2-AMINO-3-BROMO-5-CHLOROPYRAZINE
- Product Name
- 2-AMINO-3-BROMO-5-CHLOROPYRAZINE
- CAS No.
- 76537-18-3
- Chemical Name
- 2-AMINO-3-BROMO-5-CHLOROPYRAZINE
- Synonyms
- Amino-3-bromo-5-chloropyrazine;3-broMo-5-chloropyrazin-2-aMine;2-amine-3-bromo-5-chloropyrazin;3-Bromo-5-chloro-2-aminopyrazine;2-AMINO-3-BROMO-5-CHLOROPYRAZINE;3-Bromo-5-chloropyrazin-2-ylamine;2-Pyrazinamine, 3-bromo-5-chloro-;2-AMINO-3-BROMO-5-CHLOROPYRAZINE ISO 9001：2015 REACH
- CBNumber
- CB82452773
- Molecular Formula
- C4H3BrClN3
- Formula Weight
- 208.44
- MOL File
- 76537-18-3.mol
2-AMINO-3-BROMO-5-CHLOROPYRAZINE Property
- Boiling point:
- 298.4±35.0 °C(Predicted)
- Density
- 1.96
- refractive index
- 1.66
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 0.89±0.10(Predicted)
- Appearance
- Light yellow to brown Solid
- InChI
- InChI=1S/C4H3BrClN3/c5-3-4(7)8-1-2(6)9-3/h1H,(H2,7,8)
- InChIKey
- ACFBUXHJONGLLF-UHFFFAOYSA-N
- SMILES
- C1(N)=NC=C(Cl)N=C1Br
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A594270
- Product name
- 2-Amino-3-bromo-5-chloropyrazine
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- A594270
- Product name
- 2-Amino-3-bromo-5-chloropyrazine
- Packaging
- 1g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- 071152
- Product name
- 3-Bromo-5-chloropyrazin-2-amine
- Purity
- 97%
- Packaging
- 5g
- Price
- $200
- Updated
- 2021/12/16
- Product number
- 071152
- Product name
- 3-Bromo-5-chloropyrazin-2-amine
- Purity
- 97%
- Packaging
- 10g
- Price
- $525
- Updated
- 2021/12/16
- Product number
- 071152
- Product name
- 3-Bromo-5-chloropyrazin-2-amine
- Purity
- 97%
- Packaging
- 1g
- Price
- $65
- Updated
- 2021/12/16
2-AMINO-3-BROMO-5-CHLOROPYRAZINE Chemical Properties,Usage,Production
Synthesis
33332-29-5
76537-18-3
General procedure for the synthesis of 2-amino-3-bromo-5-chloropyrazine from 2-amino-5-chloropyrazine: 2-amino-5-chloropyrazine (3 g, 23 mmol), N-bromosuccinimide (4 g, 23 mmol), and dichloromethane (100 mL) were added to a 250 mL round-bottomed flask under nitrogen protection. The reaction mixture was heated and refluxed for 1 h before being cooled to room temperature and concentrated under reduced pressure. The crude product was purified by fast column chromatography using pentane/ethyl acetate (0 to 50%) as eluent to afford 2-amino-3-bromo-5-chloropyrazine (3 g, 62% yield).1H NMR (DMSO-d6) δ 6.8-6.9 (2H, broad single peak), 8.0 (1H, single peak). Mass spectrum (ES+): m/z 210, 212.
References
[1] Journal of Medicinal Chemistry, 1997, vol. 40, # 6, p. 996 - 1004
[2] Patent: WO2006/58074, 2006, A1. Location in patent: Page/Page column 20
[3] Patent: US5866568, 1999, A
[4] Patent: US5668137, 1997, A
[5] Patent: WO2018/98499, 2018, A1. Location in patent: Page/Page column 283
2-AMINO-3-BROMO-5-CHLOROPYRAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-AMINO-3-BROMO-5-CHLOROPYRAZINE manufacturers
- Product
- 2-Amino-3-bromo-5-chloropyrazine 76537-18-3
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%+
- Supply Ability
- 800 tons
- Release date
- 2020-04-29
- Product
- 2-AMINO-3-BROMO-5-CHLOROPYRAZINE 76537-18-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 150KG
- Release date
- 2019-07-02