ChemicalBook > CAS DataBase List > ZANAPEZIL

ZANAPEZIL

Product Name
ZANAPEZIL
CAS No.
142852-50-4
Chemical Name
ZANAPEZIL
Synonyms
ZANAPEZIL;TAK-147 free base;Zanapezil free base;1-Propanone, 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)-
CBNumber
CB82446501
Molecular Formula
C25H32N2O
Formula Weight
376.53
MOL File
142852-50-4.mol
More
Less

ZANAPEZIL Property

form 
Solid
color 
White to light yellow
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

TRC
Product number
Z148050
Product name
Zanapezil
Packaging
25mg
Price
$2970
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0012810
Product name
ZANAPEZIL
Purity
95.00%
Packaging
5MG
Price
$500.48
Updated
2021/12/16
More
Less

ZANAPEZIL Chemical Properties,Usage,Production

Uses

Zanapezil is a acetylcholinesterase inhibitor that is a potential drug for treating Alzheimer disease.

Definition

ChEBI: Zanapezil is a member of piperidines.

in vivo

Oral administration of Zanapezil (TAK-147; 3 mg/kg) free base significantly accelerated the turnover rates of dopamine, noradrenaline and serotonin in the rat brain. Oral administration of Zanapezil free base at doses ranging from 1 to 10 mg/kg induces a statistically significant and dose-dependent decrease in AChE activity in the cerebral cortex in ex vivo experiments[1].
Zanapezil (TAK-147; 5 and 10 mg/kg) free base significantly increases ACh level in the ventral hippocampus (VH) for 120 min[2].

Animal Model:Male Wistar rats 7 weeks in age (230-240 g)[2]
Dosage:5 and 10 mg/kg
Administration:Oral administration
Result:Increased acetylcholine (ACh) level in the VH for 120 min.

IC 50

AChE

ZANAPEZIL Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

ZANAPEZIL Suppliers

China 4 India 1 United States 1 Global 6
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Shanghai Tachizaki Biomedical Research Center
Tel
18014399201
Email
sales@chemlab-tachizaki.com
Country
China
ProdList
2742
Advantage
58
Biosynth Biological Technology (Suzhou) Co Ltd
Tel
51288865780
Email
sales@biosynth.com
Country
China
ProdList
6051
Advantage
58

142852-50-4, ZANAPEZILRelated Search:

2,3,4,5-Tetrahydro-1H-benzo[b]azepine ZANAPEZIL

  • ZANAPEZIL
  • 1-Propanone, 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)-
  • TAK-147 free base
  • Zanapezil free base
  • 142852-50-4