ChemicalBook > CAS DataBase List > Ranolazine dihydrochloride

Ranolazine dihydrochloride

Product Name
Ranolazine dihydrochloride
CAS No.
95635-56-6
Chemical Name
Ranolazine dihydrochloride
Synonyms
RS 43285;RS 43285-193;RANOLAZINE HCL;Ranolazine2Hcl;Ranolazine DiHCI;azine dihydrochL;RANOLAZINE DI HCL;Ranolazine and salt;Ranolazine dihydroch;(±)-Ranolazine-d8 2HCl
CBNumber
CB8195173
Molecular Formula
C24H35Cl2N3O4
Formula Weight
500.46
MOL File
95635-56-6.mol
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Ranolazine dihydrochloride Property

Melting point:
222-229.5 °C(lit.)
storage temp. 
Desiccate at RT
solubility 
H2O: 10 mg/mL, soluble
form 
solid
color 
off-white
Merck 
14,8111
Stability:
Hygroscopic
CAS DataBase Reference
95635-56-6(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
TK7845370
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
R6152
Product name
Ranolazine dihydrochloride
Purity
≥98% (HPLC), powder
Packaging
100mg
Price
$256
Updated
2024/03/01
Sigma-Aldrich
Product number
R6152
Product name
Ranolazine dihydrochloride
Purity
≥98% (HPLC), powder
Packaging
500mg
Price
$918
Updated
2024/03/01
TCI Chemical
Product number
R0112
Product name
Ranolazine Dihydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$194
Updated
2024/03/01
TCI Chemical
Product number
R0112
Product name
Ranolazine Dihydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$581
Updated
2024/03/01
Cayman Chemical
Product number
15604
Product name
Ranolazine (hydrochloride)
Purity
≥98%
Packaging
50mg
Price
$81
Updated
2024/03/01
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Ranolazine dihydrochloride Chemical Properties,Usage,Production

Description

Ranolazine is a piperazine derivative with cardioprotective activity. It reduces the late sodium current (INa) in mouse myocytes expressing the long QT syndrome 3 mutant sodium channel DKPQ, ventricular myocytes isolated from a canine model of heart failure, guinea pig ventricular myocytes exposed to hydrogen peroxide or anemone toxin-II, and HEK293 cells expressing human Nav1.5 channels (IC50s = 5.9-15 μM) as well as the late potassium current (IKr) in canine ventricular myocytes and HEK293 cells (IC50s = 11.5 and 14.4 μM, respectively). Ranolazine also inhibits radioligand binding to α1-, β1-, and β2-adrenergic receptors (Kis = 8.2-19.5, 1.4-8.6, and 0.5-14.8 μM, respectively). In vivo, ranolazine (480 μg/kg per min) reduces clofilium-induced prolongation of the QTc interval and Torsade de Pointes (TdP) in rabbits. Ranolazine also reduces interstitial collagen deposition as well as atrial natriuretic peptide (ANP; Item Nos. 24539 | 24276), connective tissue growth factor (CTGF), brain natriuretic peptide (BNP; ), and matrix metalloproteinase-2 (MMP-2) mRNA levels, and prevents left ventricular dilation in a mouse model of cardiotoxicity induced by doxorubicin .

Chemical Properties

White Crystalline Powder

Uses

Ranolazine Dihydrochloride is an anti-ischemic agent which modulates myocardial metabolism. Antianginal.

Uses

treatment of angina and congestive heart failure

Biological Activity

Antianginal agent with antiarrhythmic properties that acts as a partial fatty acid oxidation inhibitor. Activates pyruvate dehydrogenase in ischemic myocytes to promote glucose oxidation, switching substrate utilization from fatty acids to glucose. Also shown to inhibit late I Na and I Kr currents.

Biochem/physiol Actions

Ranolazine is a derivative of anti-ischemic piperazine and acts as sodium (Na+)-current inhibitor. It has the potential to treat diastolic heart failure and helps in ameliorating myocardial diastolic function.

storage

Desiccate at RT

Ranolazine dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ranolazine dihydrochloride manufacturers

Hebei Zhanyao Biotechnology Co. Ltd
Product
Ranolazine Dihydrochloride 95635-56-6
Price
US $10.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2021-11-19
Zhuozhou Wenxi import and Export Co., Ltd
Product
Ranolazine dihydrochloride 95635-56-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-26
Career Henan Chemical Co
Product
Ranolazine dihydrochloride 95635-56-6
Price
US $100.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2018-08-01

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