6-HYDROXY-2-NAPHTHYL DISULFIDE
- Product Name
- 6-HYDROXY-2-NAPHTHYL DISULFIDE
- CAS No.
- 6088-51-3
- Chemical Name
- 6-HYDROXY-2-NAPHTHYL DISULFIDE
- Synonyms
- DDD;DDD0;PIR 3.5;6,6'DDD (Analytical);AKOS BBS-00001974;TIMTEC-BB SBB005947;6′-Dithiodi(2-naphthol);6,6'-Dithiodi-2-naphthtol;6,6'-DITHIODI(2-NAPHTHOL)
- CBNumber
- CB8198578
- Molecular Formula
- C20H14O2S2
- Formula Weight
- 350.45
- MOL File
- 6088-51-3.mol
6-HYDROXY-2-NAPHTHYL DISULFIDE Property
- Melting point:
- 226 °C
- Boiling point:
- 597.5±25.0 °C(Predicted)
- Density
- 1.46±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- <26.28mg/ml in DMSO
- form
- powder to crystal
- pka
- 8.93±0.40(Predicted)
- color
- White to Brown
- Merck
- 14,2840
- CAS DataBase Reference
- 6088-51-3(CAS DataBase Reference)
- EPA Substance Registry System
- 2-Naphthalenol, 6,6'-dithiobis- (6088-51-3)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- D0244
- Product name
- Bis(6-hydroxy-2-naphthyl) Disulfide
- Purity
- >95.0%(HPLC)
- Packaging
- 1g
- Price
- $114
- Updated
- 2024/03/01
- Product number
- 4212
- Product name
- PIR3.5
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $115
- Updated
- 2021/12/16
- Product number
- 4212
- Product name
- PIR3.5
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $388
- Updated
- 2021/12/16
- Product number
- 256259
- Product name
- PIR 3.5
- Packaging
- 10mg
- Price
- $366
- Updated
- 2021/12/16
- Product number
- FD67127
- Product name
- 2,2'-Dihydroxy-6,6'-dinaphthyldisulphide
- Packaging
- 10g
- Price
- $376
- Updated
- 2021/12/16
6-HYDROXY-2-NAPHTHYL DISULFIDE Chemical Properties,Usage,Production
Description
DDD, 1,1-dichloro-2,2-bis-(4-chlorophenyl) ethane, also known as TDE, is a metabolite of DDT, which found use in agriculture. As with DDT, the p,p -isomer is insecticidal and the o,p -isomer is an impurity.
Uses
For determination of protein-bound sulfhydryl groups.
Purification Methods
It crystallises as leaflets from AcOH and is slightly soluble in EtOH, and AcOH, but is soluble in *C6H6 and in alkalis to give a yellow solution. [Zincke & Dereser Chem Ber 51 352 1918.] The acetoxy derivative has m 198-200o (from AcOH or dioxane/MeOH), and the diacetyl derivative has m 167-168o (from AcOH). A small amount of impure disulfide can be purified by dissolving it in a small volume of Me2CO and adding a large volume of toluene, filter rapidly and concentrate to one-third of its volume. The hot toluene solution is filtered rapidly from any tarry residue, and crystals separate on cooling. Recrystallisation from hot acetic acid gives crystals with m 220-223o [Barrett & Seligman Science 116 323 1952]. [Beilstein 6 I 481.]
Toxicity evaluation
Animal Studies. DDD is less acutely toxic
than DDT (29), with an oral LD50 of 3400 to 4000 mg/kg in
the rat and a dermal LD50 ca. 1200 mg/kg in the rabbit. In a
2-year chronic dietary study in the rat, a LOEL of 100 ppm
(5 mg/kg/day) was quoted for tissue damage, similar to that
produced by DDT.
Human Studies. Most of the studies conducted in
humans have used the o,p -isomer of DDD. This has been
used as a drug, with medical and veterinary uses, for the
treatment of Cushing’s syndrome and adrenal carcinoma,
under the generic name of mitotane. After oral ingestion,
o,p’-DDD binds to lung and adrenal tissue. Its toxicity to the
adrenal appears to be species-dependent, however, causing
gross atrophy in the dog and reducing corticosteroid
production without pathological effects in other mammals,
including humans.
6-HYDROXY-2-NAPHTHYL DISULFIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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