1,1-Dimethylethyl 3-Oxo-4-Morpholinecarboxylate
- Product Name
- 1,1-Dimethylethyl 3-Oxo-4-Morpholinecarboxylate
- CAS No.
- 142929-48-4
- Chemical Name
- 1,1-Dimethylethyl 3-Oxo-4-Morpholinecarboxylate
- Synonyms
- tert-butyl 3-oxomorpholine-4-carboxylate;4-Boc-3-oxomorpholine;4-MORPHOLINECARBOXYLIC ACID, 3-OXO-, 1,1-DIMETH;1,1-Dimethylethyl 3-Oxo-4-Morpholinecarboxylate;4-MORPHOLINECARBOXYLIC ACID, 3-OXO-, 1,1-DIMETHYLETHYL ESTER
- CBNumber
- CB82450168
- Molecular Formula
- C9H15NO4
- Formula Weight
- 201.22
- MOL File
- 142929-48-4.mol
1,1-Dimethylethyl 3-Oxo-4-Morpholinecarboxylate Property
- Boiling point:
- 337.5±35.0 °C(Predicted)
- Density
- 1.168±0.06 g/cm3(Predicted)
- pka
- -2.52±0.20(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B871673
- Product name
- tert-butyl3-oxomorpholine-4-carboxylate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CS-0039097
- Product name
- tert-Butyl3-oxomorpholine-4-carboxylate
- Purity
- 97.03%
- Packaging
- 250mg
- Price
- $56
- Updated
- 2021/12/16
- Product number
- CS-0039097
- Product name
- tert-Butyl3-oxomorpholine-4-carboxylate
- Purity
- 97.03%
- Packaging
- 1g
- Price
- $115
- Updated
- 2021/12/16
- Product number
- CS-0039097
- Product name
- tert-Butyl3-oxomorpholine-4-carboxylate
- Purity
- 97.03%
- Packaging
- 5g
- Price
- $395
- Updated
- 2021/12/16
- Product number
- CHM0382613
- Product name
- 3-OXO-4-MORPHOLINECARBOXYLIC ACID-1,1-DIMETHYLETHYL ESTER
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.94
- Updated
- 2021/12/16
1,1-Dimethylethyl 3-Oxo-4-Morpholinecarboxylate Chemical Properties,Usage,Production
Synthesis
109-11-5
24424-99-5
142929-48-4
Step 1: Synthesis of tert-butyl 3-oxomorpholine-4-carboxylate 3-Morpholinone (35 g, 346.2 mmol) was suspended in anhydrous tetrahydrofuran (350 mL). Di-tert-butyl dicarbonate (105.8 g, 484.7 mmol) and 4-dimethylaminopyridine (4.2 g, 34.6 mmol) were added sequentially. The reaction mixture started to release gas vigorously within 30 minutes. The resulting orange solution was stirred at room temperature for 24 hours. Subsequently, the mixture was cooled in an ice bath and imidazole (23.57 g, 346.2 mmol) was added. After stirring for 30 minutes, the mixture was diluted by adding ethyl acetate (500 mL). The organic phase was separated and washed sequentially with 1% (v/v) hydrochloric acid (500 mL), saturated sodium bicarbonate solution (500 mL) and brine (200 mL). The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated. The crude product was purified by silica gel column chromatography using ethyl acetate as eluent. The eluate was collected and concentrated to give an oil. 40/60 petroleum ether (200 mL) was added slowly and a white solid was precipitated with stirring. The mixture was aged for 30 minutes, cooled briefly in an ice bath, filtered and washed with 40/60 petroleum ether. Vacuum drying gave tert-butyl 3-oxomorpholine-4-carboxylate as a white solid (52.7 g, 76% yield). 1H-NMR (CDCl3) δ: 1.47 (9H, s), 3.68 (2H, m), 3.82 (2H, m), 4.15 (2H, s). MS ES (+) m/z: 145.8 (M+ -tBu).
References
[1] Patent: WO2013/49719, 2013, A1. Location in patent: Paragraph 00197
[2] Patent: WO2017/12576, 2017, A1. Location in patent: Page/Page column 177
[3] Journal of Medicinal Chemistry, 1992, vol. 35, # 16, p. 2928 - 2938
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View Lastest Price from 1,1-Dimethylethyl 3-Oxo-4-Morpholinecarboxylate manufacturers
- Product
- 1,1-dimethylethyl 3-oxo-4-morpholinecarboxylate 142929-48-4
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2020-02-11