4-CHLORO-1-METHYL-6-OXO-1,6-DIHYDRO-PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER
- Product Name
- 4-CHLORO-1-METHYL-6-OXO-1,6-DIHYDRO-PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER
- CAS No.
- 821791-58-6
- Chemical Name
- 4-CHLORO-1-METHYL-6-OXO-1,6-DIHYDRO-PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER
- Synonyms
- ethyl 4-chloro-1-methyl-6-oxopyridine-3-carboxylate;ethyl 4-chloro-1,6-dihydro-1-Methyl-6-oxopyridine-3-carboxylate;ETHYL 4-CHLORO-1-METHYL-6-OXO-1,6-DIHYDROPYRIDINE-3-CARBOXYLATE;4-CHLORO-1-METHYL-6-OXO-1,6-DIHYDRO-PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER;3-Pyridinecarboxylicacid, 4-chloro-1,6-dihydro-1-Methyl-6-oxo-, ethyl ester
- CBNumber
- CB8213053
- Molecular Formula
- C9H10ClNO3
- Formula Weight
- 215.63
- MOL File
- 821791-58-6.mol
4-CHLORO-1-METHYL-6-OXO-1,6-DIHYDRO-PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER Property
- Boiling point:
- 302.4±42.0 °C(Predicted)
- Density
- 1.31±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- -3.05±0.62(Predicted)
- Appearance
- Yellow to brown Solid
N-Bromosuccinimide Price
- Product number
- 054233
- Product name
- Ethyl 4-chloro-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylate
- Purity
- >95%
- Packaging
- 500mg
- Price
- $275
- Updated
- 2021/12/16
- Product number
- 054233
- Product name
- Ethyl 4-chloro-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylate
- Purity
- >95%
- Packaging
- 1g
- Price
- $340
- Updated
- 2021/12/16
- Product number
- 9385CS
- Product name
- Ethyl4-chloro-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate
- Packaging
- 1g
- Price
- $504
- Updated
- 2021/12/16
- Product number
- HCH0047243
- Product name
- 4-CHLORO-1-METHYL-6-OXO-1,6-DIHYDROPYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $866.13
- Updated
- 2021/12/16
- Product number
- 054233
- Product name
- Ethyl 4-chloro-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxylate
- Purity
- >95%
- Packaging
- 5g
- Price
- $1000
- Updated
- 2021/12/16
4-CHLORO-1-METHYL-6-OXO-1,6-DIHYDRO-PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production
Synthesis
853105-37-0
821791-58-6
(Step 2) To ethyl 4-hydroxy-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate (9.2 g, 47 mmol) obtained in Step 1 was added phosphorous trichloride (26.1 mL, 280 mmol) and triethylamine (6.5 mL, 47 mmol). The reaction mixture was stirred at 50 °C for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the solvent was removed by evaporation under reduced pressure. Saturated aqueous sodium bicarbonate (100 mL) was added to the residue, which was subsequently extracted with ethyl acetate (3 × 50 mL). The organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford ethyl 4-chloro-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate (6.0 g, 60% yield). The product was confirmed by electrospray ionization mass spectrometry (ESIMS), m/z: 216 (M + H)+.
References
[1] Patent: EP2930170, 2015, A1. Location in patent: Paragraph 0253
[2] Journal of Medicinal Chemistry, 2006, vol. 49, # 2, p. 441 - 444
[3] Patent: US2005/256123, 2005, A1
4-CHLORO-1-METHYL-6-OXO-1,6-DIHYDRO-PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
4-CHLORO-1-METHYL-6-OXO-1,6-DIHYDRO-PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER Suppliers
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- --
- Fax
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- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from 4-CHLORO-1-METHYL-6-OXO-1,6-DIHYDRO-PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER manufacturers
- Product
- ethyl 4-chloro-1-methyl-6-oxopyridine-3-carboxylate 821791-58-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2020-02-04