Thiazole,5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-
- Product Name
- Thiazole,5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-
- CAS No.
- 317318-97-1
- Chemical Name
- Thiazole,5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-
- Synonyms
- ChloroMethylthiazole;5-Chloromethyl-4-methyl-2-(4-trifluoromethylphenyl)thiazole;4-[5-(Chloromethyl)-4-methyl-1,3-thiazol-2-yl]benzotrifluoride;5-(Chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-...;Thiazole,5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-;5-(Chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole
- CBNumber
- CB82077394
- Molecular Formula
- C12H9ClF3NS
- Formula Weight
- 291.72
- MOL File
- 317318-97-1.mol
Thiazole,5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]- Property
- Melting point:
- 60-62°
- Boiling point:
- 363.5±52.0 °C(Predicted)
- Density
- 1.357±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform, Methanol
- form
- Solid
- pka
- 1.62±0.10(Predicted)
- color
- Yellow
Safety
- HazardClass
- IRRITANT
- HS Code
- 2934100090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H290May be corrosive to metals
H302Harmful if swallowed
H318Causes serious eye damage
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P270Do not eat, drink or smoke when using this product.
P281Use personal protective equipment as required.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P330Rinse mouth.
P390Absorb spillage to prevent material damage.
N-Bromosuccinimide Price
- Product number
- C379930
- Product name
- 5-Chloromethyl-4-methyl-2-(4-trifluoromethylphenyl)thiazole
- Packaging
- 10mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- PC10200
- Product name
- 5-(Chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole
- Packaging
- 1g
- Price
- $11
- Updated
- 2021/12/16
- Product number
- 7H70-7-05
- Product name
- 5-(Chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole
- Packaging
- 1g
- Price
- $18
- Updated
- 2021/12/16
- Product number
- 043677
- Product name
- 5-(Chloromethyl)-4-methyl-2-[4-(trifluoromethyl)-phenyl]-1,3-thiazole
- Purity
- >95%
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
- Product number
- FC20279
- Product name
- 5-Chloromethyl-4-methyl-2-(4-trifluoromethylphenyl)thiazole
- Packaging
- 5mg
- Price
- $70
- Updated
- 2021/12/16
Thiazole,5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]- Chemical Properties,Usage,Production
Chemical Properties
Yellow Solid
Uses
Intermediate in the production of GW 501516 and its derivatives
Synthesis
639784-17-1
121-44-8
317318-97-1
To a stirred solution of Intermediate 1 (8.2 g, 30 mmol) and triethylamine (6.07 g, 8.36 mL, 60 mmol) in anhydrous dichloromethane (120 mL) at 0 °C was slowly added methanesulfonyl chloride (5.49 g, 3.71 mL, 48 mmol). After 2 hours of reaction at 0°C, additional triethylamine (6 mmol) and methanesulfonyl chloride (4.8 mmol) were added. After 2 hours of reaction, thin layer chromatography (TLC, unfolding agent: hexane/ethyl acetate, 1:1) showed complete reaction. The reaction mixture was diluted with dichloromethane (120 mL) and washed sequentially with saturated sodium bicarbonate solution (2 x 240 mL) and water (2 x 240 mL), and the organic phase was dried, filtered, and concentrated to afford 5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole (8.0 g, 27 mmol, 90% yield) as a yellow solid.
References
[1] Patent: WO2004/785, 2003, A2. Location in patent: Page 43
Thiazole,5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Thiazole,5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]- manufacturers
- Product
- Thiazole,5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]- 317318-97-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 150KG
- Release date
- 2019-07-01