Diazoacetylbenzene
- Product Name
- Diazoacetylbenzene
- CAS No.
- 3282-32-4
- Chemical Name
- Diazoacetylbenzene
- Synonyms
- Nsc25280;Diazoacetylbenzene;2-Diazoacetophenone;α-Diazoacetophenone;Benzoyldiazomethane;a-Diazoacetophenone;Acetophenone, 2-diazo-;2-Diazo-1-phenylethanone;.Omega.-diazoacetophenone;.alpha.-Diazoacetophenone
- CBNumber
- CB82352178
- Molecular Formula
- C8H6N2O
- Formula Weight
- 146.15
- MOL File
- 3282-32-4.mol
Diazoacetylbenzene Property
- Melting point:
- 49 °C
- Boiling point:
- 265.75°C (rough estimate)
- Density
- 1.2312 (rough estimate)
- refractive index
- 1.4900 (estimate)
- solubility
- sol ether, THF; slightly sol pentane.
- form
- rods
- color
- pale yellow
N-Bromosuccinimide Price
- Product number
- CHM0078512
- Product name
- 2-DIAZOACETOPHENONE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $909.56
- Updated
- 2021/12/16
- Product number
- SC-86503
- Product name
- 2-DIAZO-1-PHENYLETHANONE
- Purity
- 95
- Packaging
- 5g
- Price
- $2250
- Updated
- 2021/12/16
Diazoacetylbenzene Chemical Properties,Usage,Production
Uses
α-Diazoacetophenone is used as a precursor to carbenes and carbenoids; reagent for preparation of sulfonium, oxonium, and pyridinium ylides; 1,3 dipole for heterocycle synthesis; reagent for Lewis acid or transition metal-mediated insertion reactions; reagent for cyclopropanation of alkenes and for aromatic annulation.
Preparation
Preparative Methods of α-Diazoacetophenone: an improved method of synthesis of diazo ketones has been recently published, via acylation of the lithium enolate of the ketone with 2,2,2-Trifluoroethyl Trifluoroacetate and subsequent reaction with Methanesulfonyl Azide. [1] Alternatively, acylation of diazomethane with aroyl chlorides in the presence of triethylamine provides a general method for the synthesis of aromatic diazo ketones.[2]
storage
diazoacetophenone is a skin irritant; therefore direct contact should be avoided. Diazoacetophenone has shown microbial mutagenicity.
References
1. Danheiser, R. L.; Miller, R. F.; Brisbois, R. G.; Park, S. Z. JOC 1990, 55, 1959.
2. Bridson, J. N.; Hooz, J. OS 1973, 53, 35.
Diazoacetylbenzene Preparation Products And Raw materials
Raw materials
Preparation Products
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