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INDIRUBIN-3'-MONOXIME-5-SULPHONIC ACID

Product Name
INDIRUBIN-3'-MONOXIME-5-SULPHONIC ACID
CAS No.
331467-05-1
Chemical Name
INDIRUBIN-3'-MONOXIME-5-SULPHONIC ACID
Synonyms
Indirubin-3'-monoxime-5-sulphonic acid;Indirubin-3'-monoxime-5-sulphonic acid;Indirubin3'monoxime5sulphonic acid,Indirubin 3' monoxime 5 sulphonic acid;1H-Indole-5-sulfonic acid, 3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-2,3-dihydro-2-oxo-
CBNumber
CB8220464
Molecular Formula
C16H11N3O5S
Formula Weight
357.34
MOL File
Mol file
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INDIRUBIN-3'-MONOXIME-5-SULPHONIC ACID Property

storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
solid
color 
dark red
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Hazard and Precautionary Statements (GHS)

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INDIRUBIN-3'-MONOXIME-5-SULPHONIC ACID Chemical Properties,Usage,Production

Uses

Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of CDK1, CDK5, and GSK-3β with IC50s of 5 nM, 7 nM, and 80 nM, respectively[1].

Biological Activity

Cell permeable: no', 'Primary Target
CDK1', 'Product competes with ATP.', 'Reversible: yes', 'Target IC50: 5 nM, 7 nM, 80 nM, against Cdk1, Cdk5, and glycogen synthase kinase-3β (GSK-3β), respectively

IC 50

CDK1: 5 nM (IC50); CDK5: 7 nM (IC50); GSK-3β: 80 nM (IC50)

References

[1] Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors. J Biol Chem. 2001 Jan 5;276(1):251-60. DOI:10.1074/jbc.M002466200

INDIRUBIN-3'-MONOXIME-5-SULPHONIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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INDIRUBIN-3'-MONOXIME-5-SULPHONIC ACID Suppliers

China 10 United Kingdom 1 United States 6 Global 17
Beijing Jin Ming Biotechnology Co., Ltd.
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psaitong@jm-bio.com
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China
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Fan De(Beijing) Biotechnology Co., Ltd.
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15911056312
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liming@bio-fount.com
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TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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Beijing Jin Ming Biotechnology Co., Ltd.
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010-60605840 15801484223;
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psaitong@jm-bio.com
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TargetMol Chemicals Inc.
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marketing@tsbiochem.com
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Merck KGaA
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Yeasen Biotechnology (Shanghai) Co Ltd
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Adooq Bioscience LLC
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Santa Cruz Biotechnology Inc
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021-60936350
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TargetMol Chemicals Inc.
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+17819995354
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marketing@targetmol.com
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United States
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331467-05-1, INDIRUBIN-3'-MONOXIME-5-SULPHONIC ACIDRelated Search:

INDIRUBIN-3'-MONOXIME Indirubin

  • 1H-Indole-5-sulfonic acid, 3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-2,3-dihydro-2-oxo-
  • Indirubin3'monoxime5sulphonic acid,Indirubin 3' monoxime 5 sulphonic acid
  • Indirubin-3'-monoxime-5-sulphonic acid
  • Indirubin-3'-monoxime-5-sulphonic acid
  • 331467-05-1