Appearance Solubility
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N-OCTYLPHOSPHONIC ACID

Appearance Solubility
Product Name
N-OCTYLPHOSPHONIC ACID
CAS No.
4724-48-5
Chemical Name
N-OCTYLPHOSPHONIC ACID
Synonyms
Octylphosphonsure;1-octyl phosphate;octyl-phosphonicaci;octyl-Phosphonicacid;Octanephosphonic acid;N-OCTYLPHOSPHONIC ACID;1-OCTYLPHOSPHONIC ACID;1-0ctylphosphonic acid;1-Octanephosphonic acid;Phosphonic acid, octyl-
CBNumber
CB8218159
Molecular Formula
C8H19O3P
Formula Weight
194.21
MOL File
4724-48-5.mol
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N-OCTYLPHOSPHONIC ACID Property

Melting point:
100-102°C
Boiling point:
170 °C(Press: 0.05 Torr)
Density 
1.080±0.06 g/cm3(Predicted)
vapor pressure 
0Pa at 25℃
storage temp. 
Sealed in dry,Room Temperature
solubility 
soluble in Methanol
pka
2.69±0.10(Predicted)
form 
Powder
color 
white to off-white
Specific Gravity
1.10
Water Solubility 
Slightly soluble in organic solvents and water.
Hydrolytic Sensitivity
4: no reaction with water under neutral conditions
BRN 
1764242
InChIKey
NJGCRMAPOWGWMW-UHFFFAOYSA-N
LogP
2.7 at 25℃
EPA Substance Registry System
Phosphonic acid, octyl- (4724-48-5)
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Safety

Hazard Codes 
C
Risk Statements 
36/37/38-48/22-34-22
Safety Statements 
26-36/37/39-45
RIDADR 
UN 3261 8 / PGII
WGK Germany 
2
TSCA 
Yes
HazardClass 
8
PackingGroup 
III
HS Code 
29319090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P314Get medical advice/attention if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
735914
Product name
Octylphosphonic acid
Purity
97%
Packaging
1g
Price
$76.8
Updated
2025/07/31
Sigma-Aldrich
Product number
735914
Product name
Octylphosphonic acid
Purity
97%
Packaging
5g
Price
$267
Updated
2025/07/31
TCI Chemical
Product number
O0380
Product name
n-Octylphosphonic Acid
Purity
>98.0%(T)
Packaging
1g
Price
$63
Updated
2025/07/31
TCI Chemical
Product number
O0380
Product name
n-Octylphosphonic Acid
Purity
>98.0%(T)
Packaging
5g
Price
$209
Updated
2025/07/31
Strem Chemicals
Product number
15-3520
Product name
n-Octylphosphonic acid, min. 97% OPA
Packaging
1g
Price
$51
Updated
2024/03/01
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N-OCTYLPHOSPHONIC ACID Chemical Properties,Usage,Production

Appearance

N-octylphosphonic acid is a white to off-white solid.

Solubility

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly).

Uses

1-Octylphosphonic acid is a basic building block and used in the preparation of various pharmaceutical compounds and chemical products. It is supported with calcium hydroxyapatite and used in the dental field as corrosion inhibitor and organic building block. It acts as a corrosion inhibitor in metallic household surfaces such as faucets and drains as well as prevents the rusting of can or dispenser. It is also used in the synthesis of octyl-phosphonic acid dimethyl ester by reacting with iodomethane in presence of CS2 CO3.

Uses

OPA can be used as a surfactant that may be added to silver (Ag)/titanium oxide (TiO2) for uniform dispersion into the polymeric matrix. It may be coated on indium-tin oxide (ITO) substrates, which can be used for super-resolution microscopy. OPA based charge blocking layer may be used to prevent leakage of current in a hybrid dielectric film.

General Description

Octylphosphonic acid (OPA) forms a self-assembled monolayer (SAM), which serves as a protective anti-corrosive phosphonate layer on a variety of surfaces.

