ETHYL 2-AMINOINDOLE-3-CARBOXYLATE
- Product Name
- ETHYL 2-AMINOINDOLE-3-CARBOXYLATE
- CAS No.
- 6433-72-3
- Chemical Name
- ETHYL 2-AMINOINDOLE-3-CARBOXYLATE
- Synonyms
- 2-amino-, ethyl ester;ETHYL 2-AMINOINDOLE-3-CARBOXYLATE;ethyl 2-aminoindoline-3-carboxylate;2-AMINOINDOLE-3-CARBOXYLIC ETHYL ESTER;ETHYL 2-AMINOINDOLE-3-CARBOXYLATE USP/EP/BP;2-AMINOINDOLE-3-CARBOXYLIC ACID, ETHYL ESTER;1H-Indole-3-carboxylicacid, 2-amino-, ethyl ester;1H-Indole-3-carboxylicacid,2-amino-,ethylester(9CI);2-amino-2,3-dihydro-1H-indole-3-carboxylic acid ethyl ester
- CBNumber
- CB8189183
- Molecular Formula
- C11H12N2O2
- Formula Weight
- 204.23
- MOL File
- 6433-72-3.mol
ETHYL 2-AMINOINDOLE-3-CARBOXYLATE Property
- Melting point:
- 178-180°C
- Boiling point:
- 400.1±25.0 °C(Predicted)
- Density
- 1.288±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- Benzene, DMSO, Methanol
- form
- Solid
- pka
- 17.31±0.30(Predicted)
- color
- Off-White to Brown
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- E898525
- Product name
- Ethyl2-Aminoindole-3-carboxylate
- Packaging
- 1g
- Price
- $220
- Updated
- 2021/12/16
- Product number
- CS-0037019
- Product name
- Ethyl2-amino-1H-indole-3-carboxylate
- Purity
- ≥97.0%
- Packaging
- 100mg
- Price
- $57
- Updated
- 2021/12/16
- Product number
- CS-0037019
- Product name
- Ethyl2-amino-1H-indole-3-carboxylate
- Purity
- ≥97.0%
- Packaging
- 250mg
- Price
- $82
- Updated
- 2021/12/16
- Product number
- CS-0037019
- Product name
- Ethyl2-amino-1H-indole-3-carboxylate
- Purity
- ≥97.0%
- Packaging
- 1g
- Price
- $205
- Updated
- 2021/12/16
- Product number
- CHM0014326
- Product name
- ETHYL 2-AMINOINDOLE-3-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $721.88
- Updated
- 2021/12/16
ETHYL 2-AMINOINDOLE-3-CARBOXYLATE Chemical Properties,Usage,Production
Chemical Properties
Off-White Crystalline Solid
Uses
Ethyl 2-Aminoindole-3-carboxylate (cas# 6433-72-3) is a compound useful in organic synthesis.
Synthesis
65548-02-9
6433-72-3
Step 2. Synthesis of ethyl 2-amino-1H-indole-3-carboxylate [Formula 12-3]: Ethyl 2-cyano-2-(2-nitrophenyl)acetate [Formula 12-2] (16 g, 68.315 mmol) was dissolved in acetic acid (200 mL), and zinc powder (17.86 g, 273.25 mmol) was added, and the reaction was stirred for 24 hr at 65 °C. Upon completion of the reaction, the zinc powder was removed by diatomaceous earth filtration and the acetic acid was removed by distillation under reduced pressure to give a solid product. The resulting solid was dissolved in excess dichloromethane and subsequently crystallized by addition of hexane to give ethyl 2-aminoindole-3-carboxylate (6 g, 44% yield).
References
[1] Chinese Journal of Chemistry, 2013, vol. 31, # 2, p. 263 - 266
[2] Patent: WO2013/62344, 2013, A1. Location in patent: Page/Page column 28; 99
[3] Patent: US2014/315889, 2014, A1. Location in patent: Paragraph 0472-0474
[4] Tetrahedron Letters, 2006, vol. 47, # 2, p. 159 - 162
[5] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 20, p. 6123 - 6133,11
ETHYL 2-AMINOINDOLE-3-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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