ChemicalBook > CAS DataBase List > Y 134

Y 134

Product Name
Y 134
CAS No.
849662-80-2
Chemical Name
Y 134
Synonyms
Y 134;Y-134,Y134;[6-HYDROXY-2-(4-HYDROXYPHENYL)BENZO[B]THIEN-3-YL]-[4-[4-(1-METHYLETHYL)-1-PIPERAZINYL]PHENYL]METHANONE;Methanone, [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[4-(1-methylethyl)-1-piperazinyl]phenyl]-
CBNumber
CB82453417
Molecular Formula
C28H28N2O3S
Formula Weight
472.6
MOL File
849662-80-2.mol
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Y 134 Property

storage temp. 
Desiccate at RT
solubility 
Soluble to 100 mM in DMSO and to 100 mM in ethanol
form 
Powder
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
2676
Product name
Y134
Purity
≥98%(HPLC)
Packaging
10
Price
$191
Updated
2021/12/16
Tocris
Product number
2676
Product name
Y134
Purity
≥98%(HPLC)
Packaging
50
Price
$751
Updated
2021/12/16
TRC
Product number
Y120005
Product name
Y134
Packaging
10mg
Price
$160
Updated
2021/12/16
Usbiological
Product number
257137
Product name
Y 134
Packaging
10mg
Price
$466
Updated
2021/12/16
TRC
Product number
Y120005
Product name
Y134
Packaging
50mg
Price
$710
Updated
2021/12/16
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Y 134 Chemical Properties,Usage,Production

Uses

Y 134 is a SERM displaying selectivity for ERα over ERβ.

Definition

ChEBI: [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(4-propan-2-yl-1-piperazinyl)phenyl]methanone is an aromatic ketone.

Biological Activity

Selective estrogen receptor modulator (SERM) that displays selectivity for ER α over ER β (K i values are 0.09 and 11.31 nM respectively) and no cross-reactivity with mineralocorticoid, glucocorticoid, androgen and progesterone receptors. Acts as an agonist in the bone and antagonist in reproductive tissue. Suppresses estrogen-stimulated proliferation of ER-positive human breast cancer MCF-7 and T47D cells.

in vivo

Y134 (1-3 mg/kg/day; p.o. for 3 days) abolishes the E2-induced mammary gland terminal end bud (TEB) outgrowth in ovariectomized rats. Y134 inhibits uterine cell proliferation induced by E2 in a dose-dependent manner[1].

Animal Model:Four-week old female Sprague-Dawley rats were received ovariectomy[1]
Dosage:1, 3 mg/kg
Administration:P.o. daily for 3 days
Result:Abolished the effect exerted by E2 in a dose-dependent manner.

IC 50

ERα: 0.09 nM (Ki); ERβ: 11.31 nM (Ki)

storage

Desiccate at RT

Y 134 Preparation Products And Raw materials

Raw materials

Preparation Products

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Y 134 Suppliers

China 25 United Kingdom 1 United States 6 Global 32
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
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China
ProdList
15838
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EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
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60
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
86249
Advantage
60
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9550
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32467
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58
ShangHai ChuanQian Chemcial Technique Centre
Tel
15869524721
Email
3525679403@qq.com
Country
China
ProdList
4411
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58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
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58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24960
Advantage
58

849662-80-2, Y 134Related Search:

Y 134

  • [6-HYDROXY-2-(4-HYDROXYPHENYL)BENZO[B]THIEN-3-YL]-[4-[4-(1-METHYLETHYL)-1-PIPERAZINYL]PHENYL]METHANONE
  • Y 134
  • Methanone, [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[4-(1-methylethyl)-1-piperazinyl]phenyl]-
  • Y-134,Y134
  • 849662-80-2