5-BROMO-1H-IMIDAZO[4,5-B]PYRAZINE

5-BROMO-1H-IMIDAZO[4,5-B]PYRAZINE Property

Melting point:

>188°C

Boiling point:

249.2±50.0 °C(Predicted)

Density 

2.28±0.1 g/cm3(Predicted)

storage temp. 

-20°C, Inert atmosphere

solubility 

Chloroform (Slightly, Sonicated), DMSO (Slightly)

form 

Solid

pka

3.98±0.20(Predicted)

color 

Light Beige to Beige

Safety

HS Code 

2933998090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

5-BROMO-1H-IMIDAZO[4,5-B]PYRAZINE Chemical Properties,Usage,Production

Synthesis

(b) 5-Bromo-2,3-diaminopyrazine (7.8 g, 41.3 mmol, 1 equiv) was added to a 250 mL reaction vial. 80 mL of N,N-dimethylformamide (DMF) was added with continuous stirring to dissolve 5-bromo-2,3-diaminopyrazine. Subsequently, triethyl orthoformate (7.34 g, 49.5 mmol, 1.2 eq.) and 20 mL of formic acid were added dropwise (at a rate of about 1 drop/second). The reaction mixture was heated to reflux and maintained under nitrogen protection for 24 hours (the reaction was monitored by thin layer chromatography (TLC) until the feedstock was essentially consumed). Upon completion of the reaction, the solvent was removed by distillation under reduced pressure and the residue was dissolved in methanol. Finally, purification by silica gel column chromatography afforded 5 g of 5-bromo-1H-imidazo[4,5-b]pyrazine.

References

[1] Patent: CN108395436, 2018, A. Location in patent: Paragraph 0010; 0013