6-(Benzyloxy)-5-methoxy-1H-indole
- Product Name
- 6-(Benzyloxy)-5-methoxy-1H-indole
- CAS No.
- 2426-59-7
- Chemical Name
- 6-(Benzyloxy)-5-methoxy-1H-indole
- Synonyms
- NSC 92528;6-(Benzyloxy)-5-methoxy-1H-indole;5-Methoxy-6-(phenylMethoxy)-1H-indole;1H-Indole,5-methoxy-6-(phenylmethoxy)-
- CBNumber
- CB82277271
- Molecular Formula
- C16H15NO2
- Formula Weight
- 253.3
- MOL File
- 2426-59-7.mol
6-(Benzyloxy)-5-methoxy-1H-indole Property
- Melting point:
- 147-148°C
- Boiling point:
- 430.9±30.0 °C(Predicted)
- Density
- 1.202±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Acetonitrile (Slightly), Chloroform (Slightly), Dichloromethane (Slightly)
- form
- Solid
- pka
- 16.87±0.30(Predicted)
- color
- Off-White to Light Purple
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B285995
- Product name
- 6-Benzyloxy-5-methoxyindole
- Packaging
- 250mg
- Price
- $315
- Updated
- 2021/12/16
- Product number
- FB18473
- Product name
- 6-Benzyloxy-5-methoxyindole
- Packaging
- 50mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- 5805AQ
- Product name
- 5-methoxy-6-phenylmethoxy-1H-indole
- Packaging
- 100mg
- Price
- $158
- Updated
- 2021/12/16
- Product number
- FB18473
- Product name
- 6-Benzyloxy-5-methoxyindole
- Packaging
- 100mg
- Price
- $227
- Updated
- 2021/12/16
- Product number
- FB18473
- Product name
- 6-Benzyloxy-5-methoxyindole
- Packaging
- 250mg
- Price
- $412.5
- Updated
- 2021/12/16
6-(Benzyloxy)-5-methoxy-1H-indole Chemical Properties,Usage,Production
Chemical Properties
Off-White to Light Purple Solid
Synthesis
75-52-5
2426-84-8
2426-59-7
To a solution of 4-(benzyloxy)-5-methoxy-2-nitrobenzaldehyde (8.60 g, 30 mmol) in acetic acid (80 mL) was added nitromethane (10 mL) and ammonium acetate (3.66 g, 60 mmol, 2 eq.) sequentially. The reaction mixture was stirred at 100 °C for 5 hours. Upon completion of the reaction, the reaction solution was concentrated under reduced pressure and the resulting residue was dissolved in a solvent mixture of toluene (80 mL) and acetic acid (10 mL). To this solution was added iron powder (3.3 g, 60 mmol, 2 eq.) and silica gel (10 g), and the reaction mixture was heated to reflux for 1 hour. The reaction solution was cooled to room temperature and filtered and the filtrate was concentrated under reduced pressure. The concentrated residue was partitioned between water and ethyl acetate, the organic layer was separated, dried over anhydrous sodium sulfate, filtered and concentrated. Finally, the residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate = 3/1) to afford the target product 6-(benzyloxy)-5-methoxy-1H-indole (3.0 g, 11.8 mmol, 39.3% yield) as a yellow solid.
References
[1] Patent: US2016/9706, 2016, A1. Location in patent: Paragraph 0271
6-(Benzyloxy)-5-methoxy-1H-indole Preparation Products And Raw materials
Raw materials
Preparation Products
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