(R)-6,7-dimethoxy-4-(3-(quinoxalin-2-yloxy)pyrrolidin-1-yl)quinazoline
- Product Name
- (R)-6,7-dimethoxy-4-(3-(quinoxalin-2-yloxy)pyrrolidin-1-yl)quinazoline
- CAS No.
- 927691-21-2
- Chemical Name
- (R)-6,7-dimethoxy-4-(3-(quinoxalin-2-yloxy)pyrrolidin-1-yl)quinazoline
- Synonyms
- A844337;A-844337;A 844337;PQ-10, 10 mM in DMSO;6,7-dimethoxy-4-[3-(2-quinoxalinyloxy)-1-pyrrolidinyl]quinazoline;6,7-dimethoxy-4-[(3R)-3-quinoxalin-2-yloxypyrrolidin-1-yl]quinazoline;6,7-Dimethoxy-4-[(3R)-3-(2-quinoxalinyloxy)-1-pyrrolidinyl]quinazoline;(R)-6,7-dimethoxy-4-(3-(quinoxalin-2-yloxy)pyrrolidin-1-yl)quinazoline;Quinazoline, 6,7-dimethoxy-4-[(3R)-3-(2-quinoxalinyloxy)-1-pyrrolidinyl]-;inhibit,Phosphodiesterase (PDE),PQ-10,Phosphodiesterase 10A,translational biomarker,schizophrenia,PQ10,PDE10A,glucose metabolism,Inhibitor,psychiatric disorders
- CBNumber
- CB81876389
- Molecular Formula
- C22H21N5O3
- Formula Weight
- 403.43
- MOL File
- 927691-21-2.mol
(R)-6,7-dimethoxy-4-(3-(quinoxalin-2-yloxy)pyrrolidin-1-yl)quinazoline Property
- Density
- 1.333
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble10mg/mL, clear
- form
- powder
- color
- white to beige
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML1116
- Product name
- PQ-10
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $332
- Updated
- 2025/07/31
- Product number
- SML1116
- Product name
- PQ-10
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $107
- Updated
- 2022/05/15
- Product number
- 21867
- Product name
- PQ-10
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $43
- Updated
- 2024/03/01
- Product number
- 21867
- Product name
- PQ-10
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $106
- Updated
- 2024/03/01
- Product number
- 21867
- Product name
- PQ-10
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $187
- Updated
- 2024/03/01
(R)-6,7-dimethoxy-4-(3-(quinoxalin-2-yloxy)pyrrolidin-1-yl)quinazoline Chemical Properties,Usage,Production
Description
PQ-10 is a potent and selective inhibitor of phosphodiesterase type 10 (PDE10; Ki = 4 nM). It has >38-fold selectivity for PDE10 over a panel of 60 CNS-associated receptors, enzymes, and ion channels in vitro. Subcutaneous injection of PQ-10 (32 mg/kg) leads to increases in striatal cGMP and phosphorylation of cAMP response element binding protein (CREB) in murine striatum, known markers of in vivo PDE10 inhibition. PQ-10 at a dose of 0.3 mg/kg, p.o., reduces scopolamine- and MK-801-induced memory deficits in rats. PQ-10 also inhibits tumor cell growth with IC50 values of 0.29 and 0.22 mM for HCT116 and SW480 colon cancer cells, respectively.
Uses
PQ-10 is a potent inhibitor of Phosphodiesterase 10A (PDE10A) with IC50 andED50 of 4.6 nM and 13 mg/kg, respectively. PQ-10 induces patterns of brain glucose metabolism which can be a potential translational biomarker. PQ-10 has the potential for researching psychiatric disorders like schizophrenia[1].
Biochem/physiol Actions
PQ-10 is a potent and selective inhibitor of phosphodiesterase 10A (PDE10). Apparently, PQ-10 enhances basic auditory information processing in rats. PQ-10 as other PED10 inhibitors suppresses a growth of human non-small cell lung cancer (NSCLC) cell lines.
in vivo
PQ-10 shows region-specific increases in 2-DG uptake in the globus pallidus (equivalent to the external segment of the globus pallidus in primates) and the lateral habenula in mice[1].
| Animal Model: | 24 –28 g male C57BL/6 mice, PDE10A WT and KO mice[1] |
| Dosage: | 0.16, 0.63, 2.5, and 10 mg/kg |
| Administration: | s.c. |
| Result: | Showed region-specific increases in 2-DG uptake in the globus pallidus (equivalent to the external segment of the globus pallidus in primates) and the lateral habenula in mice. |
IC 50
PDE10A: 4.6 nM (IC50)
References
[1] Dedeurwaerdere S, et al. Patterns of brain glucose metabolism induced by phosphodiesterase 10A inhibitors in the mouse: a potential translational biomarker. J Pharmacol Exp Ther. 2011;339(1):210-217. DOI:10.1124/jpet.111.182766
(R)-6,7-dimethoxy-4-(3-(quinoxalin-2-yloxy)pyrrolidin-1-yl)quinazoline Preparation Products And Raw materials
Raw materials
Preparation Products
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