Flammability and Explosibility

Non flammable

Synthesis

111-83-1

4724-48-5

General procedure for the synthesis of octylphosphonic acid from 1-bromooctane: 2.5 ml of 1-bromooctane was added to a 1000 ml flask, followed by 12.9 g of aluminum trichloride and stirred well at room temperature. The mixture was heated to 85°C and 1.0 mole of triethyl phosphite was slowly added dropwise, controlling the temperature between 85°C and 105°C. The dropwise process lasted for 3.0 hours. Upon completion of the dropwise addition, the reaction temperature was raised to 160 °C, and the reaction was continued at this temperature for 4 hours. At the end of the reaction, the system was cooled to 80°C and 506.0 g of 40% aqueous hydrogen bromide solution was slowly added dropwise for 60 minutes. After the dropwise addition, the system was heated to reflux and the reaction was maintained for 4 hours. Upon completion of the reaction, the aqueous hydrogen bromide solution was removed by atmospheric pressure distillation at 105 °C to recover the hydrogen bromide. Subsequently, 1-bromooctane was distilled at 90 °C under a vacuum of 1.0 kPa. After the system was cooled to room temperature, a mixed solution of n-hexane and water with a volume ratio of 6:1 was added to the reactor, which was thoroughly mixed and transferred to a separatory funnel for liquid-liquid separation. After separation, the lower aqueous phase was recovered, and the upper organic phase was transferred to a flask, and the hexane was removed and recovered by distillation at atmospheric pressure and 85 °C to finally obtain octylphosphonic acid. The yield of the reaction was 95.1% and the chromatographic purity of the product was 98.2% after sampling and analysis.

References

[1] Patent: CN105153224, 2017, B. Location in patent: Paragraph 0025; 0026; 0027; 0028; 0029; 0030; 0031-0036
[2] Journal of the American Chemical Society, 1945, vol. 67, p. 1182
[3] Patent: US2397422, 1945,
[4] Journal of Organic Chemistry, 1960, vol. 25, p. 1000 - 1006
[5] Patent: JP5664635, 2015, B2

N-OCTYLPHOSPHONIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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N-OCTYLPHOSPHONIC ACID Suppliers

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View Lastest Price from N-OCTYLPHOSPHONIC ACID manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
n-Octylphosphonic acid 4724-48-5
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-04-07
HebeiShuoshengImportandExportco.,Ltd
Product
N-OCTYLPHOSPHONIC ACID 4724-48-5
Price
US $6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000KG/Month
Release date
2024-08-09
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
1-Octyl phosphonic acid 4724-48-5
Price
US $75.00-20.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-30

4724-48-5, N-OCTYLPHOSPHONIC ACIDRelated Search:

N-DODECYLPHOSPHONIC ACID Neodecanoic acid 2-ethylhexyl octanoate TRICAPRIN Decanoyl/octanoyl-glycerides (N,N-Dimethylaminopropyl)trimethoxysilane N-OCTYLTRIBUTYLPHOSPHONIUM BROMIDE N-OCTYLTRIMETHYLAMMONIUM BROMIDE 1-(vinyloxy)octane 1-DECYLPHOSPHONIC ACID Diethyl 1-octanephosphonate~1-Octylphosphonic acid diethyl ester,1-octylphosphonic acid diethyl ester DIETHYL 1-DECYLPHOSPHONATE Tetraethyl decamethylenediphosphonate, 98% N-OCTYLPHOSPHONIC ACID DIETHYL(1-DODECYL)PHOSPHONATE N-TETRADECYLPHOSPHONIC ACID Octadecylphosphonic acid DIETHYL 1-TETRADECANEPHOSPHONATE

  • octyl-Phosphonicacid
  • 1-Octanephosphonic acid
  • 1-Octylphosphonicacid,98%
  • n-Octylphosphonicacid,min.97%
  • Phosphonic acid, octyl-
  • Octylphosphonsure
  • Octanephosphonic acid
  • n-Octylphosphonic acid, min. 97%
  • P-octyl-Phosphonic acid
  • <i>n</i>-Octylphosphonic Acid
  • N-OCTYLPHOSPHONIC ACID
  • octyl-phosphonicaci
  • n-Octylphosphonic acid, min. 97% OPA
  • Phosphonic acid,P-octyl-
  • n-Octylphosphonic acid, 98.5%
  • 1-OCTYLPHOSPHONIC ACID
  • 1-Octylphosphonic acid ASI100
  • n-Octylphosphonic Acid &gt
  • 1-octyl phosphate
  • 1-0ctylphosphonic acid
  • Octylphosphonic Acid (NOPA)
  • 4724-48-5
  • CH3CH27POOH2
  • organic phosphonic acid