1-BENZHYDRYLAZETIDIN-3-ONE

Product Name: 1-BENZHYDRYLAZETIDIN-3-ONE
CAS No.: 40320-60-3
Chemical Name: 1-BENZHYDRYLAZETIDIN-3-ONE
Synonyms: 1-(DIPHENYLMETHYL)AZETIDIN-3-ONE;1-benzhdrylazetidin-3-one;3-BENZHYDRYL-CYCLOBUTANONE;1-BENZHYDRYLAZETIDIN-3-ONE;N-Benzhydrylazetidin-3-one;1-Diphenylmethyl-3-azetid...;N-DiphenylMethylazetidin-3-on;1-Diphenylmethyl-3-azetidinone;1-Benzhydrylazetidin-3-one 95%;1-Benzhydryl-3-azetidinone >
CBNumber: CB8199186
Molecular Formula: C16H15NO
Formula Weight: 237.3
MOL File: 40320-60-3.mol

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1-BENZHYDRYLAZETIDIN-3-ONE Property

Melting point:: 75.0 to 79.0 °C
Boiling point:: 350-355℃
Density: 1.182
Flash point:: 156°(313°F)
refractive index: 1.626
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
pka: 3.10±0.20(Predicted)
color: White to Orange to Green
InChI: InChI=1S/C16H15NO/c18-15-11-17(12-15)16(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10,16H,11-12H2
InChIKey: AVUDXLOVIBJFQA-UHFFFAOYSA-N
SMILES: N1(C(C2=CC=CC=C2)C2=CC=CC=C2)CC(=O)C1

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Safety

Safety Statements: 24/25
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B4799
Product name: 1-Benzhydryl-3-azetidinone
Purity: >96.0%(GC)(T)
Packaging: 1g
Price: $59
Updated: 2025/07/31

TCI Chemical

Product number: B4799
Product name: 1-Benzhydryl-3-azetidinone
Purity: >96.0%(GC)(T)
Packaging: 5g
Price: $198
Updated: 2025/07/31

TRC

Product number: B194860
Product name: 1-Benzhydrylazetidin-3-one
Packaging: 25g
Price: $140
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB09242
Product name: 1-Benzhydrylazetidin-3-one
Packaging: 50g
Price: $125
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H48-1-F5
Product name: 1-(Diphenylmethyl)azetidin-3-one
Purity: 95.0%
Packaging: 5G
Price: $152
Updated: 2021/12/16

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1-BENZHYDRYLAZETIDIN-3-ONE Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

1-Benzhydrylazetidin-3-one is used in the synthesis of azetidine derivatives as novel γ-aminobutyric acid uptake inhibitors.

Synthesis

90604-02-7

40320-60-3

General procedure for the synthesis of 1-diphenylmethylazetidin-3-one: (Preparative Example 78) To a mixture of 1-diphenylmethylazetidin-3-ol hydrochloride (5.52 g) and triethylamine (27.9 ml) was added slowly and dropwise a dimethylformamide solution (80 ml) of pyridine trioxide complex (19.7 g). The reaction mixture was stirred at 50 °C for 30 min and then cooled to room temperature. The reaction mixture was poured into ice water, extracted with ethyl acetate and the organic layer was washed with brine. Activated carbon (5 g) was added to the organic layer and stirred at room temperature for 3 days. The activated carbon was removed by filtration and the filtrate was concentrated. The residue was dissolved in methanol (200 ml), activated carbon (10 g) was added and stirred at room temperature for 3 days. The activated carbon was removed by filtration again and the filtrate was concentrated. The residue was purified by silica gel column chromatography (eluent: heptane/ethyl acetate = 4:1, then 2:1). The grades containing the target compound were collected and concentrated to give a light yellow oil (3.21 g). Hexane was added to the oily material to induce crystallization and the crystals were collected by filtration. The crystals were dried under ventilated conditions to give the title compound (1.11 g, 23.4% yield). The concentrated residue of the filtrate was added to hexane and left to crystallize at room temperature. After precipitation, the supernatant was removed by pipette and dried under reduced pressure to give the light yellow crystalline title compound (940 mg, 19.8% yield).1H-NMR (CDCl3) δ (ppm): 4.01 (4H, s), 4.60 (1H, s), 7.22 (2H, m), 7.30 (4H, m), 7.48 (4H, m).

References

[1] Patent: US2010/190771, 2010, A1. Location in patent: Page/Page column 38
[2] Journal of Medicinal Chemistry, 2017, vol. 60, # 16, p. 7029 - 7042
[3] Patent: WO2014/68527, 2014, A1. Location in patent: Page/Page column 83; 84
[4] Chemistry Letters, 1999, # 7, p. 605 - 606
[5] Patent: EP1889836, 2008, A1. Location in patent: Page/Page column 78

1-BENZHYDRYLAZETIDIN-3-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-BENZHYDRYLAZETIDIN-3-ONE Suppliers

Americas 1 Canada 1 China 191 Europe 1 India 20 Japan 1 Switzerland 1 United Kingdom 7 United States 21 Global 244

Carbosynth

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View Lastest Price from 1-BENZHYDRYLAZETIDIN-3-ONE manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 1-BENZHYDRYLAZETIDIN-3-ONE 40320-60-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-25

Career Henan Chemical Co

Product: 1-BENZHYDRYLAZETIDIN-3-ONE 40320-60-3
Price: US $1.00/KG
Min. Order: 1G
Purity: 98%
Supply Ability: 1000KG
Release date: 2018-08-10

40320-60-3, 1-BENZHYDRYLAZETIDIN-3-ONERelated Search:

1-TRIMETHYLSILYL-2-PYRROLIDINONE Cyclobutanone 1-Diphenylmethylazetidine 3-AZETIDINONE 1-(DIPHENYLMETHYL)-3-AZETIDINONE HYDROCHLORIDE 1-BENZYLAZETIDIN-3-ONE 1-BENZHYDRYLAZETIDIN-3-ONE

1-BENZHYDRYLAZETIDIN-3-ONE

1-Benzhydrylazetidin-3-one 95%

3-BENZHYDRYL-CYCLOBUTANONE

1-(DIPHENYLMETHYL)AZETIDIN-3-ONE

1-Diphenylmethyl-3-azetid...

1-(Diphenylmethyl)azetidin-3-one 95%

1-benzhdrylazetidin-3-one

1-Diphenylmethyl-3-azetidinone

1-(1,1-Diphenylmethyl)azetidin-3-one

3-Azetidinone, 1-(diphenylMethyl)-

1-[Bis(phenyl)Methyl]azetidin-3-one

N-Benzhydrylazetidin-3-one

N-DiphenylMethylazetidin-3-on

1-Benzhydrylazetidin-3-one, 1-(Diphenylmethyl)-3-oxoazetane

1-Benzhydryl-3-azetidinone &gt

1-Diphenylmethyl-3-azetidinone - [D6185]

40320-60-3

Amines

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Ring Systems