1-(Ethoxycarbonyl)-β-carboline

1-(Ethoxycarbonyl)-β-carboline Property

Melting point:

145-146 °C

Boiling point:

470.9±25.0 °C(Predicted)

Density 

1.308±0.06 g/cm3(Predicted)

form 

Solid

pka

14.21±0.40(Predicted)

color 

Light yellow to orange

InChI

InChI=1S/C14H12N2O2/c1-2-18-14(17)13-12-10(7-8-15-13)9-5-3-4-6-11(9)16-12/h3-8,16H,2H2,1H3

InChIKey

CFXOOHNXLDSCHT-UHFFFAOYSA-N

SMILES

N1C2=C(C=CC=C2)C2C=CN=C(C(OCC)=O)C1=2

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

1-(Ethoxycarbonyl)-β-carboline Chemical Properties,Usage,Production

Uses

Kumujian A (1-Ethoxycarbonyl-β-carboline), an anti-inflammatory agent, inhibits both superoxide anion generation (IC50 = 4.87 μg/mL) and elastase release (IC50 = 6.29 μg/mL)[1].

References

[1] Fang HW, et al. Total synthesis of cordatanine, structural reassignment of drymaritin, and anti-inflammatory activity of synthetic precursors. Bioorg Med Chem Lett. 2015 Sep 15;25(18):3822-4. DOI:10.1016/j.bmcl.2015.07.074