7-BROMO-2,3-DIHYDRO-1-BENZOFURAN
- Product Name
- 7-BROMO-2,3-DIHYDRO-1-BENZOFURAN
- CAS No.
- 206347-30-0
- Chemical Name
- 7-BROMO-2,3-DIHYDRO-1-BENZOFURAN
- Synonyms
- 7-Bromo-2,3-dihydrobenzofuran;7-Bromo-2,3-dihydrobenzofurane;Benzofuran, 7-bromo-2,3-dihydro-;7-Bromo-2,3-dihydrobenzo[b]furan;7-BROMO-2,3-DIHYDRO-1-BENZOFURAN
- CBNumber
- CB82449683
- Molecular Formula
- C8H7BrO
- Formula Weight
- 199.04
- MOL File
- 206347-30-0.mol
7-BROMO-2,3-DIHYDRO-1-BENZOFURAN Property
- Boiling point:
- 254.4±29.0 °C(Predicted)
- Density
- 1.582±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- Appearance
- White to light yellow Solid
Safety
- HS Code
- 2932990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B691338
- Product name
- 7-Bromo-2,3-dihydrobenzofuran
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B691338
- Product name
- 7-Bromo-2,3-dihydrobenzofuran
- Packaging
- 500mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- B691338
- Product name
- 7-Bromo-2,3-dihydrobenzofuran
- Packaging
- 1g
- Price
- $195
- Updated
- 2021/12/16
- Product number
- 129958
- Product name
- 7-Bromo-2,3-dihydro-benzofuran
- Purity
- 95%+
- Packaging
- 1g
- Price
- $145
- Updated
- 2021/12/16
- Product number
- W4337
- Product name
- 7-Bromo-2,3-dihydrobenzofuran
- Packaging
- 1g
- Price
- $169
- Updated
- 2021/12/16
7-BROMO-2,3-DIHYDRO-1-BENZOFURAN Chemical Properties,Usage,Production
Synthesis
206347-32-2
206347-30-0
Synthesis of 7-bromo-2,3-dihydrobenzofuran: In a dry reaction flask, 1,3-dibromo-2-(2-bromoethoxy)benzene (11.5 g, 32.0 mmol) was dissolved in a mixed solvent of 115 mL of anhydrous THF and 28 mL of hexane. The reaction system was cooled to -78 °C under nitrogen protection, and 2.5 M n-butyllithium (n-BuLi, 13.0 mL, 32.5 mmol) solution was slowly added dropwise for a controlled time of 30 min. After the dropwise addition was completed, the reaction was kept at -78 °C for 30 min and then the reaction system was slowly warmed up to 0 °C. After completion of the reaction, the mixture was carefully poured into 100 mL of ice water and the aqueous phase was extracted with ether (3 x 50 mL). The organic layers were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to give a light yellow oily crude product. The crude product was purified by silica gel column chromatography with gradient elution of ethyl acetate/hexane to afford colorless needle-like crystals of 7-bromo-2,3-dihydrobenzofuran (5.00 g, 78% yield). The structure of the product was confirmed by 1H NMR (500 MHz, DMSO-d6): δ 7.27 (dd, J=1,8Hz, 1H), 7.20 (dd, J=1,7.5Hz, 1H), 6.75 (t, J=7.8Hz, 1H), 4.59 (t, J=9Hz, 2H), 3.28 (t, J=8.8Hz, 2H).
References
[1] Tetrahedron Letters, 1998, vol. 39, # 15, p. 2219 - 2222
[2] Patent: US2006/30583, 2006, A1. Location in patent: Page/Page column 104
[3] Patent: EP1972628, 2008, A1. Location in patent: Page/Page column 56-57
[4] Patent: US2010/16297, 2010, A1. Location in patent: Page/Page column 34
7-BROMO-2,3-DIHYDRO-1-BENZOFURAN Preparation Products And Raw materials
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