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N-CBZ-3-OXOAZETIDINE

Product Name
N-CBZ-3-OXOAZETIDINE
CAS No.
105258-93-3
Chemical Name
N-CBZ-3-OXOAZETIDINE
Synonyms
1-Cbz-3-azetidinone;N-CBZ-3-OXOAZETIDINE;1-Cbz-3-azetidinone - [C1509];Azetidin-3-one, N-CBZ protected;Benzyl 3-oxo-1-azetidinecarboxylate;1-(Benzyloxycarbonyl)azetidin-3-one;3-Oxo-azetidine-1-carboxylic acid benzyl ester;3-oxo-1-azetidinecarboxylic acid (phenylmethyl) ester;1-Azetidinecarboxylic acid, 3-oxo-, phenylMethyl ester;3-Oxo-azetidine-1-carboxylic acid benzyl ester 105258-93-3
CBNumber
CB82453341
Molecular Formula
C11H11NO3
Formula Weight
205.21
MOL File
105258-93-3.mol
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N-CBZ-3-OXOAZETIDINE Property

Melting point:
40-44°
Boiling point:
356.5±42.0 °C(Predicted)
Density 
1.308±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
-2.04±0.20(Predicted)
form 
solid
color 
White
InChI
InChI=1S/C11H11NO3/c13-10-6-12(7-10)11(14)15-8-9-4-2-1-3-5-9/h1-5H,6-8H2
InChIKey
VLMMTGKGDOAYER-UHFFFAOYSA-N
SMILES
N1(C(OCC2=CC=CC=C2)=O)CC(=O)C1
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Safety

HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
B194120
Product name
Benzyl3-Oxoazetidine-1-carboxylate
Packaging
250mg
Price
$55
Updated
2021/12/16
Synthonix
Product number
C1509
Product name
1-Cbz-3-azetidinone
Purity
97.0%
Packaging
5g
Price
$25
Updated
2021/12/16
Apolloscientific
Product number
OR309040
Product name
Azetidin-3-one, N-CBZ protected
Purity
97%
Packaging
5g
Price
$33
Updated
2021/12/16
SynQuest Laboratories
Product number
4H51-1-40
Product name
Azetidin-3-one, N-Cbz protected
Packaging
5G
Price
$39
Updated
2021/12/16
AK Scientific
Product number
X8749
Product name
Benzyl3-oxoazetidine-1-carboxylate
Packaging
5g
Price
$41
Updated
2021/12/16
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N-CBZ-3-OXOAZETIDINE Chemical Properties,Usage,Production

Synthesis

128117-22-6

105258-93-3

General procedure for the synthesis of 1-Benzyloxycarbonyl-3-hydroxyazetidin-3-one from 1-Benzyloxycarbonylazetidin-3-one: Triphenylmethyl-3-hydroxyazetidin-1-carboxylate (3.5 g, 0.0168 mol) was dissolved in dichloromethane (100 mL) at room temperature, followed by the addition of Dess-Martin periodinane (10.7 g, 0.025 mol). The reaction mixture was stirred at room temperature for 5 hours. Upon completion of the reaction, the reaction was quenched with a 1:1 ratio of saturated aqueous sodium bicarbonate and 1 M sodium thiosulfate solution (200 mL). The mixture was extracted with dichloromethane and the organic layer was separated. The organic layer was dried with anhydrous magnesium sulfate and subsequently concentrated under reduced pressure to afford phenylmethyl 3-oxoazetidine-1-carboxylate (3.43 g, 99% yield), the product was a clear, colorless oil, which did not require further purification. The product was confirmed by 1H NMR (400 MHz, CDCl3): δ 7.39-7.31 (m, 5H), 5.17 (s, 2H), 4.77 (s, 4H). Mass spectrometry (EI) analysis was consistent with the molecular weight of C11H11NO3: 205 (M+).

References

[1] Patent: WO2007/44515, 2007, A1. Location in patent: Page/Page column 165
[2] Patent: WO2008/76415, 2008, A1. Location in patent: Page/Page column 329
[3] Patent: WO2008/124085, 2008, A2. Location in patent: Page/Page column 179
[4] Patent: WO2014/32, 2014, A1. Location in patent: Page/Page column 33; 34
[5] Patent: WO2013/8002, 2013, A1. Location in patent: Page/Page column 49

N-CBZ-3-OXOAZETIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-CBZ-3-OXOAZETIDINE Suppliers

China 139 Germany 1 India 4 United Kingdom 3 United States 10 Global 157
BTC pharm India
Tel
+918790379245
Email
banny.janga@btcpharm.com
Country
India
ProdList
1262
Advantage
58
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from N-CBZ-3-OXOAZETIDINE manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
1-Cbz-3-azetidinone 105258-93-3
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-12
Hebei Chuanghai Biotechnology Co,.LTD
Product
Benzyl 3-Oxoazetidine-1-Carboxylate 105258-93-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99.%
Supply Ability
50 ton
Release date
2024-07-30
Henan Fengda Chemical Co., Ltd
Product
Benzyl 3-oxo-1-azetidinecarboxylate 105258-93-3
Price
US $200.00-1.00/KG
Min. Order
1KG
Purity
99%, 99.5% Sublimated
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-30

105258-93-3, N-CBZ-3-OXOAZETIDINERelated Search:

N-CBZ-3-OXOAZETIDINE

  • N-CBZ-3-OXOAZETIDINE
  • 1-Cbz-3-azetidinone
  • 3-Oxo-azetidine-1-carboxylic acid benzyl ester
  • 1-Azetidinecarboxylic acid, 3-oxo-, phenylMethyl ester
  • Azetidin-3-one, N-CBZ protected
  • Benzyl 3-oxoazetidine-1-carboxylate, 1-[(Benzyloxy)carbonyl]-3-oxoazetidine
  • 1-(Benzyloxycarbonyl)azetidin-3-one
  • 3-oxo-1-azetidinecarboxylic acid (phenylmethyl) ester
  • 3-Oxo-azetidine-1-carboxylic acid benzyl ester 105258-93-3
  • Benzyl 3-oxo-1-azetidinecarboxylate
  • 1-Cbz-3-azetidinone - [C1509]
  • 105258-93-3