-hydroxy-
- CBNumber
- CB81872013
- Molecular Formula
- C7H6N2O
- Formula Weight
- 134.14
- MOL File
- 211172-52-0.mol
Benzonitrile, 2-amino-3-hydroxy- Property
- Boiling point:
- 301.5±37.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 8.37±0.10(Predicted)
- Appearance
- Light brown to brown Solid
Safety
- RIDADR
- UN3439
- HazardClass
- 6.1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A636198
- Product name
- 2-Amino-3-hydroxybenzonitrile
- Packaging
- 50mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- A636198
- Product name
- 2-Amino-3-hydroxybenzonitrile
- Packaging
- 100mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- 244064
- Product name
- 2-Amino-3-hydroxybenzonitrile
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- CHM0387977
- Product name
- 2-AMINO-3-HYDROXYBENZONITRILE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.59
- Updated
- 2021/12/16
- Product number
- 0783AB
- Product name
- 2-Amino-3-hydroxybenzonitrile
- Packaging
- 1g
- Price
- $984
- Updated
- 2021/12/16
Benzonitrile, 2-amino-3-hydroxy- Chemical Properties,Usage,Production
Synthesis
129298-23-3
211172-52-0
B. 3-Hydroxy-2-nitrobenzonitrile (1.31 g) was mixed with 10% Pd/C (131 mg) in a solvent mixture of ethanol (9 mL) and ethyl acetate (18 mL), and the reaction was stirred overnight under hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by filtration through diatomaceous earth and the filtrate was subsequently concentrated. The resulting residue was purified by column chromatography (eluent: hexane/ethyl acetate, 6/4) to give 2-amino-3-hydroxybenzonitrile (398 mg, 37% yield).
References
[1] Journal of Medicinal Chemistry, 2004, vol. 47, # 6, p. 1319 - 1321
[2] Patent: WO2008/110793, 2008, A1. Location in patent: Page/Page column 106-107
[3] Patent: US5840764, 1998, A
[4] Patent: WO2011/106986, 2011, A1. Location in patent: Page/Page column 122; 123
Benzonitrile, 2-amino-3-hydroxy- Preparation Products And Raw materials
Raw materials
Preparation Products
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