ChemicalBook > CAS DataBase List > 6-HYDROXY-2-NAPHTHYL DISULFIDE

6-HYDROXY-2-NAPHTHYL DISULFIDE

Product Name
6-HYDROXY-2-NAPHTHYL DISULFIDE
CAS No.
6088-51-3
Chemical Name
6-HYDROXY-2-NAPHTHYL DISULFIDE
Synonyms
DDD;DDD0;PIR 3.5;6,6'DDD (Analytical);AKOS BBS-00001974;TIMTEC-BB SBB005947;6′-Dithiodi(2-naphthol);6,6'-Dithiodi-2-naphthtol;6,6'-DITHIODI(2-NAPHTHOL)
CBNumber
CB8198578
Molecular Formula
C20H14O2S2
Formula Weight
350.45
MOL File
6088-51-3.mol
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6-HYDROXY-2-NAPHTHYL DISULFIDE Property

Melting point:
226 °C
Boiling point:
597.5±25.0 °C(Predicted)
Density 
1.46±0.1 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
<26.28mg/ml in DMSO
form 
powder to crystal
pka
8.93±0.40(Predicted)
color 
White to Brown
Merck 
14,2840
CAS DataBase Reference
6088-51-3(CAS DataBase Reference)
EPA Substance Registry System
2-Naphthalenol, 6,6'-dithiobis- (6088-51-3)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HS Code 
2908990090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D0244
Product name
Bis(6-hydroxy-2-naphthyl) Disulfide
Purity
>95.0%(HPLC)
Packaging
1g
Price
$114
Updated
2024/03/01
Tocris
Product number
4212
Product name
PIR3.5
Purity
≥98%(HPLC)
Packaging
10
Price
$115
Updated
2021/12/16
Tocris
Product number
4212
Product name
PIR3.5
Purity
≥98%(HPLC)
Packaging
50
Price
$388
Updated
2021/12/16
Usbiological
Product number
256259
Product name
PIR 3.5
Packaging
10mg
Price
$366
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD67127
Product name
2,2'-Dihydroxy-6,6'-dinaphthyldisulphide
Packaging
10g
Price
$376
Updated
2021/12/16
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6-HYDROXY-2-NAPHTHYL DISULFIDE Chemical Properties,Usage,Production

Description

DDD, 1,1-dichloro-2,2-bis-(4-chlorophenyl) ethane, also known as TDE, is a metabolite of DDT, which found use in agriculture. As with DDT, the p,p -isomer is insecticidal and the o,p -isomer is an impurity.

Uses

For determination of protein-bound sulfhydryl groups.

Purification Methods

It crystallises as leaflets from AcOH and is slightly soluble in EtOH, and AcOH, but is soluble in *C6H6 and in alkalis to give a yellow solution. [Zincke & Dereser Chem Ber 51 352 1918.] The acetoxy derivative has m 198-200o (from AcOH or dioxane/MeOH), and the diacetyl derivative has m 167-168o (from AcOH). A small amount of impure disulfide can be purified by dissolving it in a small volume of Me2CO and adding a large volume of toluene, filter rapidly and concentrate to one-third of its volume. The hot toluene solution is filtered rapidly from any tarry residue, and crystals separate on cooling. Recrystallisation from hot acetic acid gives crystals with m 220-223o [Barrett & Seligman Science 116 323 1952]. [Beilstein 6 I 481.]

Toxicity evaluation

Animal Studies. DDD is less acutely toxic than DDT (29), with an oral LD50 of 3400 to 4000 mg/kg in the rat and a dermal LD50 ca. 1200 mg/kg in the rabbit. In a 2-year chronic dietary study in the rat, a LOEL of 100 ppm (5 mg/kg/day) was quoted for tissue damage, similar to that produced by DDT.
Human Studies. Most of the studies conducted in humans have used the o,p -isomer of DDD. This has been used as a drug, with medical and veterinary uses, for the treatment of Cushing’s syndrome and adrenal carcinoma, under the generic name of mitotane. After oral ingestion, o,p’-DDD binds to lung and adrenal tissue. Its toxicity to the adrenal appears to be species-dependent, however, causing gross atrophy in the dog and reducing corticosteroid production without pathological effects in other mammals, including humans.

6-HYDROXY-2-NAPHTHYL DISULFIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-HYDROXY-2-NAPHTHYL DISULFIDE Suppliers

J & K SCIENTIFIC LTD.
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6088-51-3, 6-HYDROXY-2-NAPHTHYL DISULFIDERelated Search:


  • 6,6'-Dithiodi-2-naphthtol
  • PIR 3.5
  • DDD (Analytical)
  • DDD 6,6'-Dihydroxy-2,2'-dinaphthyl Disulfide 6-Hydroxy-2-naphthyl Disulfide
  • 2-Naphthalenol,6,6'-dithiobis-
  • 6,6&apos
  • Bis(2-hydroxy-6-naphthyl) disulfide
  • TIMTEC-BB SBB005947
  • 6,6’-dithiobis-2-naphthaleno
  • BIS(6-HYDROXY-2-NAPHTHYL) DISULFIDE
  • DDD
  • 2,2'-DIHYDROXY-6,6'-DINAPHTHYL DISULFIDE
  • 2,2'-DIHYDROXY-6,6'-DINAPHTHYLDISULPHIDE
  • 6,6'-DITHIODI(2-NAPHTHOL)
  • 6,6'-DIHYDROXY-2,2'-DINAPHTHYL DISULFIDE
  • 6-HYDROXY-2-NAPHTHYL DISULFIDE
  • AKOS BBS-00001974
  • 6-HYDROXY-2-NAPHTHYL DISULFIDE 98%
  • 6-HYDROXY-2-NAPHTHYLDISULPHIDE
  • 6-HYDROXY-2-NAPHTHYL DISULFIDE 98+%
  • 6,6μ-Dihydroxy-2,2μ-dinaphthyl disulfide, 6-Hydroxy-2-naphthyl disulfide, Bis(6-hydroxy-2-naphthyl) disulfide
  • 2,2μ-Dihydroxy-6,6μ-dinaphthyl disulfide, 6,6μ-Dihydroxy-2,2μ-dinaphthyl disulfide, 6,6μ-Dithiodi(2-naphthol), 6,6μ-Dithiodi-2-naphthol, Bis(2-hydroxy-6-naphthyl) disulfide, Bis(6-hydroxy-2-naphthyl) disulfide, DDD
  • [6,6'-Dithiodinaphthalene]-2,2'-diol
  • 6,6'-Dithiobis(2-naphthol)
  • Bis(6-hydroxy-2-naphtyl) persulfide
  • DDD0
  • 6-[(6-hydroxy-2-naphthalenyl)disulfanyl]-2-naphthalenol
  • 6,6'-Disulfanediylbis(naphthalen-2-ol)
  • Bis(6-hydroxy-2-naphthyl) Disulfide &gt
  • 6′-Dithiodi(2-naphthol)
  • 6088-51-3
  • HOC10H6S2
  • C20H14O2S2
  • BioChemical
  • Biochemicals and Reagents
  • Sulfur Compounds (for Synthesis)
  • Detection
  • Fluorescent Probes, Labels, Particles and Stains
  • Sulfur Compounds (for Synthesis)
  • Synthetic Organic Chemistry