1-(3-Nitrophenyl)piperazine

Product Name: 1-(3-Nitrophenyl)piperazine
CAS No.: 54054-85-2
Chemical Name: 1-(3-Nitrophenyl)piperazine
Synonyms: 1-(3-NITROPHENYL)-PIPERAZINE;Piperazine, 1-(3-nitrophenyl)-;1-(3-nitrobenzophenone)piperazidine
CBNumber: CB82129600
Molecular Formula: C10H13N3O2
Formula Weight: 207.23
MOL File: 54054-85-2.mol

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1-(3-Nitrophenyl)piperazine Property

Melting point:: 222-228 °C (decomp)
Boiling point:: 377.5±27.0 °C(Predicted)
Density: 1.222±0.06 g/cm3(Predicted)
storage temp.: Storage temp. 2-8°C
pka: 8.75±0.10(Predicted)
Appearance: Light yellow to yellow Solid

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Safety

RIDADR: UN3259
HazardClass: 8

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: N545313
Product name: 1-(3-Nitrophenyl)piperazine
Packaging: 100mg
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: W6842
Product name: 1-(3-Nitrophenyl)piperazine
Packaging: 1g
Price: $21
Updated: 2021/12/16

Matrix Scientific

Product number: 076542
Product name: 1-(3-Nitrophenyl)piperazine
Purity: 95+%
Packaging: 1g
Price: $116
Updated: 2021/12/16

AK Scientific

Product number: W6842
Product name: 1-(3-Nitrophenyl)piperazine
Packaging: 25g
Price: $168
Updated: 2021/12/16

Matrix Scientific

Product number: 076542
Product name: 1-(3-Nitrophenyl)piperazine
Purity: 95+%
Packaging: 5g
Price: $301
Updated: 2021/12/16

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1-(3-Nitrophenyl)piperazine Chemical Properties,Usage,Production

Synthesis

110-85-0

402-67-5

54054-85-2

1. 28.4 g (0.33 mol, 5.5 equiv) of piperazine is dissolved in 50 mL of DMSO. 2. 6.4 mL (60 mmol) of m-fluoronitrobenzene is added to this solution. 2. 6.4 mL (60 mmol) of m-fluoronitrobenzene was added to the above solution. 3. The reaction mixture was heated at 100°C for 60 hours. 4. 4. When the reaction is complete, cool to room temperature and slowly pour the mixture into 530 mL of water. 5. The precipitate formed was collected by filtration and the filtrate was extracted with ether (Et2O). 6. 6. The organic phases were combined, dried over anhydrous magnesium sulfate (MgSO4), and concentrated under reduced pressure. 7. The crude product was purified by column chromatography using a solvent mixture of dichloromethane (CH2Cl2) and methanol (MeOH) (9:1, v/v/v) as eluent. 8. The target component was collected and concentrated under reduced pressure to give 8.04 g of orange oil, which was crystallized as 1-(3-nitrophenyl)piperazine after standing at room temperature in 65% yield. Compound characterization data. Molecular formula: C10H13N3O2 Molecular weight: 207.26 g/mol 1H NMR (CDCl3) δ (ppm): 7.70 (t, J = 2 Hz, 1H, H-2'); 7.64 (ddd, J = 8 Hz, 2 Hz, 0.6 Hz, 1H, H-4'); 7.36 (t, J = 8 Hz, 1H, H-5'); 7.17 (ddd, J = 8 Hz, 2 Hz, 0.6 Hz, 1H, H-6') ; 3.30-3.18 (m, 4H, H-3, H-5); 3.09-2.97 (m, 4H, H-2, H-6).

References

[1] Patent: EP1683790, 2006, A1. Location in patent: Page/Page column 7; 12
[2] Patent: US2003/55055, 2003, A1
[3] Patent: WO2004/89912, 2004, A1. Location in patent: Page 26
[4] Patent: US2004/58933, 2004, A1. Location in patent: Page/Page column 37
[5] Patent: US2005/267126, 2005, A1. Location in patent: Page/Page column 9

1-(3-Nitrophenyl)piperazine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(3-Nitrophenyl)piperazine Suppliers

China 57 Germany 1 India 1 Ukraine 1 United Kingdom 2 United States 12 Global 74

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54054-85-2, 1-(3-Nitrophenyl)piperazineRelated Search:

1-(3-NITROPHENYL)-PIPERAZINE

1-(3-nitrobenzophenone)piperazidine

Piperazine, 1-(3-nitrophenyl)-

54054-85-2