ChemicalBook > CAS DataBase List > Calcitriol-d6

Calcitriol-d6

Product Name
Calcitriol-d6
CAS No.
78782-99-7
Chemical Name
Calcitriol-d6
Synonyms
Silkis-d6;Calcijex-d6;Soltriol-d6;Toptriol-d6;Panbonis-d6;Topitriol-d6;Rocaltrol-d6;Solbone P-d6;Ro 21-5535-d6;Calcitriol-d6
CBNumber
CB81872987
Molecular Formula
C27H38D6O3
Formula Weight
423
MOL File
78782-99-7.mol
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Calcitriol-d6 Property

Melting point:
77-79°C
Flash point:
14℃
storage temp. 
-20°C
solubility 
Soluble in Chloroform
form 
Powder
color 
White to off-white
Stability:
Light and temperature sensitive
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Safety

RIDADR 
UN1170 - class 3 - PG 2 - Ethanol, solution
HS Code 
9999999999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
809926
Product name
1α,25-Dihydroxyvitamin D3-26,26,26,27,27,27-d6 solution
Purity
100 μg/mL in ethanol, ≥98 atom % D, ≥95% (CP)
Packaging
1ml
Price
$1488
Updated
2025/07/31
Cayman Chemical
Product number
22179
Product name
Calcitriol-d6
Purity
≥99% deuterated forms (d1-d6)
Packaging
500μg
Price
$480
Updated
2024/03/01
Cayman Chemical
Product number
22179
Product name
Calcitriol-d6
Purity
≥99% deuterated forms (d1-d6)
Packaging
1mg
Price
$912
Updated
2024/03/01
Usbiological
Product number
005513
Product name
Calcitriol-d6
Packaging
500ug
Price
$602
Updated
2021/12/16
TRC
Product number
C144502
Product name
Calcitriol-d6
Packaging
0.5mg
Price
$295
Updated
2021/12/16
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Calcitriol-d6 Chemical Properties,Usage,Production

Description

Calcitriol-d6 is intended for us as an internal standard for the quantification of calcitriol by GC- or LC-MS. Calcitriol is synthesized from 7-dehydro cholesterol in humans via a non-enzymatic photochemical reaction with 290-310 nm UV light in the skin. Hydroxylation of the resulting cholecalciferol in the liver produces 25-hydroxy vitamin D3, the principal circulating form of vitamin D. A second, tightly regulated hydroxylation in the kidney produces calcitriol. Plasma calcitriol levels range from 10-70 pg/ml and are influenced by numerous dietary and hormonal factors. The main physiologic effects of calcitriol are to increase the absorption of calcium at the level of the intestinal epithelium, and to increase the mineralization of bone via the direct stimulation of osteoblasts.

Chemical Properties

Off-White to Pale Yellow Solid

Uses

The biologically active form of vitamin D3. Calcium regulator; vitamin (antirachitic); antihyperparathyroid; antineoplastic; antipsoriatic

Uses

1α,25-Dihydroxyvitamin D3-26,26,26,27,27,27-d6?can be used as an analytical standard for the quantitative analysis of dihydroxyvitamin D3?concentration in human serum via LC-MS.

General Description

1α,25-Dihydroxyvitamin D3?[1,25(OH)2D3], also known as calcitriol, plays a role in calcium and phosphate metabolism in humans. It also regulates insulin secretion and induces cellular differentiation.
1α,25-Dihydroxyvitamin D3-26,26,26,27,27,27-d6?is a deuterated vitamin D3 wherein C-26 and C-27 carbon methyl protons are replaced by deuterium.

References

[1] D. E. M. LAWSON. Identification of 1,25-Dihydroxycholecalciferol, a New Kidney Hormone controlling Calcium Metabolism[J]. Nature, 1971, 230 5291: 228-230. DOI: 10.1038/230228a0
[2] M R HAUSSLER. Biological activity of 1alpha-hydroxycholecalciferol, a synthetic analog of the hormonal form of vitamin D3.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1973, 70 8: 2248-2252. DOI: 10.1073/pnas.70.8.2248
[3] L. BINDERUP . 20-EPI-vitamin D3 analogues: A novel class of potent regulators of cell growth and immune responses[J]. Biochemical pharmacology, 1991, 42 8: Pages 1569-1575. DOI: 10.1016/0006-2952(91)90426-6
[4] ANTONIO CANALEJO. The in vitro effect of calcitriol on parathyroid cell proliferation and apoptosis.[J]. Journal of The American Society of Nephrology, 2000, 11 10: 1865-1872. DOI: 10.1681/asn.v11101865

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Raw materials

Preparation Products

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View Lastest Price from Calcitriol-d6 manufacturers

Career Henan Chemical Co
Product
Calcitriol-d6 78782-99-7
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
JD 807
Release date
2019-09-02

78782-99-7, Calcitriol-d6Related Search:


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  • 78782-99-7
  • C27H38D6O3
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