5-Bromo-1,3-phenylenediamine
- Product Name
- 5-Bromo-1,3-phenylenediamine
- CAS No.
- 33786-90-2
- Chemical Name
- 5-Bromo-1,3-phenylenediamine
- Synonyms
- 5-Bromo-3-amino-aniline;3,5-Diamino-bromobenzene;5-Bromo-1,3-benzenediamine;1-Bromo-3,5-Diaminobenzene;5-Bromobenzene-1,3-diamine;5-bromo-m-phenylenediamine;1,3-Benzenediamine, 5-bromo-;5-Bromo-1,3-phenylenediamine;1-Bromo-3,5-diaminobenzene, 5-Bromophenylene-1,3-diamine
- CBNumber
- CB82331711
- Molecular Formula
- C6H7BrN2
- Formula Weight
- 187.04
- MOL File
- 33786-90-2.mol
5-Bromo-1,3-phenylenediamine Property
- Melting point:
- 92 °C
- Boiling point:
- 336.1±22.0 °C(Predicted)
- Density
- 1.697±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- solid
- pka
- 3.81±0.10(Predicted)
- color
- Brown
Safety
- HS Code
- 2921511990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B681933
- Product name
- 5-Bromobenzene-1,3-diamine
- Packaging
- 2mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- B681933
- Product name
- 5-Bromobenzene-1,3-diamine
- Packaging
- 10mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- OR46062
- Product name
- 5-Bromobenzene-1,3-diamine
- Packaging
- 250mg
- Price
- $67
- Updated
- 2021/12/16
- Product number
- FB151782
- Product name
- 5-Bromo-benzene-1,3-diamine
- Packaging
- 100mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- 3630-9-X8
- Product name
- 5-Bromobenzene-1,3-diamine
- Packaging
- 250mg
- Price
- $96
- Updated
- 2021/12/16
5-Bromo-1,3-phenylenediamine Chemical Properties,Usage,Production
Synthesis
18242-39-2
33786-90-2
General procedure for the synthesis of 5-bromo-1,3-benzenediamine from 3,5-dinitrobromobenzene: To a methanol:water (V/V: 50 mL/50 mL) solution of 1-bromo-3,5-dinitrobenzene (10 g, 40 mmol) was added ammonium chloride (17.33 g, 323.9 mmol) and iron powder (11.31 g, 202.5 mmol). The reaction mixture was stirred and refluxed at 95 °C overnight. Upon completion of the reaction, it was filtered through a diatomaceous earth pad to remove the iron powder and the filtrate was concentrated by rotary evaporation to remove methanol. The remaining aqueous phase was extracted with dichloromethane (3 x 50 mL), the organic layers were combined, washed sequentially with water and saturated saline, and dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure to obtain the crude product. The crude product was purified by silica gel column chromatography using appropriate eluents to afford 5-bromo-1,3-benzenediamine (7.01 g, 92% yield) as a yellow solid. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 6.25 (d, 2H, J=2.0 Hz), 5.90 (t, 1H, J=2.0 Hz), 3.60 (s, 4H).
References
[1] European Journal of Medicinal Chemistry, 2017, vol. 126, p. 1107 - 1117
[2] Patent: WO2011/75515, 2011, A1. Location in patent: Page/Page column 259-260
[3] Mendeleev Communications, 2015, vol. 25, # 6, p. 443 - 445
[4] Patent: WO2018/18091, 2018, A1. Location in patent: Paragraph 00125-00126
5-Bromo-1,3-phenylenediamine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Bromo-1,3-phenylenediamine manufacturers
- Product
- 5-Bromo-1,3-phenylenediamine 33786-90-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-08-15
- Product
- 5-Bromo-1,3-phenylenediamine 33786-90-2
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg -1000kg
- Release date
- 2020-01-02