α-Ketoglutaric acid-d6, α-Ketopentanoic acid-d6
- Product Name
- α-Ketoglutaric acid-d6, α-Ketopentanoic acid-d6
- CAS No.
- 1173021-86-7
- Chemical Name
- α-Ketoglutaric acid-d6, α-Ketopentanoic acid-d6
- Synonyms
- EOS-60378;α-Ketoglutaric acid-d6;2-Ketoglutaric acid-d6;α-Ketopentanoic acid-d6;2-Ketopentanedioic acid-d6;α-Ketoglutaric acid (D?, 98%);2-Oxo-1,5-pentanedioic Acid-d6;2-Ketoglutaric acid-d6;ALPHA-KETOGLUTARIC ACID (D6, 98%);2-oxopentanedioic-3,3,4,4-d4acid-d2
- CBNumber
- CB82092289
- Molecular Formula
- C5D6O5
- Formula Weight
- 152.135110668
- MOL File
- 1173021-86-7.mol
α-Ketoglutaric acid-d6, α-Ketopentanoic acid-d6 Property
- Melting point:
- 114-117 °C
- form
- Solid
- color
- White to off-white
- CAS Number Unlabeled
- 328-50-7
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- RDL0001552
- Product name
- 2-KETOPENTANEDIOIC ACID-D6
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $900.94
- Updated
- 2021/12/16
- Product number
- RDL0001552
- Product name
- 2-KETOPENTANEDIOIC ACID-D6
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $2312.5
- Updated
- 2021/12/16
α-Ketoglutaric acid-d6, α-Ketopentanoic acid-d6 Chemical Properties,Usage,Production
Uses
2-Ketoglutaric acid-d6 is the deuterium labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].
References
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Huergo LF, et al. The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite. Microbiol Mol Biol Rev. 2015 Dec;79(4):419-35. DOI:10.1128/MMBR.00038-15
[3] Gou L, et al. The effect of alpha-ketoglutaric acid on tyrosinase activity and conformation: Kinetics and molecular dynamics simulation study. Int J Biol Macromol. 2017 Dec105(Pt 3):1654-1662. DOI:10.1016/j.ijbiomac.2016.12.015
α-Ketoglutaric acid-d6, α-Ketopentanoic acid-d6 Preparation Products And Raw materials
Raw materials
Preparation Products
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