(S)-5-HYDROXY-PIPERIDIN-2-ONE
- Product Name
- (S)-5-HYDROXY-PIPERIDIN-2-ONE
- CAS No.
- 24211-54-9
- Chemical Name
- (S)-5-HYDROXY-PIPERIDIN-2-ONE
- Synonyms
- RARECHEM AK ML 0202;(S)-5-Hydroxy-2-piperidone;(S)-5-HYDROXY-PIPERIDIN-2-ON;(S)-5-Hydroxy-2-piperidinone;(S)-5-HYDROXY-PIPERIDIN-2-ONE;(5S)-5-Hydroxy-piperidin-2-one;2-Piperidinone, 5-hydroxy-, (5S)-;(-)-(5S)-5-hydroxy-piperidin-2-one;(5S)-5-hydroxypiperidin-2-one - [H85866]
- CBNumber
- CB8205483
- Molecular Formula
- C5H9NO2
- Formula Weight
- 115.13
- MOL File
- 24211-54-9.mol
(S)-5-HYDROXY-PIPERIDIN-2-ONE Property
- Melting point:
- 123-124℃ (methanol ethyl ether )
- Boiling point:
- 352.3±35.0 °C(Predicted)
- Density
- 1.199±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 14.21±0.20(Predicted)
- Appearance
- Off-white to light brown Solid
- InChI
- InChI=1S/C5H9NO2/c7-4-1-2-5(8)6-3-4/h4,7H,1-3H2,(H,6,8)/t4-/m0/s1
- InChIKey
- GPRZVNYVEZZOKH-BYPYZUCNSA-N
- SMILES
- N1C[C@@H](O)CCC1=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- H952218
- Product name
- (5S)-5-Hydroxy-2-piperidinone
- Packaging
- 100mg
- Price
- $115
- Updated
- 2021/12/16
- Product number
- CS-D0042
- Product name
- (S)-5-hydroxypiperidin-2-one
- Packaging
- 100mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- AS37180
- Product name
- (S)-5-Hydroxypiperidin-2-one
- Purity
- 95+% ee
- Packaging
- 250mg
- Price
- $381
- Updated
- 2021/12/16
- Product number
- CCH0003698
- Product name
- (S)-5-HYDROXY-PIPERIDIN-2-ONE
- Purity
- 95.00%
- Packaging
- 0.25G
- Price
- $396
- Updated
- 2021/12/16
- Product number
- AS37180
- Product name
- (S)-5-Hydroxypiperidin-2-one
- Purity
- 95+% ee
- Packaging
- 1g
- Price
- $765
- Updated
- 2021/12/16
(S)-5-HYDROXY-PIPERIDIN-2-ONE Chemical Properties,Usage,Production
Uses
(5S)-5-Hydroxy-2-piperidinone is used in the enantioselective synthesis of peptides containing cyclopropane pipecolic acid, which can be useful as proline mimetics for probing protein-ligand interactions and generating novel bioactive compounds.
Synthesis
24211-53-8
24211-54-9
The general procedure for the synthesis of (S)-5-hydroxypiperidin-2-one from the compound (CAS:24211-53-8) was as follows: azide 13 (1.5 g, 10.62 mmol) was dissolved in anhydrous methanol and 20% Pd(OH)2 (0.037 g, 0.53 mmol) was added. The reaction mixture was stirred at 25°C for 24 h under hydrogen (1 atm) atmosphere. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the catalyst was removed by diatomaceous earth filtration and the filtrate was concentrated under reduced pressure to afford the crude product (S)-5-hydroxypiperidin-2-one. The crude product was purified by column chromatography using ethyl acetate and methanol (9:1, v/v) as eluent to finally obtain pure (S)-5-hydroxypiperidin-2-one 14 (1.19 g, 98% yield).
References
[1] Synthetic Communications, 2015, vol. 45, # 13, p. 1559 - 1565
[2] Tetrahedron, 1995, vol. 51, # 21, p. 5935 - 5950
[3] Tetrahedron Letters, 2005, vol. 46, # 8, p. 1247 - 1249
[4] Synthesis, 1986, vol. NO. 3, p. 232 - 233
[5] Journal of Organic Chemistry, 1985, vol. 50, # 6, p. 896 - 899
(S)-5-HYDROXY-PIPERIDIN-2-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (S)-5-HYDROXY-PIPERIDIN-2-ONE manufacturers
- Product
- (S)-5-HYDROXY-PIPERIDIN-2-ONE 24211-54-9
- Price
- US $5.50/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 1kg-100kg
- Release date
- 2020-01-10