Ranolazine dihydrochloride

Product Name: Ranolazine dihydrochloride
CAS No.: 95635-56-6
Chemical Name: Ranolazine dihydrochloride
Synonyms: RS 43285;RS 43285-193;RANOLAZINE HCL;Ranolazine2Hcl;Ranolazine DiHCI;azine dihydrochL;RANOLAZINE DI HCL;Ranolazine and salt;Ranolazine dihydroch;(±)-Ranolazine-d8 2HCl
CBNumber: CB8195173
Molecular Formula: C24H35Cl2N3O4
Formula Weight: 500.46
MOL File: 95635-56-6.mol

More

Less

Ranolazine dihydrochloride Property

Melting point:: 222-229.5 °C(lit.)
storage temp.: Desiccate at RT
solubility: H₂O: 10 mg/mL, soluble
form: solid
color: off-white
Water Solubility: H2O: soluble ≥10mg/mL
Merck: 14,8111
Stability:: Hygroscopic
CAS DataBase Reference: 95635-56-6(CAS DataBase Reference)

More

Less

Safety

Safety Statements: 22-24/25
WGK Germany: 3
RTECS: TK7845370
HS Code: 29335990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: R6152
Product name: Ranolazine dihydrochloride
Purity: ≥98% (HPLC), powder
Packaging: 100mg
Price: $276
Updated: 2025/07/31

Sigma-Aldrich

Product number: R6152
Product name: Ranolazine dihydrochloride
Purity: ≥98% (HPLC), powder
Packaging: 500mg
Price: $896.8
Updated: 2025/07/31

TCI Chemical

Product number: R0112
Product name: Ranolazine Dihydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $175
Updated: 2025/07/31

TCI Chemical

Product number: R0112
Product name: Ranolazine Dihydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $523
Updated: 2025/07/31

Cayman Chemical

Product number: 15604
Product name: Ranolazine (hydrochloride)
Purity: ≥98%
Packaging: 50mg
Price: $81
Updated: 2024/03/01

More

Less

Ranolazine dihydrochloride Chemical Properties,Usage,Production

Description

Ranolazine is a piperazine derivative with cardioprotective activity. It reduces the late sodium current (I_Na) in mouse myocytes expressing the long QT syndrome 3 mutant sodium channel DKPQ, ventricular myocytes isolated from a canine model of heart failure, guinea pig ventricular myocytes exposed to hydrogen peroxide or anemone toxin-II, and HEK293 cells expressing human Na_v1.5 channels (IC₅₀s = 5.9-15 μM) as well as the late potassium current (I_Kr) in canine ventricular myocytes and HEK293 cells (IC₅₀s = 11.5 and 14.4 μM, respectively). Ranolazine also inhibits radioligand binding to α₁-, β₁-, and β₂-adrenergic receptors (K_is = 8.2-19.5, 1.4-8.6, and 0.5-14.8 μM, respectively). In vivo, ranolazine (480 μg/kg per min) reduces clofilium-induced prolongation of the QTc interval and Torsade de Pointes (TdP) in rabbits. Ranolazine also reduces interstitial collagen deposition as well as atrial natriuretic peptide (ANP; Item Nos. 24539 | 24276), connective tissue growth factor (CTGF), brain natriuretic peptide (BNP; ), and matrix metalloproteinase-2 (MMP-2) mRNA levels, and prevents left ventricular dilation in a mouse model of cardiotoxicity induced by doxorubicin .

Chemical Properties

White Crystalline Powder

Uses

Ranolazine Dihydrochloride is an anti-ischemic agent which modulates myocardial metabolism. Antianginal.

Uses

treatment of angina and congestive heart failure

Biological Activity

Antianginal agent with antiarrhythmic properties that acts as a partial fatty acid oxidation inhibitor. Activates pyruvate dehydrogenase in ischemic myocytes to promote glucose oxidation, switching substrate utilization from fatty acids to glucose. Also shown to inhibit late I Na and I Kr currents.

Biochem/physiol Actions

Ranolazine is a derivative of anti-ischemic piperazine and acts as sodium (Na+)-current inhibitor. It has the potential to treat diastolic heart failure and helps in ameliorating myocardial diastolic function.

storage

Desiccate at RT

References

[1] J C SHRYOCK L B. Inhibition of late sodium current to reduce electrical and mechanical dysfunction of ischaemic myocardium[J]. British Journal of Pharmacology, 2009, 153 6: 1128-1132. DOI: 10.1038/sj.bjp.0707522
[2] RICHARD L VERRIER. Mechanisms of ranolazine’s dual protection against atrial and ventricular fibrillation.[J]. Europace, 2013, 15 3: 317-324. DOI: 10.1093/europace/eus380
[3] WEI-QUN WANG. Antitorsadogenic effects of ({+/-})-N-(2,6-dimethyl-phenyl)-(4[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazine (ranolazine) in anesthetized rabbits.[J]. Journal of Pharmacology and Experimental Therapeutics, 2008, 325 3: 875-881. DOI: 10.1124/jpet.108.137729
[4] CARLO G. TOCCHETTI. Ranolazine protects from doxorubicin-induced oxidative stress and cardiac dysfunction[J]. European Journal of Heart Failure, 2014, 16 4: 358-366. DOI: 10.1002/ejhf.50

Ranolazine dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Ranolazine dihydrochloride Suppliers

Canada 3 China 204 Europe 2 Germany 2 India 14 Japan 1 Nepal 1 Switzerland 1 United Arab Emirates 1 United Kingdom 10 United States 35 Global 274

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527621225
Email: 1791901229@qq.com
Country: China
ProdList: 6949
Advantage: 52

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14435
Advantage: 57

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 6387
Advantage: 52

Shanghai Sphchem Co., Ltd.

