ChemicalBook > CAS DataBase List > A[5']P5[5']A SODIUM SALT

A[5']P5[5']A SODIUM SALT

Product Name
A[5']P5[5']A SODIUM SALT
CAS No.
4097-04-5
Chemical Name
A[5']P5[5']A SODIUM SALT
Synonyms
A(5′)P5(5′)A;A[5']P5[5']A SODIUM SALT;DIADENOSINE PENTAPHOSPHATE SODIUM SALT;Diadenosine pentaphosphate pentasodium;5'-ester with adenosine pentasodium salt;P1,P5-Di(adenosine-5;Diadenosine pentaphosphate pentasodium salt;P1,P5-DI(ADENOSINE-5') PENTAPHOSPHATESOD IUM;P1,P5-DI(ADENOSINE-5') PENTAPHOSPHATE SODIUM SALT;P1,P5-di(adenosine-5')pentaphosphate pentasodium salt 5H2O
CBNumber
CB8189688
Molecular Formula
C20H24N10Na5O22P5
Formula Weight
1026.28
MOL File
4097-04-5.mol
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A[5']P5[5']A SODIUM SALT Property

storage temp. 
-20°C
solubility 
H2O: 50 mg/mL
form 
powder
color 
white to white with yellow cast
BRN 
4949216
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Safety

WGK Germany 
3
F 
10-21
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D4022
Product name
P1,P5-Di(adenosine-5′) pentaphosphate pentasodium salt
Purity
≥95% (HPLC), powder
Packaging
2MG
Price
$64.2
Updated
2023/06/20
Sigma-Aldrich
Product number
D4022
Product name
P1,P5-Di(adenosine-5′) pentaphosphate pentasodium salt
Purity
≥95% (HPLC), powder
Packaging
10MG
Price
$158
Updated
2023/06/20
Sigma-Aldrich
Product number
D4022
Product name
P1,P5-Di(adenosine-5′) pentaphosphate pentasodium salt
Purity
≥95% (HPLC), powder
Packaging
25MG
Price
$310
Updated
2023/06/20
Sigma-Aldrich
Product number
D4022
Product name
P1,P5-Di(adenosine-5′) pentaphosphate pentasodium salt
Purity
≥95% (HPLC), powder
Packaging
50MG
Price
$557
Updated
2023/06/20
Usbiological
Product number
296060
Product name
Diadenosine pentaphosphate pentasodium salt
Packaging
2mg
Price
$347
Updated
2021/12/16
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A[5']P5[5']A SODIUM SALT Chemical Properties,Usage,Production

Uses

P1,P5-Di(adenosine-5′) pentaphosphate pentasodium salt has been used as:

  • an adenylate kinase (AK) inhibitor in: sarcoma osteogenic (Saos-2) cells
  • mitochondrial lysates during ATP synthesis
  • tetramethylrhodamine methyl ester (TMRM) based membrane potential assay
  • chromoplasts

General Description

P1,P5-Di(adenosine-5′) pentaphosphate (Ap5A) is a diadenosine polyphosphate, which has a tail-to-tail dimer structure. Ap5A is synthesized in a twostep process involving the formation of adenosine 5′-tetraphosphate (P4A) from the ATP and trimeta-phosphate (P3). In the second step, P4A is converted to Ap5A. The synthesis of Ap5A requires a pH optimum in the range of 7.5 to 8.5 and is modulated by metal ions.

Biochem/physiol Actions

A diadenosine polyphosphate stored in secretory granules of thrombocytes, chromaffin and neuronal cells. After release into the extracellular space, it affects a variety of biological activities in a wide range of target tissues. In the nervous system it acts through various purinergic receptors. It also activates 5′-nucleotidase and inhibits adenosine kinase activity in vitro. Ap5A is metabolized by soluble enzymes in the blood plasma and by membrane-bound ectoenzymes of a number of cell types including endothelial and smooth muscle cells. In cardiac muscle, pM to nM concentrations significantly increase the open-probability of ryanodine-receptor (RyR2) gates, with prolonged action due to slow dissociation from the receptor.

A[5']P5[5']A SODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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A[5']P5[5']A SODIUM SALT Suppliers

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4097-04-5, A[5']P5[5']A SODIUM SALTRelated Search:

Propylamine 4-PIPERIDINOL, PROPIONATE, HYDROCHLORIDE

  • A[5']P5[5']A SODIUM SALT
  • P1,P5-DI(ADENOSINE-5') PENTAPHOSPHATE SODIUM SALT
  • Adenosine 5'-(hexahydrogen pentaphosphate), 5'->5'-ester with adenosine, pentasodium salt
  • P1,P5-DI(ADENOSINE-5') PENTAPHOSPHATESOD IUM
  • P1,P5-di(adenosine-5')pentaphosphate pentasodium salt 5H2O
  • Adenosine-5'-pentaphosphateε-5'-adenosyl α,β,γ,δ,ε-pentasodium salt
  • A(5′)P5(5′)A
  • Diadenosine pentaphosphate pentasodium salt
  • P<sup>1</sup>,P<sup>5</sup>-Di(adenosine-5′) pentaphosphate pentasodium
  • 5'-ester with adenosine pentasodium salt
  • P<sup>1</sup>,P<sup>5</sup>-Di(adenosine-5
  • P<sup>1</sup>,P<sup>5</sup>-Di(adenosine-5') pentaphosphate pentasodium salt
  • Adenosine 5'-(hexahydrogen pentaphosphate) P''''-5'-ester with adenosine pentasodium salt
  • DIADENOSINE PENTAPHOSPHATE SODIUM SALT
  • Diadenosine pentaphosphate pentasodium
  • 4097-04-5
  • C20H24N10O22P55Na
  • Substrate Analogs
  • Nucleosides, Nucleotides, Oligonucleotides
  • Nucleotide Analogs
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors
  • Enzyme Inhibitors by Type
  • Biochemicals and Reagents
  • BioChemical