2-Mercaptoethanol Property

Melting point:

-100 °C

Boiling point:

157 °C (lit.)

Density 

1.114 g/mL at 25 °C (lit.)

vapor density 

2.69 (vs air)

vapor pressure 

1 mm Hg ( 20 °C)

refractive index 

n20/D 1.500(lit.)

FEMA 

4582 | 2-HYDROXYETHANETHIOL

Flash point:

165 °F

storage temp. 

Store below +30°C.

solubility 

H₂O: 1 mL/mL

form 

liquid

pka

9.72(at 25℃)

Specific Gravity

1.119 (20/4℃)

color 

Clear colorless to slightly yellow

PH

4.5-6 (500g/l, H2O, 20℃)

Odor

Disagreeable odor

PH Range

4.5 - 6 at 500 g/l at 20 °C

explosive limit

2.3-18%(V)

Water Solubility 

soluble

FreezingPoint 

<100℃

Sensitive 

Air Sensitive & Hygroscopic

λmax

λ: 260 nm Amax: 1.5
λ: 280 nm Amax: 0.3

Merck 

14,5869

JECFA Number

1925

BRN 

773648

Stability:

Air Sensitive

LogP

-0.20

CAS DataBase Reference

60-24-2(CAS DataBase Reference)

NIST Chemistry Reference

Ethanol, 2-mercapto-(60-24-2)

EPA Substance Registry System

2-Mercaptoethanol (60-24-2)

Safety

Hazard Codes 

T,N

Risk Statements 

20/22-24-34-51/53-36/37/38-22-23/24/25-50/53-48/22-43-41-38

Safety Statements 

26-36/37/39-45-61-29-23-27-60

RIDADR 

UN 2966 6.1/PG 2

WGK Germany 

3

RTECS 

KL5600000

F 

3-10-13-23

Autoignition Temperature

295 °C

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

II

HS Code 

29309070

Hazardous Substances Data

60-24-2(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H310Fatal in contact with skin

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

H373May cause damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

2-Mercaptoethanol Chemical Properties,Usage,Production

Chemical Properties

2-mercaptoethanol(bME) is a clear colorless liquid. It is a popular effective reducer, but extremely pungent.

Uses

2-Mercaptoethanol is used in the preparation of nano-graphene for cellular imaging and drug delivery as well as multifunctional polymeric micelle. It acts as a reducing agent used in electrophoresis, amino acid detection, and distinguishing ssDNA/dsDNA. It is also employed as a standard buffer. It is also used in the preparation of PVC heat stabilizers and as a chain transfer agent in the manufacture of PVC. Further, it is used in some RNA isolation procedures to eliminate ribonuclease. It is utilized as a corrosion inhibitor and ore floatation agent. In biochemistry, it is useful to study the activity of the immune system. Solubilizes proteins by reducing disulfide linkages.

Definition

ChEBI: 2-Mercaptoethanol is a primary alcohol and an alkanethiol. It has a role as a geroprotector.

Application

2-Mercaptoethanol is used in the synthesis of nano-graphene for cellular imaging and drug delivery. Also used in the synthesis of multifunctional polymeric micelle used in specific targeting of tumor disruption.

General Description

A water-white liquid. May be toxic by ingestion, inhalation, or skin absorption.

Air & Water Reactions

No rapid reaction with air. No rapid reaction with water.

Reactivity Profile

Organosulfides, such as 2-Mercaptoethanol, are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid.

Hazard

Toxic by inhalation and ingestion.

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Combustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

Safety Profile

Poison by ingestion, skin contact, and intraperitoneal routes. Moderately toxic by intravenous route. A skin and severe eye irritant. Human mutation data reported. A combustible liquid when exposed to heat, flame, or oxidizers. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits highly toxic fumes of SOx. See also MERCAPTANS.

Purification Methods

Purify it by distilling in a vacuum. Distilling at atmospheric pressure causes some oxidation and should be done in an inert atmosphere. [Woodward J Chem Soc 1892 1948.] It has a foul odour, is irritating t o the eyes, nose and skin — should be handled in an efficient fume cupboard. It is miscible with H2O, EtOH, Et2O and *C6H6 and the UV has max at 235nm. The 2,4-dinitrophenyl thioether has m 101-102o (from EtOH or aqueous MeOH) [Grogen et al. J Org Chem 20 50 1955]. [Beilstein 1 IV 2428.]