Tel: 021-56491756 13512199871
Fax: 021-5649-1756
Email: 2819742715@qq.com
Country: China
ProdList: 4000
Advantage: 55

More

Less

View Lastest Price from Ranolazine dihydrochloride manufacturers

Shandong Xuhuang New material CoLTD

Product: Ranolazine HCl 95635-56-6
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99.99%
Supply Ability: 200
Release date: 2025-02-21

Hebei Zhanyao Biotechnology Co. Ltd

Product: Ranolazine Dihydrochloride 95635-56-6
Price: US $10.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 99%
Supply Ability: 20 Tons
Release date: 2021-11-19

Zhuozhou Wenxi import and Export Co., Ltd

Product: Ranolazine dihydrochloride 95635-56-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-26

95635-56-6, Ranolazine dihydrochlorideRelated Search:

THIFLUZAMIDE Tenofovir Glycyrrhizic acid Zolmitriptan Capecitabine N,N-Dimethylacetamide Promethazine hydrochloride Thioacetamide CHLOROPHOSPHONAZO III Cetirizine dihydrochloride Methoxyammonium chloride Propyl gallate Chlorpromazine hydrochloride Acetamide Propyl butyrate Ranolazine Dihydrochloride Rapamycin/sirolimus

(+/-)-4-[2-HYDROXY-3-(O-METHOXYPHENOXY)PROPYL]-1-PIPERAZINEACETO-2',6'-XYLIDIDE DIHYDROCHLORIDE

n-(2,6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide dihydrochloride

(+/-)-N-(2,6-DIMETHYLPHENYL)-4-[2-HYDROXY-3-(2-METHOXYPHENOXY)PROPYL]-1-PIPERAZINEACETAMIDE DIHYDROCHLORIDE

RANOLAZINE DIHYDROCHLORIDE

RANOLAZINE HCL

Ranolazine DiHCI

Ranolazine and salt

N-(2,6-Dimethylphenyl)-2-(4-(2-hydroxy-3-(2-methoxyphenoxy)-propyl)piperazin-1-yl)acetamide di

Ranolazine (hydrochoride)

Ranolazine dihydrochloride, 98%, an anti-ischemic agent

(±)-N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide

RANOLAZINE DI HCL

Ranolazine2Hcl

Ranolazine Dihydrocloride

N-(2,6-Dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide Dihydrochloride

RS 43285

RS 43285-193

(±) -4-[2-Hydroxy-3-(o-methoxyphenoxy)propyl]-1-piperazineaceto-2μ,6μ-xylidide dihydrochloride, N-(2,6-Dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide dihydrochloride

N-(2,6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]ethanamide dihydrochloride

1-Piperazineacetamide,N-(2,6-dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-, hydrochloride(1:2)

Ranolazine dihydrochloride,(±) -4-[2-Hydroxy-3-(o-methoxyphenoxy)propyl]-1-piperazineaceto-2′,6′-xylidide dihydrochloride, N-(2,6-Dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazinea

Ranolazine dihydroch

(+/-)-1-[3-(2-Methoxyphenoxy)-2-hydroxypropyl]-4-[(2,6-diMethylphenyl)aMinocarbonylMethyl]piperazine

(±)-Ranolazine-d8 2HCl

N-(2,6-Dimethylphenyl)-2-(4-(2-hydroxy-3-(2-methoxyphenoxy)-propyl)piperazin-1-yl)acetamide dihyd

Ranolazine dihydrochloride N-(2,6-Dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl]acetamide dihydrochloride

N-(2,6-Dimethylphenyl)-2-(4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)piperazin-1-yl)acetamide dihydrochloride

N-(2,6-dimethylphenyl)-2-[4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazinyl]acetamide dihydrochloride

Ranolazine Dihydrochloride &gt

azine dihydrochL

Ranolazine dihydrochloride USP/EP/BP

Ranolazine 2HCl (RS-43285

Ranolazine dihydrochlorideQ: What is Ranolazine dihydrochloride Q: What is the CAS Number of Ranolazine dihydrochloride Q: What is the storage condition of Ranolazine dihydrochloride Q: What are the applications of Ranolazine dihydrochloride

Ranolazine dihydrochloride, Anti-ischemic agent

Ranolazine dihydrochloride, 10 mM in DMSO

95635-56-6

95635-66-6

95635-55-6

C24H33N3O42HCl

C24H35Cl2N3O4

C24H33N3O42ClH

Active Pharmaceutical Ingredients

Cardiovascular APIs

Ranolazine

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Aromatics Compounds